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Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions.
Author: HirotaHiroshi, MatsuoYo, MinaiRyoichi, OnukiHiroyuki
Original Abstract of the Article :
Many drugs, even ones that are designed to act selectively on a target protein, bind unintended proteins. These unintended bindings can explain side effects or indicate additional mechanisms for a drug's medicinal properties. Structural similarity between binding sites is one of the reasons for bind...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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引用元:
https://doi.org/10.1002/prot.21933
データ提供:米国国立医学図書館(NLM)
The Desert of Drug Targets: Mapping Protein-Drug Interactions
Drugs, like travelers seeking their destination, often interact with multiple proteins in the body. This research, like a map through a vast and intricate desert, explores the complex landscape of protein-drug interactions. Researchers, like skilled cartographers, delve into the similarities and differences between protein ligand-binding sites, revealing the intricate pathways by which drugs bind to their targets. They employ a novel method for structural alignment, akin to using a compass to navigate the desert, to analyze the relationships between structural similarity and drug-target interactions. Their findings, like shimmering oases discovered after a long journey, provide valuable insights into the complexities of protein-drug interactions and their implications for drug development.Navigating the Desert of Protein-Drug Interactions: A New Compass for Drug Development
The study, like a camel traversing a desert landscape, reveals the importance of understanding protein-drug interactions for drug development. Researchers, like explorers charting new territory, highlight the potential for unintended binding events, which can lead to side effects or reveal additional mechanisms of action. This research, like a beacon illuminating the path ahead, provides a valuable tool for predicting protein-drug interactions, paving the way for safer and more effective drug therapies.A Journey Through the Desert of Drug Development: Understanding the Landscape
The study, like a guidebook for travelers venturing into the desert, provides insights into the complexities of protein-drug interactions. It emphasizes the importance of understanding these interactions, not only for predicting drug efficacy but also for anticipating potential side effects. This research, like a well-worn path through the desert, offers a roadmap for drug development, guiding researchers toward safer and more targeted therapies.Dr. Camel's Conclusion
This research, like a camel navigating a desert of knowledge, explores the intricate landscape of protein-drug interactions. It highlights the importance of understanding these interactions for developing safe and effective drugs. The findings, like shimmering oases in the distance, provide valuable insights for researchers seeking to improve drug development and enhance patient care. Just as a skilled desert explorer relies on a combination of knowledge, skills, and tools, so too must drug developers navigate this complex terrain.Date :
- Date Completed 2008-07-21
- Date Revised 2008-06-03
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