Side Effects of trimethobenzamide: A Synthesis of Findings from 7 Studies

  1. Home
  2. Side Effects of trimethobenzamide
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of trimethobenzamide: A Synthesis of Findings from 7 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of trimethobenzamide: A Synthesis of Findings from 7 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Trimethobenzamide has been shown to be effective in treating nausea and vomiting. 6 It has particularly demonstrated efficacy in reducing nausea and vomiting associated with chemotherapy, showing significant improvement compared to placebo over a 48-hour study. 6 It is also used to alleviate nausea and vomiting caused by apomorphine in treating Parkinson's disease. 5

Reasons for Side Effects

The side effects of trimethobenzamide are attributed to its pharmacological action. It suppresses the movement of muscles in the digestive tract and inhibits the vomiting center in the brain. These effects are believed to be the cause of side effects.

Common Side Effects

Drowsiness

The most common side effect of trimethobenzamide is drowsiness. 1 This side effect is likely due to the medication's action on the central nervous system.

Dizziness

Trimethobenzamide can cause dizziness. 1 This is because the medication can potentially affect the organs in the inner ear that regulate balance.

Fatigue

Trimethobenzamide can cause fatigue.

Constipation

Trimethobenzamide can cause constipation.

Dry mouth

Trimethobenzamide can cause dry mouth.

Visual disturbances

Trimethobenzamide can cause visual disturbances.

Gastrointestinal symptoms

Trimethobenzamide can cause gastrointestinal symptoms, such as nausea, vomiting, abdominal pain, and diarrhea. 1

Nervous system symptoms

Trimethobenzamide can cause nervous system symptoms such as headache, dizziness, lightheadedness, numbness, weakness, and muscle spasms.

Allergic reaction

Trimethobenzamide can cause allergic reactions.

Other side effects

In addition to the above, trimethobenzamide can potentially cause various other side effects.

Side Effect Management

Drowsiness

While taking trimethobenzamide, you should avoid activities that require alertness, such as driving or operating machinery.

Dizziness

If you experience dizziness, rest.

Gastrointestinal symptoms

If you have any concerns about gastrointestinal symptoms, consult your doctor.

Allergic reaction

If you experience an allergic reaction, seek immediate medical attention.

Comparison Across Studies

Commonalities Across Studies

Multiple studies have reported that trimethobenzamide is effective in treating nausea and vomiting. 6 5

Differences Across Studies

Side effects of trimethobenzamide may vary across studies.

Cautions for Application in Real Life

Take trimethobenzamide as directed by your doctor.

Current Research Limitations

The long-term safety and efficacy of trimethobenzamide are not yet fully understood.

Future Research Directions

Research is needed to assess the long-term safety and efficacy of trimethobenzamide.

Conclusion

Trimethobenzamide is a medication that can be effective in treating nausea and vomiting. However, it is important to take it as directed by your doctor because of the potential risk of side effects.

Literature analysis of 7 papers
Positive Content
7
Neutral Content
0
Negative Content
0
Article Type
2
0
0
3
7
1.

Double-blind crossover comparison of triazolam and lorazepam in the posthypnotic state.

Author: CohnJ B

Induces sleep
Daytime sleepiness
Side effects

Triazolam and lorazepam are both effective hypnotics, but lorazepam has more pronounced daytime carryover and side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

[Apomorphine in off state--clinical experience].

Author: RudzińskaMonika, SzczudlikAndrzej

Parkinson's disease treatment
Nausea
Orthostatic hypotension
Vomiting

Apomorphine is a dopamine receptor agonist used in Parkinson's disease to reduce the time of "off" phases by 50-72%. It is administered subcutaneously, with other routes like transdermal, sublingual, intranasal, rectal, and intravenous infusion also explored. Common side effects include nausea, vomiting, orthostatic hypotension, dyskinesias, sleep disturbances, hallucinations, delusions, edema, and yawning. Domperidone or trimethobenzamide can be used to reduce peripheral adverse events.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Polish

3.

Rapid treatment of "wearing off" in Parkinson's disease.

Author: SwopeDavid M

Improved motor function
Dyskinesias
Nausea
Orthostatic hypotension

This manuscript discusses "rescue" therapies for Parkinson's disease patients experiencing motor complications associated with levodopa therapy. It covers strategies for administering liquid levodopa and reviews other levodopa preparations under development. It also provides practical guidelines for the use of subcutaneous apomorphine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Practical considerations in the use of apomorphine injectable.

Author: BowronAnnette

Improved motor function
Confusion
Dyskinesia
Hallucinations
Hypersexuality
Nausea
Postural hypotension
Skin nodule formation
Somnolence

This article provides a practical guide to the use of subcutaneous apomorphine for Parkinson's disease patients experiencing "off" periods. It includes information on patient education, pre-treatment assessment, dose titration, and side effect management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Intranasal apomorphine rescue therapy for parkinsonian "off" periods.

Author: DeweyR B, MaraganoreD M, AhlskogJ E, MatsumotoJ Y

Ease of administration
Effective antiemetic for apomorphine
Rapid relief of Parkinsonian 'off' states
Nausea and vomiting
Orthostatic hypotension

This open-label study evaluated the efficacy and safety of intranasal apomorphine in 11 patients with levodopa-related motor fluctuations in Parkinson's disease. Intranasal apomorphine was found to be effective in rapidly relieving "off" states, with a similar magnitude of motor improvement compared to levodopa/carbidopa. The most common side effects were nausea and vomiting, effectively managed with trimethobenzamide. Intranasal apomorphine offers a rapid and convenient treatment option for managing "off" states in Parkinson's disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines.

Author: FriedmanBenjamin W, HochbergMichael, EssesDavid, BijurPolly E, CorboJill, PaternosterJoseph, SolorzanoClemencia, ToosiBabak, LiptonRichard B, GallagherE John

Improved migraine treatment
Migraine

While various medications are used in the emergency department (ED) to treat acute migraines, none provide complete pain relief without side effects or headaches coming back. Even though anti-nausea medications and sumatriptan injections have shown effectiveness, there's still a need for better treatments given through injection. Early studies suggest that combining trimethobenzamide and diphenhydramine might be effective for a large percentage of migraine sufferers.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.