Paper Details

  1. Home
  2. Paper Details

WITHDRAWN: Gonadotrophin-releasing hormone analogues for pain associated with endometriosis.

Author: DearyA J, FarquharC, Goldbeck-WoodS, PrenticeA, SmithS K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Endometriosis, a common condition causing pain, occurs when uterine-like tissue grows outside the uterus. Because endometriosis is less common in postmenopausal women with low estrogen levels, GnRH analogues (GnRHAs) are used to create a temporary, artificial menopause, reducing estrogen levels and potentially alleviating symptoms. GnRHAs work by constantly suppressing the pituitary gland, which normally responds to natural pulses of GnRH, leading to a decrease in female hormones.
Paper Details　
Original Abstract of the Article :
Endometriosis is a common gynaecological condition that frequently presents with the symptom of pain. The precise pathogenesis (mode of development) of endometriosis is unclear but it is evident that endometriosis arises by the dissemination of endometrium to ectopic sites and the subsequent establi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1002/14651858.CD000346.pub2

データ提供：米国国立医学図書館（NLM）

Gonadotrophin-Releasing Hormone Analogues for Endometriosis Pain: A Critical Assessment

This study examines the use of gonadotrophin-releasing hormone analogues (GnRHAs) for the management of pain associated with endometriosis, a common gynecological condition characterized by the presence of endometrial tissue outside the uterus. The authors discuss the potential benefits and limitations of GnRHAs in treating endometriosis pain, highlighting the mechanism of action of these drugs in inducing a pseudo-menopausal state by downregulating the pituitary gland. The study acknowledges the limited evidence supporting the use of GnRHAs for endometriosis pain and recommends further research to evaluate their efficacy and safety in this context.

GnRHAs for Endometriosis Pain: A Balanced Perspective

This study provides a critical assessment of the use of GnRHAs for endometriosis pain, highlighting the potential benefits and limitations of this approach. The authors emphasize the importance of weighing the potential benefits of pain relief against the potential risks and side effects associated with GnRHAs. The study also underscores the need for further research to establish the efficacy and safety of GnRHAs in treating endometriosis pain.

Endometriosis Pain: A Multifaceted Challenge

This study highlights the complexities of managing endometriosis pain, emphasizing the need for a multidisciplinary approach that considers the individual patient's symptoms, preferences, and medical history. The authors recommend a personalized treatment plan that may involve a combination of therapies, including GnRHAs, pain medications, and lifestyle modifications, to optimize pain management and improve quality of life.

Dr.Camel's Conclusion

This study presents a thoughtful analysis of the use of GnRHAs for endometriosis pain. It's a reminder that the desert of medical knowledge is vast and complex, requiring careful navigation and a balanced approach to treatment decisions. While GnRHAs may offer potential benefits for certain patients, further research is crucial to establish their efficacy and safety in treating endometriosis pain.

Date :
  1. Date Completed 2007-10-18
  2. Date Revised 2020-05-11
Further Info :

Pubmed ID

17636631

DOI: Digital Object Identifier

10.1002/14651858.CD000346.pub2

Related Literature

Article Analysis
・Effective treatment of endometriosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.