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Macrolide resistance in the normal microbiota after Helicobacter pylori treatment.
Author: EngstrandLars, FallKatja, FjelstadBjörn, JakobssonHedvig, NyrénOlof, WreiberKarin
Original Abstract of the Article :
Large-scale chemoprevention of peptic ulcer disease and gastric cancer through eradication of Helicobacter pylori would expose large population groups to antibiotics, which raises concerns about possible dissemination of antibiotic resistance. The objective of this cohort study was to determine whet...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元:
https://doi.org/10.1080/00365540701299608
データ提供:米国国立医学図書館(NLM)
The Hidden Costs of H. pylori Eradication: Antibiotic Resistance
Imagine a vast desert ecosystem, delicate and balanced. Now picture a large-scale eradication campaign targeting a specific species, like a particular type of cactus. This is the scenario explored in this study, which focuses on the potential consequences of widespread eradication of the bacterium H. pylori, a common cause of peptic ulcer disease and gastric cancer. Eradicating H. pylori often involves a course of antibiotics, which raises concerns about the emergence of antibiotic resistance. The researchers conducted a cohort study, like a carefully observed oasis, to investigate whether a triple therapy containing omeprazole, clarithromycin, and metronidazole, used to combat H. pylori infection, might contribute to the spread of macrolide resistance in the normal microbiota, the diverse community of microorganisms that reside within our bodies. The findings painted a concerning picture, showing that the triple therapy indeed led to a persistent increase in macrolide resistance among various bacteria in the normal microbiota. This suggests a potential ecological hazard, like the spread of invasive species in the desert, that could impact the delicate balance of our internal ecosystem. The study highlights the importance of carefully considering the potential consequences of widespread antibiotic use, particularly in the context of global H. pylori eradication programmes.
Antibiotic Resistance: A Growing Threat in the Microbial World
The study found that a triple therapy for H. pylori eradication led to a persistent increase in macrolide resistance in the normal microbiota. This finding emphasizes the potential for large-scale antibiotic use to drive antibiotic resistance, a global health challenge that could jeopardize the effectiveness of antibiotics in the future.
Protecting Our Microbial Allies: A Call for Responsible Antibiotic Use
This study underscores the importance of prudent antibiotic use to protect our microbial allies and prevent the emergence of antibiotic resistance. It's a reminder that our bodies are intricate ecosystems, and just like a delicate desert ecosystem, they require careful stewardship to maintain their health and balance.
Dr.Camel's Conclusion
This study highlights the potential ecological hazard of widespread antibiotic use, specifically in the context of H. pylori eradication. The emergence of antibiotic resistance is a critical concern, and responsible antibiotic use is essential to preserve the efficacy of these vital medications.
Date :
- Date Completed 2007-12-18
- Date Revised 2013-11-21
Further Info :
Related Literature
English
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