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Analysis of the effect of memantine in reducing the worsening of clinical symptoms in patients with moderate to severe Alzheimer's disease.

Author: AndersenHenning Friis, WilkinsonDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Memantine reduced clinical worsening in patients with moderate to severe Alzheimer's disease. 28% of patients on placebo showed any clinical worsening compared to 18% of patients on memantine. 21% of patients on placebo had marked clinical worsening compared to 11% of patients on memantine.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and delaying disease worsening is a relevant treatment outcome. METHODS: Data from 6 randomized, double-blind, placebo-controlled, 6-month studies were pooled and a subgroup of patients (867 on placebo, 959 on memantin...See full text at original site
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引用元：
https://doi.org/10.1159/000105162

データ提供：米国国立医学図書館（NLM）

Memantine: A Beacon of Hope for Alzheimer's Disease

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is like a desert where memories fade and cognitive abilities decline. This study investigates the effects of memantine, a medication used to treat AD, on the worsening of clinical symptoms. It's like exploring the potential of a new water source to sustain life in the desert.

Memantine's Protective Effects

The study found that memantine was associated with a reduction in the worsening of clinical symptoms in patients with moderate to severe AD. It's like finding a way to preserve the oasis, slowing down the rate of erosion and extending its life.

A New Hope for Patients

The findings suggest that memantine may help slow down the progression of AD and improve the quality of life for patients. It’s like discovering a way to find a new source of water in the desert, providing sustenance and hope for a brighter future.

Dr.Camel's Conclusion

This study offers a glimmer of hope for those battling Alzheimer's disease. Memantine, a medication used to treat AD, demonstrates a potential to slow the progression of the disease and improve the quality of life for patients. This research underscores the importance of continuous research and development of new therapies to combat this devastating disease.
Date :
  1. Date Completed 2007-10-31
  2. Date Revised 2023-08-15
Further Info :

Pubmed ID

17622761

DOI: Digital Object Identifier

10.1159/000105162

Related Literature

Article Analysis
・Effective treatment of alzheimer's disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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