Paper Details

  1. Home
  2. Paper Details

Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a prospective, randomized, controlled trial.

Author: AlticeFrederick L, BruceR Douglas, FriedlandGerald H, MaruDuncan Smith-Rohrberg, SpringerSandra A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Directly administered antiretroviral therapy (DAART) significantly improved 6-month virologic outcomes in HIV-infected drug users compared to self-administered therapy. A greater proportion of patients in the DAART group achieved the primary outcome (70.5% vs. 54.7%), with a larger mean reduction in HIV-1 RNA levels and mean increase in CD4+ T lymphocyte counts.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Directly administered antiretroviral therapy (DAART) is one approach to improve treatment adherence among human immunodeficiency virus (HIV)-infected drug users. METHODS: In this randomized, controlled trial (ClinicalTrials.gov identifier, NCT00367172), the biological outcomes of a 6-mo...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/17712763

データ提供：米国国立医学図書館（NLM）

Directly Administered Antiretroviral Therapy (DAART) for HIV-infected Drug Users

This research explored the effectiveness of directly administered antiretroviral therapy (DAART) in improving treatment adherence among HIV-infected individuals who use drugs. The study, conducted as a randomized controlled trial, compared the biological outcomes of DAART with self-administered therapy over a six-month period. The primary outcome was the proportion of patients achieving a significant reduction in HIV-1 RNA levels. The results showed that a significantly greater proportion of patients in the DAART group achieved the primary outcome compared to those receiving self-administered therapy. Additionally, patients receiving DAART experienced a greater mean reduction in HIV-1 RNA levels and a mean increase in CD4+ T lymphocyte counts.

DAART: A Promising Approach to HIV Treatment

The study's findings strongly support the use of DAART in HIV treatment programs targeting drug users with poor adherence to treatment. The study's conclusion that DAART can significantly improve virologic outcomes in this population is encouraging. The results demonstrate the potential of DAART to enhance HIV treatment adherence and improve patient outcomes.

Navigating HIV Treatment: A Collaborative Journey

This study emphasizes the importance of addressing the complex challenges faced by HIV-infected individuals who use drugs. It underlines the need for innovative approaches to treatment, such as DAART, to improve patient outcomes. Just as a caravan navigates the desert together, a collaborative approach between patients and healthcare professionals is essential in navigating the path towards better health and well-being.

Dr. Camel's Conclusion

This research underscores the importance of tailoring treatment strategies to individual needs and circumstances. DAART represents a promising approach to enhance treatment adherence and improve outcomes for HIV-infected individuals who use drugs. This study serves as a valuable reminder of the vital role research plays in developing effective treatments and improving the lives of those affected by complex medical conditions.
Date :
  1. Date Completed 2008-01-08
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17712763

DOI: Digital Object Identifier

NIHMS33251

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.