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Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving.

Author: AraiHiroyuki, HorikawaEtsuo, ItohMasatoshi, MaruyamaMasahiro, MochizukiHideki, OkamuraNobuyuki, SakuradaYumiko, TashiroManabu, WatanukiShoichi, YanaiKazuhiko

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined regional cerebral blood flow (rCBF) responses during a simulated car-driving task following oral administration of D-chlorpheniramine using positron emission tomography (PET) and [15O]H2O. This research aimed to elucidate the mechanism underlying the sedative side effects of antihistamines, which are potentially dangerous in car driving.
Paper Details　
Original Abstract of the Article :
The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car...See full text at original site
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引用元：
https://doi.org/10.1002/hup.909

データ提供：米国国立医学図書館（NLM）

Antihistamines and Driving: A Journey Through Regional Cerebral Perfusion

The desert of driving safety is vast and complex, and understanding the effects of medications on driving ability is crucial. This study explores the impact of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving. The authors used positron emission tomography (PET) to examine brain activity in participants after administering D-chlorpheniramine, revealing a significant reduction in regional cerebral blood flow (rCBF) in brain areas associated with driving performance. The findings suggest that D-chlorpheniramine may impair driving ability due to its sedative effects on brain function.

A Cautionary Tale: Antihistamines and Driving Performance

This research highlights the potential dangers of driving under the influence of sedative antihistamines. The study's findings suggest that D-chlorpheniramine can significantly impair driving performance by reducing blood flow to brain regions crucial for driving skills.

Driving Safety: Making Informed Choices

This study underscores the importance of making informed choices about medication and driving. The findings suggest that individuals taking sedative antihistamines should avoid driving or engaging in other activities that require alertness and cognitive function.

Dr. Camel's Conclusion

This study offers a valuable exploration of the effects of D-chlorpheniramine on regional cerebral perfusion and driving performance. The findings suggest that this sedative antihistamine can significantly impair driving ability by reducing blood flow to crucial brain regions. This research highlights the importance of making informed choices about medication and driving, prioritizing safety and avoiding driving while taking medications that can impair alertness and cognitive function.

Date :
  1. Date Completed 2008-03-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18181241

DOI: Digital Object Identifier

10.1002/hup.909

SNS
PICO Info
in preparation
Languages

English

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