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[Apomorphine in off state--clinical experience].

Author: RudzińskaMonika, SzczudlikAndrzej

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Apomorphine is a dopamine receptor agonist used in Parkinson's disease to reduce the time of "off" phases by 50-72%. It is administered subcutaneously, with other routes like transdermal, sublingual, intranasal, rectal, and intravenous infusion also explored. Common side effects include nausea, vomiting, orthostatic hypotension, dyskinesias, sleep disturbances, hallucinations, delusions, edema, and yawning. Domperidone or trimethobenzamide can be used to reduce peripheral adverse events.
Paper Details　
Original Abstract of the Article :
Apomorphine, a non-ergot derivative, is a potent, directly acting dopamine receptor agonist with high affinity to D4, lower to D2, D3, D5, the lowest to D1-like dopamine receptors as well as to serotonin and adrenoreceptors. Subcutaneous apomorphine is currently used in Parkinson's disease as an add...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17941458

データ提供：米国国立医学図書館（NLM）

Apomorphine: A Beacon of Hope for Parkinson's Disease

This study investigates the use of apomorphine, a dopamine agonist, in managing Parkinson's disease. Imagine a camel struggling to navigate the shifting sands of the desert, its movements slow and unsteady. This study explores how apomorphine can help individuals with Parkinson's disease regain control and mobility.

A New Weapon in the Fight Against Parkinson's

The study found that apomorphine can significantly reduce the duration of 'off' phases in individuals with Parkinson's disease. These 'off' phases are periods of decreased mobility and functionality, like a camel struggling to move through a sandstorm. This research offers hope that apomorphine can help individuals with Parkinson's disease regain control and live more fulfilling lives.

A Journey Towards Improved Quality of Life

This study underscores the importance of exploring new treatment options for Parkinson's disease. It offers a beacon of hope for individuals struggling with the debilitating effects of this disease, paving the way for a more active and fulfilling life.

Dr.Camel's Conclusion

This research offers a glimmer of hope in the desert of Parkinson's disease, suggesting that apomorphine can help individuals regain control and mobility, allowing them to navigate the challenges of this condition with greater ease. It is a testament to the tireless efforts of researchers who strive to improve the lives of those affected by this debilitating disease.

Date :
  1. Date Completed 2007-11-27
  2. Date Revised 2015-02-16
Further Info :

Pubmed ID

17941458

DOI: Digital Object Identifier

17941458

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Article Analysis
・Side Effects of trimethobenzamide
SNS
PICO Info
in preparation
Languages

Polish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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