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Antileukotriene drugs: clinical application, effectiveness and safety.

Author: BucciarelliT, D'OrazioN, Di IlioC, ManciniB, RiccioniG

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Leukotriene receptor antagonists (LTRAs) are effective in treating asthma and allergic rhinitis by blocking Cys-LT(1) receptors. Recent studies show that LTRAs are also beneficial in treating other diseases associated with asthma, such as exercise-induced asthma, rhinitis, and chronic obstructive pulmonary disease, and in diseases not related to asthma, such as migraine, cystic fibrosis, and vulvovaginal candidiasis.
Paper Details　
Original Abstract of the Article :
Cysteinyl leukotrienes (Cys-LTs) are potent proinflammatory mediators derived from arachidonic acid through the 5-lypoxigenase (5-LO) pathway. They exert important pharmacological effects by interaction with at least two different receptors: Cys-LT(1) and Cys-LT(2). By competitive binding to the Cys...See full text at original site
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引用元：
https://doi.org/10.2174/092986707781368522

データ提供：米国国立医学図書館（NLM）

Leukotrienes: A New Frontier in the Treatment of Allergies and Other Chronic Diseases

Leukotrienes are powerful inflammatory mediators that play a role in a variety of diseases, including asthma, allergic rhinitis, and even certain types of cancer. This research delves into the potential of leukotriene receptor antagonist drugs, such as montelukast, zafirlukast, and pranlukast, to effectively treat these conditions. The researchers provide a comprehensive overview of the clinical applications, effectiveness, and safety of these drugs.

Targeting Leukotrienes: A New Approach to Treating Chronic Diseases

This research highlights the potential of leukotriene receptor antagonist drugs to effectively manage a wide range of chronic diseases. These drugs, like skilled desert guides, can help navigate the complex landscape of inflammation and allergy, providing relief for patients suffering from these conditions.

Expanding the Reach of Leukotriene Receptor Antagonist Drugs

The research suggests that leukotriene receptor antagonist drugs may have broader therapeutic applications than previously thought. This expansion of their potential use is like discovering new pathways through a vast desert, opening up new possibilities for treating a variety of chronic diseases.

Dr.Camel's Conclusion

Leukotriene receptor antagonist drugs represent a promising new approach to treating chronic diseases. By targeting these inflammatory mediators, these drugs offer a potentially effective and well-tolerated treatment option for a range of conditions, including asthma, allergic rhinitis, and even certain types of cancer.

Date :
  1. Date Completed 2007-10-03
  2. Date Revised 2019-08-23
Further Info :

Pubmed ID

17691939

DOI: Digital Object Identifier

10.2174/092986707781368522

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Languages

English

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