Effective treatment of osteoarthritis: A Synthesis of Findings from 131 Studies

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Original Abstract of the Article

Key Research Findings

Osteoarthritis (OA) is a common joint disease that can cause pain, stiffness, and limited mobility. While there is no cure for OA, research has shown that conservative treatments can effectively manage symptoms and slow disease progression.

For example, a study published in 2020 ( 103 ) found that implementing an evidence-based conservative care program for knee osteoarthritis resulted in meaningful functional improvements. Another study ( 78 ) highlighted the widespread use of manual therapy as a physical treatment for knee osteoarthritis to alleviate pain, stiffness, and dysfunction. Aquatic exercise has also shown promise as a treatment for OA, as indicated by a 2013 review ( 68 ), which suggested its benefits for individuals with knee and hip osteoarthritis. Exercise therapy is another commonly used modality for OA, as reported in a 2004 study ( 9 ). However, a randomized controlled trial ( 8 ) demonstrated the ineffectiveness of acetaminophen in alleviating knee osteoarthritis pain. Further research ( 49 ) suggests that specific OA phenotypes may benefit significantly from bone-acting agents.

Treatment Summary

These studies demonstrate the use of a variety of treatment approaches for osteoarthritis, ranging from medication to physical therapy and even aquatic exercise.

For instance, the 2020 study ( 103 ) employed an evidence-based conservative care program. Manual therapy was utilized in the study from 2015 ( 78 ). Aquatic exercise was employed in the 2013 review ( 68 ). Exercise therapy was the focus of the 2004 study ( 9 ). Acetaminophen was the treatment of choice in the 2003 trial ( 8 ). The 2011 research ( 49 ) explored the potential benefits of bone-acting agents.

Benefits and Risks

Benefits Summary

Osteoarthritis treatments offer a range of benefits, but it's important to understand both the advantages and potential drawbacks. Conservative treatments, compared to surgery, generally carry lower risks. However, it's crucial to note that not all patients experience positive outcomes from these treatments.

Risks Summary

Treatment for osteoarthritis can come with side effects. For example, medication may cause gastrointestinal side effects. Surgical procedures, on the other hand, pose risks such as infection and bleeding. A 2019 study ( 97 ) expressed concerns about the long-term safety implications of commonly used OA treatments.

Comparison Across Studies

Commonalities Across Studies

Across these studies, a common theme emerges: the use of various approaches to manage osteoarthritis, including exercise therapy, medication, and other modalities.

Differences Across Studies

Due to variations in patient populations, treatment methods, and evaluation techniques, a direct comparison of the results from these studies is not feasible.

Consistency and Inconsistencies in Findings

These studies collectively suggest that effective methods exist for treating osteoarthritis. However, it is important to acknowledge that not every patient responds to these treatments in the same way. Additionally, the risk of side effects varies depending on the specific treatment approach. Therefore, selecting the most appropriate treatment for each patient's unique condition and needs is crucial.

Considerations for Real-World Application

While these research findings can offer valuable guidance for osteoarthritis management, it's important to remember that these studies often target specific patient populations and may not apply universally. Consulting with a healthcare professional to discuss the most suitable treatment options for your individual circumstances is essential.

Limitations of Current Research

The research on OA treatments faces limitations, including:

  • Limited patient populations in some studies, making it challenging to generalize findings to all patients with OA.
  • Variations in treatment approaches and evaluation methods, hindering direct comparisons across studies.
  • Short study durations in some cases, leaving long-term effects unknown.

Future Directions for Research

Further research is essential to enhance our understanding of osteoarthritis treatments. Areas of particular importance include:

  • Long-term safety and efficacy studies of existing treatments.
  • Comparative studies to assess the effectiveness of different treatment options.
  • Development of personalized treatment plans tailored to individual patient needs and conditions.

Conclusion

The research on osteoarthritis treatments reveals the existence of several effective approaches, although these may not be universally applicable. The risks of side effects vary depending on the chosen treatment, making personalized care crucial. Continued research is necessary to further explore long-term safety, efficacy, and personalized treatment options for OA.

Treatment Keywords

Conservative treatment, exercise therapy, manual therapy, aquatic exercise, medication, bone-acting agents, hyaluronic acid, corticosteroids, viscosupplementation, intra-articular injections, foot orthoses, prolotherapy, acupuncture, auricular bean pressing, prehabilitation, weight management, patient education.

Keywords
Benefit Keywords
Improved walking distance
Osteoarthritis treatment
2
Improved pain
Improved physical function
Improved stiffness
3
Osteoarthritis prevention
Reduced disability
Reduced pain
4
Improved symptoms
Osteoarthritis treatment
Reduced joint space narrowing
5
Effective on-demand dosing
Less GI side effects
Similar pain relief
6
Improved aerobic capacity
Improved functional status
Improved gait
Reduced pain
9
Improved movement
Reduced pain
10
Reduced osteoarthritis pain
11
Improved knee function
Reduced knee pain
12
Improved knee function
Reduced knee pain
13
Osteoarthritis treatment
14
Osteoarthritis treatment
15
Function improvement
Pain reduction
16
Pain reduction
17
Osteoarthritis symptom relief
18
Pain relief
19
Hip OA treatment
20
Function improvement
Pain reduction
21
Improved hip osteoarthritis treatment
22
Osteoarthritis treatment
24
Osteoarthritis treatment
25
Improved Function
Reduced Pain
26
Improved Joint Space Narrowing
27
Improved function
Improved pain
28
Improved function
Improved pain
29
Delayed OA progression
Improved neuromuscular function
30
Osteoarthritis treatment
31
Improved function
32
Improved osteoarthritis treatment
33
Hip osteoarthritis treatment
34
Increased mobility
Reduced pain
Reduced swelling
35
Improved KOA treatment
36
Delayed joint replacement
Pain relief
37
Reduced OA pain
38
Improved locomotion
Improved pain
39
Knee OA treatment
40
Aerobic exercise improves disability
Aerobic exercise reduces pain
Strengthening exercise reduces pain
Ultrasonography reduces pain
41
Osteoarthritis treatment
42
Pain reduction
44
OA treatment
45
Mobility improvement
Pain reduction
Quality of life improvement
46
OA pain management
47
Osteoarthritis treatment
48
Antiresorptive drugs
49
Improved function
Reduced THR need
50
KineSpring Knee Implant
51
Osteoarthritis treatment
52
OA treatment
53
Hip OA function
Hip OA pain relief
54
Orthoses
55
Hyaluronic acid OA pain
IA treatments OA pain
56
OA treatment
58
Joint replacement
Osteoarthritis treatment
59
Arthrodesis
Arthroplasty designs
Joint-sparing surgery
60
Reduced pain
Sensitization
61
Improved function
Improved pain
63
Improved function
Reduced pain
64
Knee OA treatment
65
Knee OA treatment
67
Aquatic exercise for osteoarthritis
68
Function improvement
Pain reduction
69
Improved function
70
Knee OA treatment
71
OA treatment
72
Knee OA treatment
73
OA treatment
74
Improved hand osteoarthritis symptoms
Improved quality of life
75
OA treatment
77
Improved KOA function
Reduced KOA pain
Reduced KOA stiffness
78
Osteoarthritis treatment
79
Improved function
Improved pain
Increased ROM
80
Knee osteoarthritis treatment
81
Function improvement
Pain reduction
82
Knee osteoarthritis treatment
Nonoperative modalities
83
Improved function
Improved pain
84
Improved activity
Improved quality of life
85
Improved function
Improved pain
Long-term benefit
Short-term benefit
86
Reduced knee pain
87
Improved function
88
Symptomatic efficacy for knee OA
89
Pain reduction
90
Improved OA treatment
91
Improved osteoarthritis
Safe massage
Short-term relief
92
CS
HA
IA therapies
KOA treatment
PRP
93
Preoperative exercise
TKA treatment
94
Dietary intervention
Knee osteoarthritis treatment
95
CAM
Knee OA treatment
96
Improved treatment options
Long-term safety assessment
97
OA treatment
98
Improved knee osteoarthritis treatment
99
Pain and function improvement
100
Alternative treatment
101
Improved knee osteoarthritis treatment
102
Functional improvement
Knee osteoarthritis management
103
Improved quality of life
Sustained pain relief
104
Improved knee osteoarthritis treatment
105
knee osteoarthritis pain reduction
knee osteoarthritis psychological improvement
106
Improved knee osteoarthritis
Osteoarthritis treatment
107
Improved function
OA pain relief
108
Improved lifestyle
Pain relief
109
Improved function
Reduced pain
110
Functional improvement
Pain relief
111
Improved function
Reduced pain
112
Function improvement
Pain reduction
113
KOA treatment
114
Improved knee OA
115
Nonarthroplasty treatment for osteoarthritis of the knee
116
OA treatment
117
Acupuncture and massage benefits
KOA treatment
118
HBE benefits
KOA treatment
119
Predictive tool for response
120
Functional improvement
Pain relief
121
Improved knee ROM
Reduced pain
122
KOA treatment
124
KOA pain relief
Knee function
125
KOA treatment
126
Gene therapy for OA
127
Improved postoperative outcomes
128
OA treatment
129
Functionality improvement
Knee osteoarthritis treatment
130
KOA treatment
PRP efficacy
131
Risk Keywords
None reported
2
Local reactions
12
Local reactions
13
Local reactions
16
Insufficient evidence
Low quality studies
19
Osteoarthritis
22
No benefit over physical therapy
23
Opioid safety
25
Adverse Events
26
Adverse Events
27
Limited safety data
Placebo effects
28
Limited data
More research needed
45
Functional impairment
OA pain
47
Lack of research
48
Osteoarthritis
49
No pain/stiffness benefit
50
Knee osteoarthritis
55
Acetaminophen ineffective
IA corticosteroids not effective
56
No additional benefit
57
Arthroscopic debridement ineffectiveness
62
Ineffective treatment
66
Regenerative medicine
67
OA progression
74
NSAID side effects
Opiate side effects
79
Total knee arthroplasties
83
Heterogeneous cost-effectiveness estimates
No efficacy for disease modification
89
Side effects of chemical medications
96
Joint replacements
Joint safety events
100
Controversial efficacy
101
OA progression
108
No improvement in functionality
109
Cartilage toxicity
Increased blood glucose
Increased infections
Reduced immune function
110
None reported
122
Hip OA
Knee OA
123
Literature analysis of 131 papers
Positive Content
116
Neutral Content
8
Negative Content
7
Article Type
58
39
60
50
130
1.

Therapeutic trials in digital osteoarthritis. A critical review.

Author: TrêvesR, MaheuE, DreiserR L

Hand osteoarthritis is a common condition but is not often studied in clinical trials. A review of 13 trials conducted between 1983 and 1994 found that NSAIDs, SYSADOA, and miscellaneous agents were tested. The trials suggest that better standardized trials are needed to identify effective treatments for hand osteoarthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

2.

Effectiveness of manual physical therapy and exercise in osteoarthritis of the knee. A randomized, controlled trial.

Author: DeyleG D, HendersonN E, MatekelR L, RyderM G, GarberM B, AllisonS C

Improved walking distance
Osteoarthritis treatment
None reported

A combination of manual physical therapy and supervised exercise yielded functional benefits for patients with osteoarthritis of the knee.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Double blind randomized placebo control trial of controlled release codeine in the treatment of osteoarthritis of the hip or knee.

Author: PelosoP M, BellamyN, BensenW, ThomsonG T, HarsanyiZ, BabulN, DarkeA C

Improved pain
Improved physical function
Improved stiffness

Controlled-release codeine was effective in treating pain due to osteoarthritis of the hip or knee.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Osteoarthritis: new insights. Part 2: treatment approaches.

Author: FelsonD T, LawrenceR C, HochbergM C, McAlindonT, DieppeP A, MinorM A, BlairS N, BermanB M, FriesJ F, WeinbergerM, LorigK R, JacobsJ J, GoldbergV

Osteoarthritis prevention
Reduced disability
Reduced pain

Osteoarthritis, a common joint condition, is influenced by both genetic and lifestyle factors. This article discusses treatment approaches for osteoarthritis, focusing on both conventional and alternative therapies. Common medications, nutriceuticals, acupuncture, exercise, braces, and behavioral therapies are reviewed. Current surgical options are discussed, along with potential future treatments using biotechnology.

Consensus Development ConferenceA conference organized by the National Institutes of Health (NIH) to develop consensus and recommendations on medical issues.
Consensus Development Conference, NIHA conference organized by the NIH (National Institutes of Health) to develop consensus and recommendations on medical issues.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.

Author: ReginsterJ Y, DeroisyR, RovatiL C, LeeR L, LejeuneE, BruyereO, GiacovelliG, HenrotinY, DacreJ E, GossettC

Improved symptoms
Osteoarthritis treatment
Reduced joint space narrowing

This study found that glucosamine sulfate significantly slowed the progression of osteoarthritis joint structure changes and improved symptoms in patients with knee osteoarthritis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis.

Author: FioravantiAntonella, StorriLara, Di MartinoStefania, BisognoStefania, OldaniVirginio, ScottiAurelio, MarcolongoRoberto

Effective on-demand dosing
Less GI side effects
Similar pain relief

Nimesulide-beta-cyclodextrin provides similar pain relief to naproxen in the management of OA of the hip and/or knee and is associated with fewer gastrointestinal adverse reactions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Clinical benefit of joint distraction in the treatment of severe osteoarthritis of the ankle: proof of concept in an open prospective study and in a randomized controlled study.

Author: MarijnissenAnne C A, Van RoermundPeter M, Van MelkebeekJan, SchenkWillem, VerboutAbraham J, BijlsmaJohannes W J, LafeberFloris P J G

Joint distraction, a new treatment for severe osteoarthritis of the ankle, is being investigated for its efficacy in modifying the disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium.

Author: CaseJohn P, BaliunasAlgis J, BlockJoel A

Acetaminophen is recommended for the initial treatment of symptomatic osteoarthritis (OA) of the hip or knee due to its lower toxicity and perceived equal analgesic efficacy to nonsteroidal anti-inflammatory drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

Intensity of exercise for the treatment of osteoarthritis.

Author: BrosseauL, MacLeayL, RobinsonV, WellsG, TugwellP

Improved aerobic capacity
Improved functional status
Improved gait
Reduced pain

Both high-intensity and low-intensity aerobic exercise appear to be equally effective in improving functional status, gait, pain, and aerobic capacity in people with osteoarthritis (OA) of the knee. Further research with larger sample sizes and control groups is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Thermotherapy for treatment of osteoarthritis.

Author: BrosseauL, YongeK A, RobinsonV, MarchandS, JuddM, WellsG, TugwellP

Improved movement
Reduced pain

Osteoarthritis (OA) is a joint disease that primarily affects weight-bearing joints, especially knees and hips. It causes pain and restricted movement. Sometimes inflammation also occurs, leading to swelling. Treatment aims to reduce pain and improve mobility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Comparative evaluation of the effectiveness and tolerability of nimesulide versus rofecoxib taken once a day in the treatment of patients with knee osteoarthritis.

Author: HerreraJosé Antonio, GonzálezMaría

Reduced osteoarthritis pain

This trial compared the effectiveness of two nonsteroidal antiinflammatory drugs taken once daily to relieve osteoarthritis symptoms, finding that they were equally effective in reducing pain and stiffness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Viscosupplementation for the treatment of osteoarthritis of the knee.

Author: BellamyN, CampbellJ, RobinsonV, GeeT, BourneR, WellsG

Improved knee function
Reduced knee pain
Local reactions

Viscosupplementation is an effective treatment for osteoarthritis of the knee, particularly for pain relief at 5 to 13 weeks post-injection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Intraarticular corticosteroid for treatment of osteoarthritis of the knee.

Author: BellamyN, CampbellJ, RobinsonV, GeeT, BourneR, WellsG

Improved knee function
Reduced knee pain
Local reactions

Intra-articular corticosteroids provide short-term benefit for pain relief in osteoarthritis of the knee, but longer-term benefits have not been confirmed. Hyaluronan products appear to be more effective than corticosteroids for pain and function over time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Exercise as a treatment for osteoarthritis.

Author: BennellKim, HinmanRana

Osteoarthritis treatment

This review summarizes recent research, future directions, and clinical applications of exercise for knee osteoarthritis, highlighting its potential for symptom relief and slowing disease progression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Greater reduction of knee than hip pain in osteoarthritis treated with naproxen, as evaluated by WOMAC and SF-36.

Author: SvenssonO, MalmenäsM, FajutraoL, RoosE M, LohmanderL S

Osteoarthritis treatment

A study compared the improvement of knee and hip osteoarthritis during treatment with naproxen. Patients with knee osteoarthritis showed greater improvement compared to patients with hip osteoarthritis. Further research is needed to investigate the differences in treatment efficacy between these two conditions.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Viscosupplementation for the treatment of osteoarthritis of the knee.

Author: BellamyN, CampbellJ, RobinsonV, GeeT, BourneR, WellsG

Function improvement
Pain reduction
Local reactions

Viscosupplementation is an effective treatment for OA of the knee with beneficial effects on pain, function and patient global assessment, especially at the 5 to 13 week post injection period. However, there are few randomized head-to-head comparisons of different viscosupplements. The clinical effect for some products, against placebo, on some variables at some timepoints is in the moderate to large effect-size range.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Intraarticular corticosteroid for treatment of osteoarthritis of the knee.

Author: BellamyN, CampbellJ, RobinsonV, GeeT, BourneR, WellsG

Pain reduction

IA corticosteroid was more effective than IA placebo for pain reduction and patient global assessment at one week post injection. There was a lack of evidence of effect on pain and function at four to 24 weeks post injection. The response to HA products appears more durable than the response to IA corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Oxaceprol--a randomised, placebo-controlled clinical study in osteoarthritis with a non-conventional non-steroidal anti-inflammatory drug.

Author: KrügerK, KlasserM, MössingerJ, BeckerU

Osteoarthritis symptom relief

Oxaceprol was shown to be statistically significant and clinically relevant in the treatment of symptomatic osteoarthritis of the knee or hip.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

WITHDRAWN: Non-aspirin, non-steroidal anti-inflammatory drugs for treating osteoarthritis of the knee.

Author: WatsonM, BrookesS T, FaulknerA, KirwanJ

Pain relief
Insufficient evidence
Low quality studies

No substantial evidence is available related to efficacy, to distinguish between equivalent recommended doses of NSAIDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

What is the evidence for viscosupplementation in the treatment of patients with hip osteoarthritis? Systematic review of the literature.

Author: van den BekeromMichel P J, LammeBas, SermonAn, MulierMichiel

Hip OA treatment

Viscosupplementation (VS) is a treatment modality for osteoarthritis (OA) of the hip, but its efficacy requires further evaluation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Treatment of primary and secondary osteoarthritis of the knee.

Author: SamsonDavid J, GrantMark D, RatkoThomas A, BonnellClaudia J, ZieglerKathleen M, AronsonNaomi

Function improvement
Pain reduction

The evidence for the clinical benefit of viscosupplementation, oral glucosamine/chondroitin, and arthroscopic lavage or debridement for osteoarthritis of the knee is uncertain. Further rigorous, multicenter randomized controlled trials are needed to evaluate these interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Analgesic effectiveness of celecoxib and diclofenac in patients with osteoarthritis of the hip requiring joint replacement surgery: a 12-week, multicenter, randomized, double-blind, parallel-group, double-dummy, noninferiority study.

Author: EmeryPaul, KonczTamas, PanSharon, LowrySimon

Improved hip osteoarthritis treatment
Osteoarthritis

Osteoarthritis (OA) of the hip, affecting 3-11% of people over 35, causes pain, disability, and reduced quality of life. Treatment depends on the severity of pain and limitations. Common medications for hip OA include acetaminophen (recommended as a first-line treatment), NSAIDs like diclofenac, and specific types of NSAIDs like celecoxib.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

A randomized trial of arthroscopic surgery for osteoarthritis of the knee.

Author: KirkleyAlexandra, BirminghamTrevor B, LitchfieldRobert B, GiffinJ Robert, WillitsKevin R, WongCindy J, FeaganBrian G, DonnerAllan, GriffinSharon H, D'AscanioLinda M, PopeJanet E, FowlerPeter J

No benefit over physical therapy

Arthroscopic surgery for osteoarthritis of the knee did not show additional benefits compared to optimized physical and medical therapy in a randomized controlled trial. After 2 years, the mean WOMAC score was similar in both the surgery and control groups.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis of the hip or knee: protocol of a prospective randomised controlled clinical trial.

Author: SchenckingMartin, OttoAdriane, DeutschTobias, SandholzerHagen

Osteoarthritis treatment

Osteoarthritis is becoming more common as people live longer, impacting health and finances. While there is no cure, treatments focus on pain control and improving function. Hydrotherapy (water therapy) with alternating hot and cold water has been shown to improve movement, reduce pain, and enhance quality of life for up to three months. Weight loss is also important for hip and knee osteoarthritis. Physical therapy and exercise have been proven to be cost-effective and provide long-term benefits for pain, mobility, and quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Oral or transdermal opioids for osteoarthritis of the knee or hip.

Author: NüeschEveline, RutjesAnne Ws, HusniElaine, WelchVivian, JüniPeter

Osteoarthritis treatment
Opioid safety

This review discusses the use of opioids for osteoarthritis pain, acknowledging conflicting evidence regarding their effectiveness and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

S-Adenosylmethionine for osteoarthritis of the knee or hip.

Author: RutjesAnne Ws, NüeschEveline, ReichenbachStephan, JüniPeter

Improved Function
Reduced Pain
Adverse Events

S-Adenosylmethionine (SAMe) may be effective in treating pain and improving function in patients with osteoarthritis, but more research is needed. The quality of studies was poor. SAMe may have small, clinically relevant effects, but routine use is not advised.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Doxycycline for osteoarthritis of the knee or hip.

Author: NüeschEveline, RutjesAnne Ws, TrelleSven, ReichenbachStephan, JüniPeter

Improved Joint Space Narrowing
Adverse Events

Doxycycline did not show any significant symptomatic benefit in patients with osteoarthritis. The small benefit in terms of joint space narrowing was outweighed by safety problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Acupuncture for peripheral joint osteoarthritis.

Author: ManheimerEric, ChengKe, LindeKlaus, LaoLixing, YooJunghee, WielandSusan, van der WindtDaniëlle Awm, BermanBrian M, BouterLex M

Improved function
Improved pain
Limited safety data
Placebo effects

Sham-controlled trials show statistically significant benefits; however, these benefits are small, do not meet our pre-defined thresholds for clinical relevance, and are probably due at least partially to placebo effects from incomplete blinding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT.

Author: SawitzkeAllen D, ShiHelen, FincoMartha F, DunlopDorothy D, HarrisCrystal L, SingerNora G, BradleyJohn D, SilverDavid, JacksonChristopher G, LaneNancy E, OddisChester V, WolfeFred, LisseJeffrey, FurstDaniel E, BinghamClifton O, RedaDomenic J, MoskowitzRoland W, WilliamsH James, CleggDaniel O

Improved function
Improved pain

Over two years, no treatment (glucosamine, chondroitin sulfate, combined glucosamine/chondroitin, celecoxib, or placebo) achieved a clinically important difference in pain or function compared to placebo in patients with knee osteoarthritis. While glucosamine and celecoxib showed trends towards benefit, these were not statistically significant. Adverse reactions were similar among treatment groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

30.

Whole body vibration compared to conventional physiotherapy in patients with gonarthrosis: a protocol for a randomized, controlled study.

Author: SteinGregor, KnoellPeter, FaymonvilleChristoph, KaulhausenThomas, SieweJan, OttoChristina, EyselPeer, ZarghooniKourosh

Delayed OA progression
Improved neuromuscular function

This article discusses the use of whole body vibration as a modification of conventional physiotherapy for osteoarthritis (OA).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Therapy of the osteoarthritis of the temporomandibular joint.

Author: MachonVladimir, HirjakDusan, LukasJindrich

Osteoarthritis treatment

This study compared different treatment options for osteoarthritis of the jaw joint (temporomandibular joint, TMJ). The study found that a combination of injecting fluid into the joint (arthrocentesis) and using a splint was the most effective treatment, with 80% of patients experiencing significant improvement 3 months after treatment. Other treatments like limiting jaw movement, pain medication, and splints alone showed less improvement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Surgery for shoulder osteoarthritis.

Author: SinghJasvinder A, SperlingJohn, BuchbinderRachelle, McMakenKelly

Improved function

A review of 7 studies involving 238 patients compared surgical techniques for osteoarthritis of the shoulder. Total shoulder arthroplasty showed an advantage in terms of shoulder function but no other clinical benefits compared to hemiarthroplasty. Further studies are needed to compare clinical outcomes of different surgical techniques and components, as well as to compare surgery to non-surgical treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Comparison of intra-articular injections of hyaluronic acid and corticosteroid in the treatment of osteoarthritis of the hip in comparison with intra-articular injections of bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors.

Author: ColenSascha, van den BekeromMichel P J, BellemansJohan, MulierMichiel

Improved osteoarthritis treatment

This article discusses the need for more rigorously designed studies on hip osteoarthritis treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Non-surgical treatment of hip osteoarthritis. Hip school, with or without the addition of manual therapy, in comparison to a minimal control intervention: protocol for a three-armed randomized clinical trial.

Author: PoulsenErik, ChristensenHenrik W, RoosEwa M, VachWerner, OvergaardSøren, HartvigsenJan

Hip osteoarthritis treatment

Hip osteoarthritis is a common condition that causes pain, difficulty with movement, and reduced quality of life. Early treatment typically involves a combination of non-medication and medication approaches. Studies have shown that exercise therapy is beneficial, and some studies suggest that a hip school (patient education) and manual therapy are also promising interventions, potentially even more effective than exercise alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

[Physical therapy in osteoarthritis].

Author: GnjidićZoja

Increased mobility
Reduced pain
Reduced swelling

Physical therapy is important for treating rheumatic diseases, aiming to reduce pain, swelling, and keep joints moving. Managing osteoarthritis involves both non-medication and medication approaches. Physical therapy is part of a multi-treatment approach. This review of research on physical therapy for osteoarthritis, published between 2000 and 2010, found strong evidence supporting its use to improve movement, reduce pain and disability, decrease medication use, and enhance overall function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Croatian

36.

Immediate effect of the elastic knee sleeve use on individuals with osteoarthritis.

Author: BrykFlavio Fernandes, JesusJulio Fernandes de, FukudaThiago Yukio, MoreiraEsdras Gonçalves, MarcondesFreddy Beretta, SantosMarcio Guimarães dos

Improved KOA treatment

This study discusses the use of knee sleeves as an adjuvant treatment for knee osteoarthritis (KOA), recognizing the varying opinions on their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Surgical treatment for early osteoarthritis. Part II: allografts and concurrent procedures.

Author: GomollA H, FilardoG, AlmqvistF K, BugbeeW D, JelicM, MonllauJ C, PudduG, RodkeyW G, VerdonkP, VerdonkR, ZaffagniniS, MarcacciM

Delayed joint replacement
Pain relief

Cartilage repair is becoming increasingly attractive for young patients with early osteoarthritis due to its potential for pain relief and slowing disease progression, potentially delaying or eliminating the need for joint replacement. This review discusses the emerging technologies in cartilage repair and the importance of concurrent procedures like meniscal transplantation and osteotomy for optimizing outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Efficacy of a comprehensive rehabilitation programme combined with pharmacological treatment in reducing pain in a group of OA patients on a waiting list for total joint replacement.

Author: CasaleRoberto, DamianiCarlo, RosatiVanessa, AtzeniFabiola, Sarzi-PuttiniPiercarlo, NicaAdriana S

Reduced OA pain

Combined rehabilitation and pharmacological treatment reduced pain in patients with osteoarthritis (OA) awaiting total joint replacement (TJR), suggesting that both therapies are beneficial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis.

Author: VandeweerdJ-M, CoisnonC, CleggP, CambierC, PiersonA, HontoirF, SaegermanC, GustinP, BuczinskiS

Improved locomotion
Improved pain

Omega-3 fatty acid supplementation may be effective in treating osteoarthritis (OA) in dogs, but evidence for other nutraceuticals is poor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Ultrasound-guided aspiration and corticosteroid injection compared to horizontal therapy for treatment of knee osteoarthritis complicated with Baker's cyst: a randomized, controlled trial.

Author: Di SanteL, PaoloniM, DimaggioM, ColellaL, CerinoA, BernettiA, MurgiaM, SantilliV

Knee OA treatment

The group with the best performance for pain, functionality and dimension of BC was that in which combined use was made of horizontal and corticosteroid injection therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review.

Author: WangShi-Yi, Olson-KelloggBecky, ShamliyanTatyana A, ChoiJae-Young, RamakrishnanRema, KaneRobert L

Aerobic exercise improves disability
Aerobic exercise reduces pain
Strengthening exercise reduces pain
Ultrasonography reduces pain

Aerobic and aquatic exercise improved disability in patients with knee osteoarthritis. Aerobic exercise, strengthening exercise, and ultrasonography reduced pain and improved function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Doxycycline for osteoarthritis of the knee or hip.

Author: da CostaBruno R, NüeschEveline, ReichenbachStephan, JüniPeter, RutjesAnne W S

Osteoarthritis treatment

Doxycycline may slow cartilage degeneration and could be a disease-modifying agent for osteoarthritis. This updated review examines the evidence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.

Author: McAlindonTimothy, LaValleyMichael, SchneiderErica, NuiteMelynn, LeeJi Yeon, PriceLori Lyn, LoGrace, Dawson-HughesBess

Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

44.

Effectiveness of a cognitive-behavioral group intervention for knee osteoarthritis pain: protocol of a randomized controlled trial.

Author: HelminenEeva-Eerika, SinikallioSanna H, ValjakkaAnna L, Väisänen-RouvaliRauni H, ArokoskiJari P

Pain reduction

Knee osteoarthritis is a common condition causing pain. While biological factors are important, psychological aspects are also crucial. More research is needed to determine the effectiveness of psychological interventions for knee osteoarthritis pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

WITHDRAWN: Intensity of exercise for the treatment of osteoarthritis.

Author: BrosseauLucie, MacleayL, WelchVivian, TugwellPeter, WellsGeorge A

OA treatment
Limited data
More research needed

Both high intensity and low intensity aerobic exercise appear to be equally effective for improving functional status, gait, pain, and aerobic capacity for people with osteoarthritis of the knee.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis: a pilot trial.

Author: SchenckingMartin, WilmStefan, RedaelliMarcus

Mobility improvement
Pain reduction
Quality of life improvement

Osteoarthritis (OA) is becoming more common as the population ages. Kneipp hydrotherapy is a treatment for OA that involves using water to improve range of motion, reduce pain, and improve quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Studies of pain management in osteoarthritis: bedside to policy.

Author: LosinaE, DervanE E, DaigleM E, KatzJ N

OA pain management
Functional impairment
OA pain

This study characterizes studies examining the management of osteoarthritis (OA)-related pain with respect to interventions, trial duration, size, outcome measures, and funding sources.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

48.

Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition.

Author: JevsevarDavid S

Osteoarthritis treatment
Lack of research

This guideline, which updates a 2008 guideline, provides evidence-based recommendations for the treatment of osteoarthritis of the knee.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

An OA phenotype may obtain major benefit from bone-acting agents.

Author: Roman-BlasJorge A, CastañedaSantos, LargoRaquel, LemsWillem F, Herrero-BeaumontGabriel

Antiresorptive drugs
Osteoarthritis

Osteoarthritis (OA) involves changes in the structure of the bone under the cartilage, which is thought to contribute to the development of the disease. While treatments that slow down bone breakdown have been used for knee OA, results have been mixed, suggesting that some patients might benefit more than others from these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Exercise therapy may postpone total hip replacement surgery in patients with hip osteoarthritis: a long-term follow-up of a randomised trial.

Author: SvegeIda, NordslettenLars, FernandesLinda, RisbergMay Arna

Improved function
Reduced THR need
No pain/stiffness benefit

Exercise therapy, in addition to patient education, reduced the need for THR by 44% in patients with hip OA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

Conservative treatments, surgical treatments, and the KineSpring® Knee Implant system for knee osteoarthritis: a systematic review.

Author: LiChuan Silvia, AyeniOlufemi R, SpragueSheila, TruongVictoria, BhandariMohit

KineSpring Knee Implant

This review summarizes the results of studies evaluating treatments for knee osteoarthritis (OA) and compares them to a novel implantable load absorber called the KineSpring® Knee Implant System.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Evaluation of the effect of Lake Hévíz thermal mineral water in patients with osteoarthritis of the knee: a randomized, controlled, single-blind, follow-up study.

Author: KulischÁ, BenköÁ, BergmannA, GyarmatiN, HorváthHorváth, KrániczÁ, MándóZ S, MatánÁ, NémethA, SzakálE, SzántóD, SzekeresL, BenderT

Osteoarthritis treatment

Osteoarthritis is a common joint disease that causes pain and limited movement, especially in older adults. While treatments include non-medication, medication, and surgery, there is moderate evidence suggesting that balneotherapy (treatment using mineral-rich water) may be helpful.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

The effectiveness of autologous conditioned serum in the treatment of knee osteoarthritis.

Author: AstolfiMatthew, McGuireKelly, KaminskiThomas W

OA treatment

Osteoarthritis (OA) affects millions of Americans, and past knee injuries increase the risk of developing knee OA. While injections are often used to manage pain from OA, their effectiveness is limited, and relief is often short-lived. Corticosteroid injections provide more pain relief than hyaluronic acid (HA) injections in the short-term. A newer treatment called autologous conditioned serum (ACS) injection has shown promising results, but many doctors still use HA injections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Exercise therapy in hip osteoarthritis--a randomized controlled trial.

Author: KraußInga, SteinhilberBenjamin, HauptGeorg, MillerRegina, MartusPeter, JanßenPia

Hip OA function
Hip OA pain relief

This randomized controlled trial of 209 patients with hip osteoarthritis found that 12 weeks of exercise therapy reduced pain and improved physical function. No significant improvement was found in these patients' general health-related quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Do laterally wedged insoles or valgus braces unload the medial compartment of the knee in patients with osteoarthritis?

Author: DuivenvoordenTijs, van RaaijTom M, HoremansHerwin L D, BrouwerReinoud W, BosP Koen, Bierma-ZeinstraSita M A, VerhaarJan A N, ReijmanMax

Orthoses
Knee osteoarthritis

This research examines the use of orthoses for knee osteoarthritis (OA). While orthoses have shown potential biomechanical benefits, the study emphasizes the need for longitudinal research to evaluate their impact on clinical outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.

Author: BannuruRaveendhara R, SchmidChristopher H, KentDavid M, VaysbrotElizaveta E, WongJohn B, McAlindonTimothy E

Hyaluronic acid OA pain
IA treatments OA pain
Acetaminophen ineffective
IA corticosteroids not effective

This network meta-analysis found that intra-articular treatments were superior to nonsteroidal anti-inflammatory drugs for treating knee osteoarthritis (OA). Small but robust differences were observed between active treatments. All treatments except acetaminophen showed clinically significant improvement from baseline pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial.

Author: HenriksenMarius, ChristensenRobin, KlokkerLouise, BartholdyCecilie, BandakElisabeth, EllegaardKaren, BoesenMikael P, RiisRobert G Coumine, BartelsElse M, BliddalHenning

No additional benefit

An intra-articular injection of corticosteroid before exercise did not provide additional benefit for patients with painful osteoarthritis (OA) of the knee. Further research is needed to identify optimal and synergistic combinations of conservative treatments for OA of the knee.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial.

Author: KingsburySarah R, TharmanathanPuvan, ArdenNigel K, BatleyMichael, BirrellFraser, CocksKim, DohertyMichael, EdwardsChris J, GarroodToby, GraingerAndrew J, GreenMichael, HewittCatherine, HughesRod, MootsRobert, O'NeillTerence W, RoddyEdward, ScottDavid L, WattFiona E, TorgersonDavid J, ConaghanPhilip G

OA treatment

Osteoarthritis (OA) is a major cause of disability with limited treatment options. OA pain is often linked to inflammation of the joint lining (synovitis). Methotrexate (MTX) is a safe and effective treatment for synovitis in other inflammatory joint diseases like rheumatoid arthritis. This study proposes that MTX could be a practical and safe treatment for reducing synovitis and pain in patients with knee OA.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

59.

Small joints replacement for hand osteoarthritis: a systematic review.

Author: PapaliaRocco, TecameAndrea, TorreGugliemo, D'AdamioStefano, MaffulliNicola, DenaroVincenzo

Joint replacement
Osteoarthritis treatment

Silicone and pyrolitic carbon implants are effective for treating osteoarthritis of the hand, with silicone spacers being particularly effective for trapeziometacarpal osteoarthrosis and pyrolitic carbon total joint prostheses being effective for metacarpophalangeal replacement. However, complications such as persistent pain and implant loosening still occur at a variable rate. More and better designed studies are needed to determine the best implant for each joint type.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Current Concepts in the Management of Ankle Osteoarthritis: A Systematic Review.

Author: BlochBenjamin, SrinivasanSuresh, MangwaniJitendra

Arthrodesis
Arthroplasty designs
Joint-sparing surgery

Ankle osteoarthritis treatment options include analgesia, physiotherapy, injections, and surgical procedures like arthrodesis, joint-sparing surgery, and arthroplasty.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

The efficacy of non-surgical treatment on pain and sensitization in patients with knee osteoarthritis: a pre-defined ancillary analysis from a randomized controlled trial.

Author: SkouS T, RoosE M, SimonsenO, LaursenM B, RathleffM S, Arendt-NielsenL, RasmussenS

Reduced pain
Sensitization

This study compares a 3-month treatment program for knee osteoarthritis (OA) patients (MEDIC-treatment) to standard care in terms of reducing pain and sensitization. The MEDIC-treatment includes neuromuscular exercise, education, diet, insoles, and pain medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

Arthroscopic Debridement of the Knee: An Evidence Update.

Author:

Arthroscopic debridement ineffectiveness

This evidence update found no evidence to support the superiority of arthroscopic debridement with or without meniscectomy for patients with osteoarthritis of the knee or degenerative meniscal injury.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Hip arthroscopy in osteoarthritis: a systematic review of the literature.

Author: PiuzziNicolas S, SlullitelPablo A I, BertonaAgustin, OñativiaJosé I., AlbergoIgnacio, ZanottiGerardo, ButtaroMartin A, PiccalugaFrancisco, CombaFernando M

Improved function
Improved pain

Hip arthroscopy for osteoarthritis resulted in some improvement in pain and function in the short term, but the quality of studies was low.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle.

Author: WitteveenAngelique G H, HofstadCheriel J, KerkhoffsGino M M J

Improved function
Reduced pain

There is insufficient data to create a synthesis of the evidence for future guidelines for ankle osteoarthritis (OA). Simple analgesics are a reasonable first step to treat ankle OA, and HA can be conditionally recommended if patients have an inadequate response to simple analgesics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

AMSSM Scientific Statement Concerning Viscosupplementation Injections for Knee Osteoarthritis: Importance for Individual Patient Outcomes.

Author: TrojianThomas H, ConcoffAndrew L, JoySusan M, HatzenbuehlerJohn R, SaulsberryWhitney J, ColemanCraig I

Knee OA treatment

Osteoarthritis (OA) of the knee causes pain and limited mobility. While treatments include injections of hyaluronic acid (HA), steroids (IAS), and placebo (IAP), this review examines the effectiveness of these treatments based on how many patients achieve a meaningful improvement in function, as defined by specific criteria, rather than just comparing average changes between groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

66.

Intra-Articular Therapies in the Treatment of Hand Osteoarthritis: A Systematic Literature Review.

Author: KroonFéline P B, RubioRoxana, SchoonesJan W, KloppenburgMargreet

Ineffective treatment

This systematic review summarizes the benefits and harms of intra-articular (IA) therapies for treating hand osteoarthritis (OA). Meta-analysis of two trials comparing corticosteroids with placebo in carpometacarpal (CMC) OA showed no improvement in pain. HA also appeared ineffective compared to placebo in CMC OA. One trial comparing corticosteroids with placebo in interphalangeal (IP) OA showed significantly improved pain during movement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine.

Author: RichardsMasters M, MaxwellJoshua Shane, WengLihui, AngelosMathew G, GolzarianJafar

Knee OA treatment
Regenerative medicine

This review examines the evidence for intra-articular treatment of knee osteoarthritis (OA), including traditional treatments like injections and promising new regenerative medicine approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Aquatic exercise for the treatment of knee and hip osteoarthritis.

Author: BartelsElse Marie, JuhlCarsten B, ChristensenRobin, HagenKåre Birger, Danneskiold-SamsøeBente, DagfinrudHanne, LundHans

Aquatic exercise for osteoarthritis

This updated Cochrane review examines the effectiveness of aquatic exercise for managing osteoarthritis. Clinical trials suggest potential benefits of aquatic exercise for people with osteoarthritis, but more research is needed to confirm its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review.

Author: GayC, ChabaudA, GuilleyE, CoudeyreE

Function improvement
Pain reduction

Education, exercise, and weight loss are the pillars of non-pharmacological treatments for hip and knee osteoarthritis. These treatments have proven to be effective but require changes in patient behavior. Exercise and weight loss improve function and reduce pain. Education potentiates compliance to exercise and weight loss programs, thereby improving their long-term benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Effectiveness of Periosteal Stimulation Therapy and Home Exercise Program in the Rehabilitation of Patients With Advanced Knee Osteoarthritis.

Author: ElbadawyMohja A

Improved function

This study explored the potential of periosteal stimulation therapy (PST) with boosters, in combination with home exercises, as a treatment option for osteoarthritis (OA) of the knee.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

71.

A Comparison of Genicular Nerve Treatment Using Either Radiofrequency or Analgesic Block with Corticosteroid for Pain after a Total Knee Arthroplasty: A Double-Blind, Randomized Clinical Study.

Author: Qudsi-SinclairSalima, Borrás-RubioEnrique, Abellan-GuillénJuan F, Padilla Del ReyMaría Luz, Ruiz-MerinoGuadalupe

Knee OA treatment

Knee osteoarthritis affects about a third of people over 65 years old, causing pain and disability. Total knee replacement is the standard surgical treatment, but 15-30% of people who have this surgery continue to experience pain and limitations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

72.

Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis.

Author: RicciM, MicheloniG M, BertiM, PerusiF, SambugaroE, VecchiniE, MagnanB

OA treatment

Osteoarthritis (OA) is a progressive condition causing joint damage. Treatment typically focuses on managing symptoms using pain relievers and steroid injections. Hyaluronic acid (HA) injections into the joint may be helpful for early knee OA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

73.

Does preoperative physiotherapy improve postoperative, patient-based outcomes in older adults who have undergone total knee arthroplasty? A systematic review.

Author: CheshamRoss Alexander, ShanmugamSivaramkumar

Knee OA treatment

Knee osteoarthritis (OA) is a common problem for older adults in the UK, often leading to disability. When non-surgical treatments fail, knee replacement surgery is often the solution. Physical therapy before surgery is often recommended to improve outcomes after the procedure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Osteoarthritis year in review 2016: clinical.

Author: LaneN E, ShidaraK, WiseB L

OA treatment
OA progression

This systematic review examined recent literature on osteoarthritis (OA), focusing on both epidemiologic research identifying risk factors and clinical studies exploring treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Evaluation of the Effect of Hévíz Mud in Patients with Hand Osteoarthritis: A Randomized, Controlled, Single-Blind Follow-Up Study.

Author: GyarmatiNoémi, KulischÁgota, NémethAndrás, BergmannAnnamária, HorváthJózsef, MándóZsuzsanna, MatánÁgnes, SzakálErika, Sasné PéterTímea, SzántóDóra, BenderTamás

Improved hand osteoarthritis symptoms
Improved quality of life

Hévíz mud therapy significantly improved hand osteoarthritis symptoms and quality of life in patients. Patients who had the mud applied directly to their hands had a greater improvement in pain, stiffness, and swollen joint count than those who used mud with a nylon glove barrier.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

76.

[TREATMENT FOR OSTEOARTHRITIS OF THE KNEE].

Author: GiwnewerUriel, RubinGuy, OrbachHagay, RozenNimrod

Osteoarthritis is a common joint disorder, especially affecting the knee, and is becoming more prevalent. Diagnosis can be difficult due to a lack of specific signs. Treatment aims to reduce pain, address joint misalignment, and improve stability. This review summarizes the American Academy of Orthopedic Surgeons (AAOS) guidelines for managing knee osteoarthritis, which focus on non-surgical approaches to manage pain and function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Hebrew

77.

Celecoxib for osteoarthritis.

Author: PuljakLivia, MarinAna, VrdoljakDavorka, MarkoticFilipa, UtrobicicAna, TugwellPeter

OA treatment

Osteoarthritis (OA) is a common joint condition that causes pain and limited movement. There is no single best treatment for OA. Celecoxib is a type of pain reliever that is specifically designed to reduce inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

The Effectiveness of Manual Therapy for Relieving Pain, Stiffness, and Dysfunction in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.

Author: XuQinguang, ChenBei, WangYueyi, WangXuezong, HanDapeng, DingDaofang, ZhengYuxin, CaoYuelong, ZhanHongsheng, ZhouYao

Improved KOA function
Reduced KOA pain
Reduced KOA stiffness

Manual therapy may be effective and safe for improving pain, stiffness, and physical function in knee osteoarthritis (KOA) patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Effect of weight losing on the clinical status improvement of patients with knee osteoarthritis.

Author: SadeghiAlireza, RadZahra Abbaspour, SajediBehnam, HeydariAmir Hossein, AkbariehSamira, JafariBehzad

Knee osteoarthritis treatment

Osteoarthritis (OA) is a common condition causing pain and disability, especially in the knee. While there are treatments to manage OA symptoms, none are a cure. This study examines the potential of weight loss as a long-term and effective treatment for knee OA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

82.

Dose-Response Effects of Tai Chi and Physical Therapy Exercise Interventions in Symptomatic Knee Osteoarthritis.

Author: LeeAugustine C, HarveyWilliam F, PriceLori Lyn, HanXingyi, DribanJeffrey B, IversenMaura D, DesaiSima A, KnoppHans E, WangChenchen

Function improvement
Pain reduction

Tai Chi and physical therapy exercise for knee osteoarthritis showed dose-dependent effects on pain and function, with minimum effective doses ranging from 2-5 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

83.

Effectiveness of Valgus Offloading Knee Braces in the Treatment of Medial Compartment Knee Osteoarthritis: A Systematic Review.

Author: GohalChetan, ShanmugarajAjaykumar, TatePatrick, HornerNolan S, BediAsheesh, AdiliAnthony, KhanMoin

Knee osteoarthritis treatment
Nonoperative modalities
Total knee arthroplasties

Knee osteoarthritis affects millions of people in the US, causing significant disability. While knee replacement surgery is becoming more common, the potential complications and costs associated with it make exploring non-surgical treatments like knee braces crucial for managing the condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Mixed Treatment Comparisons for Nonsurgical Treatment of Knee Osteoarthritis: A Network Meta-analysis.

Author: JevsevarDavid S, ShoresPeter B, MullenKyle, SchulteDanielle M, BrownGregory A, CumminsDeborah S

Improved function
Improved pain

Naproxen is the most effective individual treatment for pain and function in patients with knee osteoarthritis (KOA). Naproxen and IA corticosteroids are the most probable to improve pain and function when combined.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

85.

Efficacy of a Community-Based Technology-Enabled Physical Activity Counseling Program for People With Knee Osteoarthritis: Proof-of-Concept Study.

Author: LiLinda C, SayreEric C, XieHui, FalckRyan S, BestJohn R, Liu-AmbroseTeresa, GrewalNavi, HoensAlison M, NoonanGreg, FeehanLynne M

Improved activity
Improved quality of life

This randomized controlled trial evaluated the efficacy of a technology-enabled counseling intervention for improving physical activity in people with knee osteoarthritis. Participants who received immediate counseling showed significant improvements in moderate-to-vigorous physical activity, daily steps, and quality of life. These findings suggest that technology-enabled counseling can effectively promote physical activity and improve health outcomes in people with knee osteoarthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

86.

Alternatives to Biologics in Management of Knee Osteoarthritis: A Systematic Review.

Author: HassanFadi, MurrellWilliam D, RefaloAndrew, MaffulliNicola

Improved function
Improved pain
Long-term benefit
Short-term benefit

This review analyzed the evidence for non-biological treatments for knee osteoarthritis (KOA). Moderate supportive evidence exists for the effectiveness of prolotherapy in improving pain and function. Limited supporting evidence was found for botulinum toxin type A, sodium bicarbonate, calcium gluconate, and low-molecular weight fraction of human serum albumin. Evidence for local anesthetic agents was conflicting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Does frontal knee kinematics predict treatment outcomes? Exploratory analyses from the Intensive Diet and Exercise for Arthritis (IDEA) trial.

Author: HallMichelle, BennellKim L, BeaversDaniel P, WrigleyTim V, DeVitaPaul, MessierStephen P

Reduced knee pain

Knee pain is a common symptom of knee osteoarthritis (OA). While exercise and diet can reduce pain, their effects are modest. Frontal plane knee joint motion appears to be a patient-specific characteristic that could be used to personalize interventions and improve pain reduction for OA patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

88.

Function scores of different surgeries in the treatment of knee osteoarthritis: A PRISMA-compliant systematic review and network-meta analysis.

Author: LiuCheng-Yao, LiChuan-Dong, WangLiang, RenShan, YuFu-Bin, LiJin-Guang, MaJiang-Xiong, MaXing-Long

Improved function

Osteotomy and unicompartmental knee arthroplasty showed better short-term efficacy in improving function scores in patients with knee osteoarthritis, while total knee arthroplasty appeared to have better long-term efficacy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Cost Effectiveness of Intra-Articular Hyaluronic Acid and Disease-Modifying Drugs in Knee Osteoarthritis.

Author: SalmonJean-Hugues, RatAnne-Christine, Charlot-LambrechtIsabelle, EschardJean-Paul, JollyDamien, FautrelBruno

Symptomatic efficacy for knee OA
Heterogeneous cost-effectiveness estimates
No efficacy for disease modification

The cost-effectiveness of disease-modifying osteoarthritis drugs and intra-articular hyaluronic acid for knee osteoarthritis is uncertain, with incremental cost-effectiveness ratios ranging from cost savings to very high values.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Efficacy of commonly prescribed analgesics in the management of osteoarthritis: a systematic review and meta-analysis.

Author: StewartMohan, CibereJolanda, SayreEric C, KopecJacek A

Pain reduction

Acetaminophen was found to have an effect on pain reduction in osteoarthritis (OA) similar to oral NSAIDs. Oral NSAIDs, COX-2 inhibitors, and opioids showed similar effects to previous literature. Topical NSAIDs were found to have a greater effect than oral NSAIDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Efficacy of self-management exercise program with spa therapy for behavioral management of knee osteoarthritis: research protocol for a quasi-randomized controlled trial (GEET one).

Author: GayChloe, Guiguet-AuclairCandy, PereiraBruno, GoldsteinAnna, BareyreLoïc, CosteNicolas, CoudeyreEmmanuel

Improved OA treatment

This study highlighted the importance of increasing physical activity (PA) levels to manage osteoarthritis (OA) and reduce associated risk factors, considering the condition's impact beyond joint pain and stiffness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

92.

Efficacy and Safety of Massage for Osteoarthritis of the Knee: a Randomized Clinical Trial.

Author: PerlmanAdam, FogeriteSusan Gould, GlassOliver, BechardElizabeth, AliAther, NjikeValentine Y, PieperCarl, DmitrievaNatalia O, LucianoAlison, RosenbergerLisa, KeeverTeresa, MilakCarl, FinkelsteinEric A, MahonGwendolyn, CampanileGiovanni, CotterAnn, KatzDavid L

Improved osteoarthritis
Safe massage
Short-term relief

Weekly massage for 8 weeks significantly improved WOMAC Global scores in patients with knee osteoarthritis compared to light-touch or usual care. Biweekly massage maintained improvements but did not provide additional benefit beyond usual care after 8 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

93.

Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study.

Author: HuangYong, LiuXiaolu, XuXinliang, LiuJunbin

CS
HA
IA therapies
KOA treatment
PRP

Knee osteoarthritis (KOA) is a painful condition with no cure. While there are various treatments for KOA, injections into the joint (intra-articular therapies) are increasingly used, including platelet-rich plasma (PRP), hyaluronic acid (HA), and corticosteroids (CS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

94.

The Effect of Prehabilitation on Postoperative Outcome in Patients Following Primary Total Knee Arthroplasty.

Author: JahicDzenan, OmerovicDjemil, TanovicAdnana Talic, DzankovicFuad, CamparaMerita Tiric

Preoperative exercise
TKA treatment

This study investigates the effectiveness of pre-operative exercise (prehabilitation) for patients undergoing total knee replacement surgery (TKA). While knee replacement is a common and effective treatment for severe osteoarthritis (OA), the role of pre-surgery exercise is still debated. The study aims to determine if prehabilitation improves outcomes for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

95.

The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis.

Author: StrathLarissa J, JonesCatherine D, Philip GeorgeAlan, LukensShannon L, MorrisonShannon A, SoleymaniTaraneh, LocherJulie L, GowerBarbara A, SorgeRobert E

Dietary intervention
Knee osteoarthritis treatment

A dietary intervention may be a promising alternative treatment option for knee osteoarthritis (KOA) to reduce pain. While there are currently no cures for KOA, this intervention has the potential to offer relief for patients who experience persistent pain from this condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

96.

Analgesic Herbal Medicines in the Treatment of Knee Osteoarthritis: A Systematic Review.

Author: TeymouriSoudeh, RakhshandehHasan, BaghdarHamideh Naghedi, YousefiMahdi, SalariRoshanak

CAM
Knee OA treatment
Side effects of chemical medications

Osteoarthritis (OA) is a common joint disease that can cause significant pain and disability. While there are various treatments available, including medication and surgery, these options often have side effects. Due to the chronic nature of OA and potential side effects of conventional treatments, people are increasingly turning to complementary and alternative medicine (CAM) as a potential solution.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee.

Author: CharlesworthJonathon, FitzpatrickJane, PereraNirmala Kanthi Panagodage, OrchardJohn

Improved treatment options
Long-term safety assessment

This systematic review evaluates the long-term safety of common treatments for knee osteoarthritis (KOA). The study finds that most common treatments provide only short-term symptom relief and that long-term safety is not well-established.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.

Author: HonvoGermain, ReginsterJean-Yves, RabendaVéronique, GeerinckAnton, MkinsiOuafa, CharlesAlexia, RizzoliRene, CooperCyrus, AvouacBernard, BruyèreOlivier

OA treatment

GS and CS can be considered safe treatments for patients with OA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

Weight loss exclusively through diet for knee osteoarthritis.

Author: RíosClemente, IrarrázavalSebastián

Improved knee osteoarthritis treatment

This study discussed the potential of diet as a treatment option for knee osteoarthritis, considering its role in weight loss and symptom improvement, acknowledging the need for further research to assess its effectiveness as a sole intervention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Spanish

100.

Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial.

Author: SchnitzerThomas J, EastonRichard, PangShirley, LevinsonDennis J, PixtonGlenn, ViktrupLars, DavignonIsabelle, BrownMark T, WestChristine R, VerburgKenneth M

Pain and function improvement
Joint replacements
Joint safety events

Tanezumab, compared with placebo, resulted in statistically significant improvements in scores assessing pain and physical function in patients with moderate to severe osteoarthritis of the knee or hip, with modest improvements in patient global assessment of osteoarthritis. However, tanezumab-treated patients had more joint safety events and total joint replacements.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

101.

Effectiveness of Denervation Therapy on Pain and Joint Function for Patients with Refractory Knee Osteoarthritis: A Systematic Review and Meta-Analysis.

Author: WangRan, MaChao, HanYing, TanMengjiao, LuLijuan

Alternative treatment
Controversial efficacy

The therapeutic effect of denervation therapy for intractable osteoarthritis (OA), especially the long-term efficacy, is still controversial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

102.

The effectiveness of foot orthoses in the treatment of medial knee osteoarthritis: A systematic review.

Author: ZafarAbdal Qadir, ZamaniReza, AkramiMohammad

Improved knee osteoarthritis treatment

This study explores the effective characteristics of different insoles and footwear for treating knee osteoarthritis, which is a condition affecting joint function and causing pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Outcomes of a conservative care program for knee osteoarthritis through translation of research into practice.

Author: RossAndrew, GasconGregg M, SnowRichard, SawchynGreg, DeRoadsKristin, RuaneJoseph J

Functional improvement
Knee osteoarthritis management

This study discusses the underutilization of conservative treatment approaches for knee osteoarthritis, despite evidence-based guidelines recommending a non-surgical approach as first-line treatment. The study aims to observe meaningful functional improvement in a specific population by applying organized conservative components of care in an evidence-based management program.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

104.

Cooled radiofrequency ablation provides extended clinical utility in the management of knee osteoarthritis: 12-month results from a prospective, multi-center, randomized, cross-over trial comparing cooled radiofrequency ablation to a single hyaluronic acid injection.

Author: ChenAntonia F, KhaloufFred, ZoraKeith, DePalmaMichael, KohanLynn, GuirguisMaged, BeallDouglas, LoudermilkEric, PingreeMatthew J, BadiolaIgnacio, LymanJeffrey

Improved quality of life
Sustained pain relief

Cooled radiofrequency ablation (CRFA) provided sustained knee pain relief for at least 12 months in patients with knee osteoarthritis (OA). CRFA was also effective for patients who crossed over from hyaluronic acid (HA) treatment after 6 months.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

105.

Comparative efficacy of treatments for patients with knee osteoarthritis: a network meta-analysis.

Author: LiBingtong, ZhangYuzheng, BiLiqi

Improved knee osteoarthritis treatment

This network meta-analysis aims to assess the efficacy and safety of treatments for knee osteoarthritis, providing more comprehensive medical evidence.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

107.

Collaborative model of care between Orthopaedics and allied healthcare professionals trial (CONNACT) - a feasibility study in patients with knee osteoarthritis using a mixed method approach.

Author: TanBryan Yijia, DingBenjamin Tze Keong, PereiraMichelle Jessica, SkouSoren Thorgaard, ThumbooJulian, CarJosip

Improved knee osteoarthritis
Osteoarthritis treatment

This study proposes a new model of care for knee osteoarthritis that utilizes a multidisciplinary approach and individualized interventions to improve behavior change and overall effectiveness of treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

108.

Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon.

Author: BeaudartC, LengeléL, LeclercqV, GeerinckA, Sanchez-RodriguezD, BruyèreO, ReginsterJ Y

Improved function
OA pain relief
OA progression

This network meta-analysis (NMA) assesses the efficacy of various drugs prescribed for knee osteoarthritis (OA) in terms of pain and function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

Efficacy of an exercise program combined with lifestyle education in patients with knee osteoarthritis.

Author: AlfieriFábio Marcon, LimaAlessandra Rodrigues Souto, SalgueiroMarcia Maria Hernandes de Abreu de Oliveira, AndradeElisabete Agrela de, BattistellaLinamara Rizzo, SilvaNatália Cristina de Oliveira Vargas E

Improved lifestyle
Pain relief
No improvement in functionality

An exercise program with lifestyle education is more effective in reducing pain in individuals with knee osteoarthritis (OA) compared to an exercise program alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

110.

Corticosteroids: Review of the History, the Effectiveness, and Adverse Effects in the Treatment of Joint Pain.

Author: StoneShane, MalangaGerard A, CapellaTeresa

Improved function
Reduced pain
Cartilage toxicity
Increased blood glucose
Increased infections
Reduced immune function

This narrative review summarized the research on corticosteroids for joint pain from its initial discovery to the present day. The study found that corticosteroids provide moderate short-term benefit for reducing pain and improving function, but these benefits generally last several weeks without long-term effectiveness. The study also highlighted potential adverse effects including toxicity to articular cartilage and numerous systemic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

111.

Effects of additional action observation to an exercise program in patients with chronic pain due to knee osteoarthritis: A randomized-controlled trial.

Author: ÖztürkÖzgül, BombacıHasan, KeçeciTolga, AlgunZeliha Candan

Functional improvement
Pain relief

This study found that action observation therapy, added to an exercise program, did not provide any additional benefit for pain severity, pressure pain threshold, kinesiphobia, pain catastrophization, or functionality in knee osteoarthritis patients with chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

112.

Effectiveness of Internet-Based Exercises Aimed at Treating Knee Osteoarthritis: The iBEAT-OA Randomized Clinical Trial.

Author: GohirSameer Akram, EekFrida, KellyAnthony, AbhishekAbhishek, ValdesAna M

Improved function
Reduced pain

This randomized clinical trial compared an internet-based treatment for knee osteoarthritis to routine self-management. The internet-based treatment group showed significant improvements in pain, physical functioning, and overall osteoarthritis symptoms compared to the control group. These findings suggest that internet-based treatment is an effective and safe option for managing knee osteoarthritis and could contribute to improving access to first-line treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

113.

Efficacy of intra-articular corticosteroid injections in knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

Author: NajmAurélie, AlunnoAlessia, GwinnuttJames M, WeillCatherine, BerenbaumFrancis

Function improvement
Pain reduction

IA GC injections reduced pain and improved function early after administration compared to placebo. Other interventions seem to be more efficient in the long term, but this effect was largely driven by single studies with large effect sizes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

114.

Chinese Herbal Fumigation Steam Therapy and Acupuncture in the Treatment of Knee Osteoarthritis: A Three-armed, Randomized, Controlled Trial.

Author: VenutiAnthony J, ChiuJung-Peng, YuKai-Chiang, ChangShang-Chih, LinShu-Yi, HsuChung-Hua

KOA treatment

Knee osteoarthritis (KOA) is a common and disabling condition, affecting daily activities more than any other disease. Despite its prevalence, there is no single, effective treatment for KOA.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

115.

Relative Efficacy of Intra-articular Injections in the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-analysis.

Author: SinghHarsh, KnapikDerrick M, PolceEvan M, EikaniCarlo K, BjornstadAmanda H, GursoySafa, PerryAllison K, WestrickJennifer C, YankeAdam B, VermaNikhil N, ColeBrian J, ChahlaJorge A

Improved knee OA

This meta-analysis compared the efficacy of intra-articular injections for knee osteoarthritis. Platelet-rich plasma (PRP) showed the highest probability of efficacy compared to hyaluronic acid, corticosteroids, plasma rich in growth factors, and placebo at a minimum 6-month follow-up.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

116.

AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition.

Author: BrophyRobert H, FillinghamYale A

Nonarthroplasty treatment for osteoarthritis of the knee

This clinical practice guideline provided recommendations for the nonarthroplasty treatment of osteoarthritis of the knee, emphasizing the need for more research on specific interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

117.

Injection of biologic agents for treating severe knee osteoarthritis: is there a chance for a good outcome? A systematic review of clinical evidence.

Author: AnzillottiG, ConteP, Di MatteoB, BertolinoE M, MarcacciM, KonE

OA treatment

Osteoarthritis (OA) is a common joint disease, and knee OA is the most prevalent type. This study analyzed the rationale for using injectable ortho-biological treatments, such as platelet-rich plasma (PRP) and mesenchymal cells, in patients with severe knee OA. The study suggests that injectable ortho-biological treatments may be a promising option for patients with severe knee OA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Systematic Review and Network Meta-analysis of Acupuncture Combined with Massage in Treating Knee Osteoarthritis.

Author: WangZhen, WangYongquan, WangCongan, LiXujie, ZhouZiyang, ZhangLijuan, LiMiaoxiu, PanYankun, JiaoTiyong, ShiXiaoyun, LiuQing

Acupuncture and massage benefits
KOA treatment

This systematic review and meta-analysis evaluated the efficacy and safety of acupuncture and massage combined with treatment for knee osteoarthritis (KOA). The study found that acupuncture combined with massage could improve the clinical therapeutic effect of patients with KOA. The most effective interventions included floating needle+massage, needle knife+massage, and silver needle+massage. Further research is needed to validate these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

119.

Does a home-based exercise program play any role in the treatment of knee osteoarthritis? A meta-analysis.

Author: WangJibing, XieDongfeng, CaiZhijun, LuoMeimei, ChenBo, SunYuguang, LiuHuixia

HBE benefits
KOA treatment

This meta-analysis assessed the role of home-based exercise (HBE) programs in the treatment of knee osteoarthritis. The study found that HBEs were associated with a reduction in WOMAC scores and improved clinical symptoms. The findings suggest that HBEs may be an effective and safe treatment option for knee osteoarthritis.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

120.

Development of a prediction model to determine responders to conservative treatment in people with symptomatic hand osteoarthritis: A secondary analysis of a single-centre, randomised feasibility trial.

Author: MagniN, RiceD, McNairP

Predictive tool for response

This study developed a prediction tool to identify individuals with hand osteoarthritis who are likely to respond to conservative treatment. The basic model, which included treatment type, expectations, and adherence, had acceptable discrimination and calibration.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

121.

Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials.

Author: WengQianlin, GohSiew-Li, WuJing, PerssonMonica S M, WeiJie, SarmanovaAliya, LiXiaoxiao, HallMichelle, DohertyMichael, JiangTing, ZengChao, LeiGuanghua, ZhangWeiya

Functional improvement
Pain relief

This network meta-analysis compared exercise therapy with oral non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol for knee or hip osteoarthritis (OA). Exercise was found to have similar effects on pain and function compared to NSAIDs and paracetamol. Given its excellent safety profile, the authors recommend emphasizing exercise in clinical care for OA, particularly for older individuals at risk for adverse events from NSAIDs and paracetamol.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

122.

Stretching, Bracing, and Devices for the Treatment of Osteoarthritis-Associated Joint Contractures in Nonoperated Joints: A Systematic Review and Meta-Analysis.

Author: CampbellT Mark, WestbyMarie, GhogomuElizabeth Tanjong, FournierJohn, GhaediBahareh Bahram, WelchVivian

Improved knee ROM
Reduced pain
None reported

This meta-analysis of 9 randomized controlled trials found moderate-quality evidence that stretching is an effective treatment for knee osteoarthritis, improving total, flexion, and extension range of motion (ROM) and reducing pain. The average improvement in total ROM was 9.3 degrees, knee flexion ROM was 10.8 degrees, and knee extension ROM was 9.1 degrees. There were no reported adverse events.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

123.

Do imaging findings modify the effect of non-surgical treatment in patients with knee and hip osteoarthritis? A systematic literature review.

Author: ClausenStine, HeereyJoshua, HartvigsenJan, KempJoanne L, ArnbakBodil

Hip OA
Knee OA

This review of eight studies found that the effect of non-surgical interventions for knee and hip osteoarthritis (OA) may vary depending on the severity of the condition. One study found that those with more severe radiographic knee OA had a greater response to unloading shoes, while another study found no difference in response to intra-articular injections of corticosteroid or hyaluronic acid in hip OA based on radiographic OA severity or joint effusion.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

124.

A comparative study of the efficacy of intra-articular injection of different drugs in the treatment of mild to moderate knee osteoarthritis: A network meta-analysis.

Author: XueYuan, WangXuan, WangXiuming, HuangLi, YaoAina, XueYan

KOA treatment

This study examined the efficacy of intra-articular (IA) injection for treating knee osteoarthritis (KOA), considering the potential benefits and ongoing debates regarding its effectiveness.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

125.

Observation of the therapeutic effect of auricular bean pressing on early knee osteoarthritis pain: A randomized controlled trial.

Author: LinYeyan, WuYongqin, ZhouXuelai, ShenBin, LvCunxian

KOA pain relief
Knee function

Auricular bean-pressing therapy effectively reduced pain, swelling, and stiffness in patients with early KOA, improving knee function and quality of life.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

126.

Exercise Plus Acupuncture on Consensus Acupoints Versus Acupoints Selected by the Theory of Equal Impact on Tendons, Bones, and Muscles for Knee Osteoarthritis.

Author: YangJiaxiang, LanXiangdong, CaiQingcheng, LuZiheng, WangYanjun

KOA treatment

This study explores the effectiveness of acupuncture and exercise for treating knee osteoarthritis (KOA). While acupuncture is a popular treatment, its effectiveness compared to exercise alone is debated.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

127.

Interleukins, growth factors, and transcription factors are key targets for gene therapy in osteoarthritis: A scoping review.

Author: UebelhoerMelanie, LambertCécile, GrisartJuliane, GuseKilian, PlutizkiStanislav, HenrotinYves

Gene therapy for OA

This scoping review examines preclinical and clinical studies reporting the effect of gene therapies for osteoarthritis (OA).

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

128.

Highlighting the Advantages and Benefits of Non-NSAID Treatment After Total Knee Arthroplasty: A Cross-sectional Study.

Author: MurvaiGelu Florin, HozanCalin Tudor, MagheruCalin, SzilagyiGheorghe, BulzanMadalin, MurvaiViorela Romina, CavaluSimona, GhiteaTimea Claudia

Improved postoperative outcomes

This study highlights disparities in postoperative outcomes between knee arthroplasty procedures with and without non-steroidal anti-inflammatory drugs (NSAIDs), focusing on the immediate advantages and outcomes observed at the 6-month milestone.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

129.

OARSI year in review 2023: Rehabilitation and outcomes.

Author: MacriE M, SellesR W, StefanikJ J, ReijmanM

OA treatment

This study examined research published between March 2022 and March 2023 that compared different treatments for osteoarthritis (OA). The review focused on studies comparing core treatments like exercise, education, and weight management; additional treatments like electrical stimulation and braces; and combinations of different treatments.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

130.

[Functionality/isokinetic work of quadriceps in patients with gonarthrosis managed with prolotherapy].

Author: Martínez-BarroDaniel, Rivera-BelloJoel Dair, Cruz-LópezJannet Mercedes, Hernández-AmaroHermelinda, Rojano-MejíaDavid

Functionality improvement
Knee osteoarthritis treatment

Prolotherapy and saline infiltration both increased functionality, strength, and decreased pain in patients with knee osteoarthritis. However, there was no significant difference between the two groups.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

131.

Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: a systematic review and network meta-analysis.

Author: QiaoXiaochen, YanLei, FengYi, LiXiaoyan, ZhangKun, LvZhi, XuChaojian, ZhaoSen, LiuFengrui, YangXihua, TianZhi

KOA treatment
PRP efficacy

A network meta-analysis of 35 studies involving 3104 participants with knee osteoarthritis (KOA) found that platelet-rich plasma (PRP) and PRP combined with hyaluronic acid (HA) were the most effective treatments in improving function and reducing pain at 3, 6, and 12 months. No significant increase in treatment-related adverse events was observed with any of the therapies compared to placebo.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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