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Long versus short course treatment with Metformin and Clomiphene Citrate for ovulation induction in women with PCOS.

Author: BuppasiriP, LumbiganonP, PattanittumP, SinawatS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Polycystic ovary syndrome (PCOS) is the most common hormonal disorder in women of reproductive age. Besides infertility, women with PCOS often have other hormonal problems, including insulin resistance, high insulin levels, and high levels of male hormones. Metformin, when combined with clomiphene citrate, has been shown to be more effective in inducing ovulation than clomiphene alone. However, the ideal length of time to take metformin before starting clomiphene is unknown.
Paper Details　
Original Abstract of the Article :
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive-aged women. Apart from infertility, women with PCOS often have other endocrine disorders, including insulin resistance,hyperinsulinaemia and hyperandrogenism. Metformin,combined with clomiphene citrate (CC), has be...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD006226.pub2

データ提供：米国国立医学図書館（NLM）

Optimizing Metformin and Clomiphene Citrate Treatment for PCOS

This research delves into the complex world of polycystic ovary syndrome (PCOS), a hormonal disorder affecting millions of women. It examines the effectiveness of combining metformin with clomiphene citrate (CC) for ovulation induction, a common treatment for infertility in women with PCOS. The study explores the optimal duration of metformin pretreatment before initiating CC, aiming to improve treatment outcomes. It's like finding the perfect balance in a desert recipe: we need to carefully adjust the ingredients and timing to achieve the desired outcome.

Metformin and Clomiphene Citrate: A Powerful Combination for PCOS

The study found that combining metformin with CC for ovulation induction was more effective than using CC alone. However, the optimal duration of metformin pretreatment remains unclear. The study suggests that further research is needed to determine the optimal duration of metformin treatment for individual patients. It's like finding the perfect oasis in a vast desert: we need to explore different pathways and strategies to optimize treatment outcomes for women with PCOS.

Improving Fertility Outcomes for Women with PCOS: A Continuous Journey

The study highlights the ongoing search for effective treatments for infertility in women with PCOS. It emphasizes the need for personalized treatment plans, considering individual patient characteristics and the potential benefits and risks of different treatment approaches. It's like a caravan navigating a challenging desert landscape: we must adapt our strategies and make informed decisions based on the specific needs of each traveler.

Dr.Camel's Conclusion

This research explores the potential benefits of combining metformin with clomiphene citrate (CC) for ovulation induction in women with PCOS. While further research is needed to determine the optimal duration of metformin pretreatment, the study suggests that this combination therapy can be an effective treatment option for infertility in women with PCOS. It's like finding a hidden oasis in a vast desert: we need to explore different pathways and strategies to optimize treatment outcomes for women with PCOS.

Date :
  1. Date Completed 2008-04-14
  2. Date Revised 2018-12-21
Further Info :

Pubmed ID

18254096

DOI: Digital Object Identifier

10.1002/14651858.CD006226.pub2

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・Effective treatment of polycystic ovary syndrome
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PICO Info
in preparation
Languages

English

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