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[A comparative study of the efficacy and tolerance of dipotassium clorazepate and flunitrazepam for oral premedication].

Author: DrautzM, FeuchtA, HeuserD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Flunitrazepam (F) and chlorazepate dipotassium (CD), two benzodiazepine derivatives, were effective in improving sleep quality, reducing anxiety, and providing amnesia in 108 women undergoing gynecological surgery. Both drugs were well tolerated, but F caused a significant decrease in preoperative oxygen saturation.
Paper Details　
Original Abstract of the Article :
The literature shows that benzodiazepines, in view of their anxiolytic, sedative, amnesic, muscle relaxant and anticonvulsive action, are the most important substances for premedication. Eminent workers regard anxiolysis as the most important aim of premedication. In the present clinical study, oral...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1781562

データ提供：米国国立医学図書館（NLM）

A Comparative Study of Premedication for Gynecological Surgery

[Premedication] is a crucial step in preparing patients for [surgery], aiming to [reduce anxiety and promote relaxation]. This research investigated the [efficacy and tolerance] of two [benzodiazepine derivatives], [flunitrazepam (F) and chlorazepate dipotassium (CD)], in [108 women undergoing gynecological surgery]. The study compared the [anxiolytic, sedative, and amnesic effects], as well as the [side effects and tolerance] of both drugs. The results indicated that [both F and CD improved sleep quality] and [reduced anxiety and sedation] compared to [no premedication]. However, [F had a greater impact on oxygen saturation (SaO2)] compared to [CD]. These findings suggest that [both drugs are effective premedication options] for [gynecological surgery] but with [different effects on physiological parameters].

Exploring the Landscape of Premedication

This study sheds light on the [diverse effects of benzodiazepines] as premedication, revealing [the nuanced differences between F and CD]. The results provide valuable information for [choosing the appropriate premedication] based on the [individual needs of the patient] and the [surgical procedure].

Preparing for Surgery: A Calm Approach

Imagine a journey across a vast desert, where the traveler prepares for the challenges ahead. This study explores the [role of premedication] in preparing patients for [surgery], ensuring a calm and comfortable experience. The research highlights the [importance of individualized care] when choosing premedication, tailoring the treatment to each patient's unique needs.

Dr. Camel's Conclusion

This research illuminates the importance of [carefully selecting premedication] for surgical procedures. Just as a desert traveler chooses the right supplies for the journey, doctors must consider the individual needs of their patients when selecting the appropriate premedication. This approach ensures a smoother and more comfortable experience for those embarking on the path of surgery.

Date :
  1. Date Completed 1992-03-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1781562

DOI: Digital Object Identifier

1781562

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Article Analysis
・Side Effects of clorazepate
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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