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Biochemical short-term changes produced by hormonal replacement therapy.

Author: AloiaJ F, McGowanD M, RossP, VaswaniA, YehJ K

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the effects of estrogen-progestin therapy, calcium supplementation, and a combination of both on bone metabolism in 71 postmenopausal women. While estrogen therapy led to significant changes in bone metabolism markers, including a decrease in bone turnover and an increase in calcium-regulating hormones, calcium supplementation alone did not significantly affect these markers. The study suggests that estrogen therapy may be more effective than calcium supplementation alone in improving bone health, and that further research is needed to assess the effects of higher calcium intake and the potential for additive effects of both treatments.
Paper Details　
Original Abstract of the Article :
Seventy-one white women within 6 months to 6 years postmenopause were randomly assigned to three treatment groups: (a) placebo, (b) calcium, (c) cyclic estrogen-progestin plus calcium. Calcium was given as calcium carbonate with meals to attain an intake of 1,700 mg daily in the latter two groups. A...See full text at original site
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引用元：
https://doi.org/10.1007/BF03347118

データ提供：米国国立医学図書館（NLM）

Hormonal Replacement Therapy: A Journey Through Bone Remodeling

The process of bone remodeling is a complex dance, much like the shifting sands of a desert. This study examines the short-term effects of hormonal replacement therapy (HRT) on bone metabolism. The authors, like patient observers, document the changes in various bone markers and hormonal levels.

Hormonal Effects: A Delicate Balance

The study found that HRT led to significant changes in several bone markers, including calcium, osteocalcin, and urinary hydroxyproline. These findings suggest that HRT can impact bone remodeling, although the exact mechanisms are still being explored.

Balancing the Scales: Hormones and Bone Health

The authors highlight the need for further research to understand the long-term effects of HRT on bone health. Just as a camel needs to find a balance between water and food sources, individuals considering HRT need to weigh the potential benefits and risks for their overall well-being.

Dr. Camel's Conclusion

This study provides a glimpse into the complex interplay of hormones and bone remodeling. It emphasizes the importance of careful monitoring and personalized treatment strategies for individuals considering HRT. Further research is crucial to fully understand the long-term effects of this therapy on bone health and to develop more targeted and effective treatments.

Date :
  1. Date Completed 1992-05-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

1806610

DOI: Digital Object Identifier

10.1007/BF03347118

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PICO Info
in preparation
Languages

English

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