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Treatment of primary and secondary osteoarthritis of the knee.

Author: AronsonNaomi, BonnellClaudia J, GrantMark D, RatkoThomas A, SamsonDavid J, ZieglerKathleen M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The evidence for the clinical benefit of viscosupplementation, oral glucosamine/chondroitin, and arthroscopic lavage or debridement for osteoarthritis of the knee is uncertain. Further rigorous, multicenter randomized controlled trials are needed to evaluate these interventions.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Systematic review of outcomes of three treatments for osteoarthritis (OA) of the knee: intra-articular viscosupplementation; oral glucosamine, chondroitin or the combination; and arthroscopic lavage or debridement. DATA SOURCES: We abstracted data from: 42 randomized, controlled trials ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781439/

データ提供：米国国立医学図書館（NLM）

Osteoarthritis of the Knee: A Quest for Effective Treatments

Osteoarthritis (OA) is a common and debilitating condition that affects millions of people worldwide. This research reviews the evidence for three commonly used treatments for OA of the knee: viscosupplementation, oral glucosamine and chondroitin, and arthroscopic lavage or debridement.

The researchers found that while viscosupplementation showed some positive effects, the evidence for its clinical benefit was uncertain due to methodological limitations. They concluded that the large, high-quality Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) did not support the use of glucosamine and chondroitin for OA. Additionally, the best available evidence for arthroscopy suggested that it was no more effective than placebo.

Navigating the Arid Landscape of Osteoarthritis Treatments

This research emphasizes the need for rigorous scientific evidence to guide treatment decisions for OA of the knee. The researchers highlighted the lack of strong evidence supporting the effectiveness of commonly used interventions. This underscores the importance of ongoing research to develop more effective and evidence-based treatment options for this debilitating condition.

Dr.Camel's Conclusion

Osteoarthritis can feel like a grueling desert trek, with joint pain and limited mobility. This research highlights the importance of navigating this landscape with scientific evidence, rather than relying on unproven remedies. As we continue to explore new treatments for OA, we can pave a smoother path for those affected by this debilitating condition.

Date :
  1. Date Completed 2008-01-23
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

18088162

DOI: Digital Object Identifier

PMC4781439

Related Literature

Article Analysis
・Effective treatment of osteoarthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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