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WITHDRAWN: Androgens versus placebo or no treatment for idiopathic oligo/asthenospermia.

Author: HughesE, LilfordR, VailA, VandekerckhoveP

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines the use of androgens to treat male infertility characterized by low sperm count, reduced sperm motility, and abnormal sperm shape (oligo-astheno-teratospermia). While androgens are involved in sperm production and maturation, testosterone can suppress sperm production. The review discusses two approaches: "stimulatory" androgens, which aim to directly increase sperm production or affect sperm transport, and "rebound" androgens, which suppress sperm production and then allow for a rebound effect after treatment ends. The review analyzes the evidence for both approaches.
Paper Details　
Original Abstract of the Article :
Oligo-astheno-teratospermia (sperm of low concentration, reduced motility and increased abnormal morphology) of unknown cause is common and the need for treatment is felt by patients and doctors alike. As a result, a variety of empirical, non-specific treatments have been used in an attempt to impro...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD000150

データ提供：米国国立医学図書館（NLM）

Androgens and Male Infertility: A Complex Relationship

[Male infertility] is a multifaceted issue, and [androgens] have been investigated as a potential treatment for [idiopathic oligo/asthenospermia]. This [review] examines the available evidence on the effects of [androgens] in this context, considering the different proposed mechanisms of action, [stimulatory and rebound therapy]. The authors explore the potential benefits and drawbacks of [androgen therapy] for [male infertility], acknowledging the [negative feedback] on the [pituitary-gonadal axis] and its potential to [suppress FSH and LH secretion], ultimately impacting [spermatogenesis]. The review concludes that more research is needed to clarify the role of [androgens] in [treating male infertility].

Androgens: A Double-Edged Sword in Male Infertility

This [review] sheds light on the complex relationship between [androgens] and [male infertility]. While [androgens] have been proposed as a treatment option, the research highlights the potential [negative effects] on [hormonal regulation] and [spermatogenesis]. This underscores the need for [cautious use] and [further investigation] to better understand the [potential risks and benefits] of [androgen therapy] for [male infertility].

Seeking Solutions for Male Infertility: A Holistic Approach

The findings of this [review] emphasize the importance of [holistic approach] to [male infertility]. While [androgens] may play a role in certain cases, it is crucial to consider the [individual factors] and [underlying causes] of [infertility]. Consultation with a medical professional is essential to develop a personalized treatment plan that addresses the unique needs of each individual.

Dr. Camel's Conclusion

Imagine a desert traveler with a weary camel, struggling to find an oasis of fertility. Androgens, like a mirage in the desert, can appear promising but often lead to more confusion. This review underscores the need for a more thorough understanding of the complexities of male infertility and the potential risks and benefits of androgen therapy before embarking on this journey.

Date :
  1. Date Completed 2007-10-18
  2. Date Revised 2020-05-11
Further Info :

Pubmed ID

17636603

DOI: Digital Object Identifier

10.1002/14651858.CD000150

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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