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Neoadjuvant chemotherapy in operable breast cancer.

Author: AsselainB, DorvalT, DurandJ C, Garcia GiraltE, JouveM, PalangieT, PouillartP, SchollS M, VilcoqJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared neoadjuvant chemotherapy (before surgery) to adjuvant chemotherapy (after surgery) in 196 patients with operable breast cancer. While neoadjuvant chemotherapy resulted in a greater tumor response, particularly for patients receiving higher doses, there was no significant difference in survival between the two groups. The study concluded that neoadjuvant chemotherapy was safe and at least as effective as adjuvant chemotherapy, supporting further research into chemotherapy as a first-line treatment option for breast cancer.
Paper Details　
Original Abstract of the Article :
Primary chemotherapy in localised breast cancer may prevent tumour spread during surgical treatment and reduce proliferation of micrometastases. A randomised clinical trial, in 196 premenopausal and postmenopausal patients with operable (T2-3, N0-1b) breast cancer, was started in November 1983 at th...See full text at original site
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引用元：
https://doi.org/10.1016/0277-5379(91)90442-g

データ提供：米国国立医学図書館（NLM）

A Proactive Approach: Neoadjuvant Chemotherapy in Breast Cancer

The fight against breast cancer is a battleground where researchers are constantly seeking to improve treatment strategies. This study explores the effectiveness of neoadjuvant chemotherapy, where chemotherapy is administered before surgery, for operable breast cancer. The researchers conducted a randomized clinical trial comparing neoadjuvant and adjuvant chemotherapy regimens, with or without surgery, in patients with operable breast cancer. Their findings suggest that neoadjuvant chemotherapy may be a safe and effective treatment option, potentially reducing tumor spread and improving survival rates. This research provides valuable insights into the potential benefits of a proactive approach to breast cancer treatment.

A Head Start in the Fight: Neoadjuvant Chemotherapy's Impact on Breast Cancer

The study's results show that neoadjuvant chemotherapy, when administered before surgery, may be a valuable tool in the fight against breast cancer. The researchers observed a significant association between tumor response and the dose of chemotherapy received, suggesting that dose optimization is crucial for achieving optimal treatment outcomes. While the study found a slight non-significant advantage for the neoadjuvant group in terms of survival, further research is needed to confirm these findings. The study highlights the importance of individualizing treatment approaches based on patient characteristics and tumor response.

A New Strategy for Prevention: Neoadjuvant Chemotherapy in Breast Cancer

Imagine preparing for a journey through a vast desert. By ensuring you have the necessary supplies and tools, you increase your chances of a successful expedition. Similarly, administering chemotherapy before surgery allows for a more proactive approach to breast cancer treatment, potentially reducing the risk of tumor spread and improving survival rates. This research encourages a shift towards a more preventative mindset in the fight against breast cancer.

Dr. Camel's Conclusion

This research provides valuable insights into the potential benefits of neoadjuvant chemotherapy in the treatment of breast cancer. The study suggests that this approach may be a safe and effective option, potentially reducing tumor spread and improving survival rates. The findings emphasize the importance of individualized treatment strategies and the potential of a proactive approach to fighting this disease.

Date :
  1. Date Completed 1992-03-17
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

1782080

DOI: Digital Object Identifier

10.1016/0277-5379(91)90442-g

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Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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