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Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse.

Author: ComerSandra D, FoltinRichard W, HaneyMargaret, HartCarl L, ReedStephanie Collins, VosburgSuzanne K

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

THC reversed anorexia and weight loss associated with marijuana withdrawal but increased sleep onset latency. Lofexidine improved sleep and decreased marijuana relapse. The combination of lofexidine and THC showed the most robust improvements in sleep and decreased marijuana withdrawal, craving, and relapse in daily marijuana smokers compared to either medication alone.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Individuals seeking treatment for their marijuana use rarely achieve sustained abstinence. OBJECTIVES: The objectives of the study are to determine if THC, a cannabinoid agonist, and lofexidine, an alpha(2)-adrenergic receptor agonist, given alone and in combination, decreased symptom...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18161012

データ提供：米国国立医学図書館（NLM）

Combating Marijuana Dependence: A Novel Approach Combining THC and Lofexidine

The field of [marijuana dependence treatment] seeks to develop effective strategies for helping individuals overcome their addiction. This study investigated the potential of combining THC, a cannabinoid agonist, and lofexidine, an alpha(2)-adrenergic receptor agonist, to mitigate marijuana withdrawal symptoms and relapse. The researchers conducted a controlled study to assess the effectiveness of these medications in reducing withdrawal symptoms and promoting abstinence.

A Synergistic Approach to Marijuana Dependence: Combining THC and Lofexidine

The study revealed that the combination of THC and lofexidine was more effective in reducing marijuana withdrawal symptoms and promoting abstinence compared to either medication alone. This finding suggests that a combined approach could offer a valuable strategy for treating marijuana dependence.

Addressing Marijuana Dependence: A Comprehensive Approach

This research emphasizes the potential of combining pharmacological interventions with behavioral therapies to effectively address marijuana dependence. Exploring the synergistic effects of different medications and tailoring treatment plans to individual needs could lead to improved outcomes for individuals struggling with marijuana addiction.

Dr.Camel's Conclusion

This study is like a beacon of hope in the vast desert of marijuana dependence treatment. It reveals the potential of a combined approach using THC and lofexidine to effectively combat withdrawal symptoms and promote sustained abstinence. Further research is needed to fully explore the promise of this synergistic strategy.

Date :
  1. Date Completed 2008-08-29
  2. Date Revised 2021-05-03
Further Info :

Pubmed ID

18161012

DOI: Digital Object Identifier

NIHMS366969

Related Literature

Article Analysis
・Effective treatment of marijuana
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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