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Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial.

Author: ConleyRobert R, JungDo-Un, KellyDeanna L, LiuKwang-Hyeon, SeoYoung-Soo, ShimJoo-Cheol, ShinJae-Goo K, ShonJi-Hong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

Adjunctive aripiprazole treatment effectively reversed hyperprolactinemia in both men and women with schizophrenia, leading to the reinstatement of menstruation in female patients. This occurred without significant effects on psychopathology or extrapyramidal symptoms.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Hyperprolactinemia and associated side effects often occur with antipsychotics. The authors investigated the effect of adjunctive treatment with aripiprazole on hyperprolactinemia and psychopathology in patients with schizophrenia maintained with haloperidol. METHOD: Fifty-six patients w...See full text at original site
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引用元：
https://doi.org/10.1176/appi.ajp.2007.06071075

データ提供：米国国立医学図書館（NLM）

Aripiprazole: A Potential Solution for Antipsychotic-Induced Hyperprolactinemia

Antipsychotics, while effective in treating mental health conditions, can sometimes have unwanted side effects. One of these is hyperprolactinemia, an increase in prolactin levels. This study, published in [Journal Name], investigated the effectiveness of aripiprazole, a dopamine partial agonist, as an adjunctive treatment for hyperprolactinemia induced by haloperidol. It's like finding a way to tame a wild beast without losing its strength!

Aripiprazole's Role in Restoring Balance

The study found that aripiprazole significantly reduced prolactin levels in patients with hyperprolactinemia. This suggests that aripiprazole could be a valuable tool in managing this side effect of antipsychotics. The study also found that aripiprazole did not significantly affect psychopathology or extrapyramidal symptoms. This is important because it suggests that aripiprazole can address hyperprolactinemia without compromising the effectiveness of the primary antipsychotic.

Navigating the Side Effects of Mental Health Treatments

This research offers a glimmer of hope in the desert of mental health treatment side effects. While antipsychotics can be life-changing, managing their side effects is crucial. Aripiprazole shows promise as a safe and effective way to address hyperprolactinemia, making treatment more comfortable and effective for patients.

Dr. Camel's Conclusion

This research offers a valuable insight into managing the side effects of antipsychotic medications. It highlights the importance of finding ways to minimize unwanted effects while maximizing treatment effectiveness. Aripiprazole, a dopamine partial agonist, shows promise as a potential solution for hyperprolactinemia. Further research is essential to explore its long-term effects and potential for broader application.

Date :
  1. Date Completed 2007-10-09
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

17728426

DOI: Digital Object Identifier

10.1176/appi.ajp.2007.06071075

SNS
PICO Info
in preparation
Languages

English

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