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Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken 'on-demand'.

Author: MolteniP, PaceF, PallottaS, PorroG B, ToniniM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

On-demand therapy with PPI appears to be effective in the long-term management of patients with NERD or mild and uninvestigated forms of GERD, but not in patients with (severe) erosive oesophagitis.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Proton pump inhibitors (PPI) therapy 'on-demand' is often used as an alternative to continuous maintenance therapy in gastro-oesophageal reflux disease (GERD). AIM: We conducted a systematic review with the specific objectives to ascertain whether on-demand PPI therapy was effective in ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2007.03381.x

データ提供：米国国立医学図書館（NLM）

On-Demand Proton Pump Inhibitors for GERD: A Systematic Review

Gastroesophageal reflux disease (GERD), a common condition characterized by acid reflux, is a frequent inhabitant of the vast desert of digestive disorders. This research investigates the effectiveness of on-demand proton pump inhibitor (PPI) therapy for managing GERD symptoms. The study conducted a systematic review of randomized-controlled clinical trials comparing on-demand PPI therapy with placebo or continuous PPI therapy. The findings suggest that on-demand PPI therapy is effective in managing patients with non-erosive reflux disease or mild GERD symptoms but is not as effective in patients with erosive esophagitis.

On-Demand PPI Therapy: A Viable Option for Some GERD Patients

The study provides evidence that on-demand PPI therapy can be an effective option for managing GERD symptoms in patients with non-erosive reflux disease or mild GERD. However, for patients with erosive esophagitis, continuous PPI therapy may be a more appropriate choice.

GERD: A Spectrum of Symptoms and Treatments

GERD is a spectrum of conditions, with a range of symptoms and treatment options. This research highlights the importance of tailoring treatment approaches based on the individual patient's specific condition and symptoms.

Dr.Camel's Conclusion

The desert of GERD research is constantly evolving. This systematic review provides valuable insights into the effectiveness of on-demand PPI therapy for managing GERD symptoms. The findings suggest that on-demand therapy can be a viable option for some patients but may not be suitable for everyone.

Date :
  1. Date Completed 2007-12-12
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

17593065

DOI: Digital Object Identifier

10.1111/j.1365-2036.2007.03381.x

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Languages

English

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