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Randomised trial of chemotherapy versus endocrine therapy in patients presenting with locally advanced breast cancer (a pilot study).

Author: CoombesR C, FordH T, GazetJ C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 60 patients with locally advanced breast cancer compared primary endocrine therapy with chemotherapy. Chemotherapy led to a faster reduction in tumor size, but there was no significant difference in disease-free survival, local recurrence, distant recurrence, or mortality after 65 weeks.
Paper Details　
Original Abstract of the Article :
Sixty patients with locally advanced breast cancer, but with no evidence of distant metastases were randomised to receive primary endocrine therapy or chemotherapy after assessment and 'Trucut' biopsy of the primary tumour. After 12 weeks all patients were assessed. Eight out of 30 (27%) of the pati...See full text at original site
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引用元：
https://doi.org/10.1038/bjc.1991.65

データ提供：米国国立医学図書館（NLM）

Chemotherapy vs. Endocrine Therapy: A Tale of Two Treatments for Breast Cancer

This pilot study investigates the efficacy of chemotherapy compared to endocrine therapy as primary treatment for locally advanced breast cancer. The researchers randomized 60 patients to receive either chemotherapy or endocrine therapy, monitoring their tumor response over a 12-week period. They found that chemotherapy was more effective in rapidly reducing tumor size compared to endocrine therapy, but there was no significant difference in long-term outcomes such as disease-free survival, local or distant recurrence, or death. This study highlights the complexities of breast cancer treatment and the importance of considering both short-term and long-term outcomes when choosing a treatment strategy.

Chemotherapy: A Powerful Tool, But Not Always the Best Choice

This pilot study provides valuable insights into the relative efficacy of chemotherapy and endocrine therapy for treating locally advanced breast cancer. While chemotherapy was more effective in shrinking tumors in the short term, it did not translate to significant differences in long-term outcomes. This research highlights the importance of carefully considering the individual needs of each patient and the long-term consequences of treatment choices when navigating the challenging landscape of breast cancer therapy.

Navigating the Sands of Breast Cancer Treatment: A Complex Journey

Breast cancer treatment is a complex and often challenging journey. This pilot study provides a glimpse into the relative efficacy of chemotherapy and endocrine therapy, highlighting the importance of carefully considering both short-term and long-term outcomes when choosing a treatment strategy. This research underscores the ongoing need for research to understand the complexities of breast cancer and to develop more effective and personalized treatment approaches.

Dr.Camel's Conclusion

This pilot study suggests that chemotherapy may be a more effective approach for rapidly reducing tumor size in locally advanced breast cancer, but it does not necessarily translate to better long-term outcomes. Further research is needed to fully understand the complexities of breast cancer treatment and to develop more effective and personalized treatment approaches for this challenging disease.
Date :
  1. Date Completed 1991-04-04
  2. Date Revised 2019-05-15
Further Info :

Pubmed ID

1825469

DOI: Digital Object Identifier

10.1038/bjc.1991.65

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

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