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Alternating hepatic intra-arterial floxuridine and fluorouracil: a less toxic regimen for treatment of liver metastases from colorectal cancer.

Author: ChaseJ L, GrobmanB J, HohnD C, LewisB J, MulvihillS J, RaynerA A, RohM, StaggR J, VenookA P, WarrenR S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Alternating hepatic intra-arterial infusion of floxuridine and fluorouracil was found to be an effective and well-tolerated treatment for colorectal cancer metastasized to the liver. In a phase II trial of 68 patients, the regimen achieved a major response rate of 50% and a median survival of 22.4 months, with no patients having treatment terminated due to drug toxicity.
Paper Details　
Original Abstract of the Article :
Hepatic intra-arterial (HIA) infusion of floxuridine (FUDR) via an implanted pump has shown promise in the treatment of colorectal cancer metastasized to the liver. However, the potential benefit of this therapy may be offset by the high incidence of treatment-limiting biliary toxicity. Although wee...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/83.6.423

データ提供：米国国立医学図書館（NLM）

Alternating Hepatic Intra-arterial Floxuridine and Fluorouracil: A Less Toxic Regimen for Treatment of Liver Metastases from Colorectal Cancer

The field of [oncology] is constantly striving to improve the treatment of [cancer] with minimally invasive and less toxic therapies. This study explores a novel approach to treating [liver metastases] from [colorectal cancer] using an alternating regimen of [hepatic intra-arterial (HIA) floxuridine (FUDR)] and [5-fluorouracil (5-FU)]. The researchers employed a [phase II clinical trial] design to evaluate the safety and efficacy of this alternating regimen.

Alternating HIA FUDR and 5-FU: A Safer and More Effective Treatment Option?

The study found that the alternating regimen of [HIA FUDR] and [5-FU] was well-tolerated, with no patients requiring treatment termination due to drug toxicity. Furthermore, the regimen showed promising efficacy, with a significant response rate in the patients enrolled in the trial. These findings suggest that this alternating regimen may be a safer and more effective alternative to existing treatments for [liver metastases] from [colorectal cancer].

Potential Implications for Liver Cancer Treatment

The study's findings offer a promising new approach to treating [liver metastases] from [colorectal cancer]. By minimizing the toxic effects of [HIA FUDR] and [5-FU], this alternating regimen could improve patient outcomes and quality of life. This strategy could be especially beneficial for patients who have previously experienced [treatment-limiting biliary toxicity].

Dr.Camel's Conclusion

This study on alternating [HIA FUDR] and [5-FU] provides a beacon of hope for patients facing [liver metastases] from [colorectal cancer]. The researchers have successfully navigated the desert of cancer treatment, offering a less toxic and potentially more effective approach. This research could pave the way for improved outcomes and quality of life for patients battling this challenging disease.

Date :
  1. Date Completed 1991-04-05
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

1825674

DOI: Digital Object Identifier

10.1093/jnci/83.6.423

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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