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Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients.

Author: HannaMagdi, O'BrienCathy, WilsonMargaret C

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study highlights the difficulty in treating neuropathic pain, a condition that is often under-diagnosed and poorly managed. Current treatments are not always effective, with less than half of patients achieving significant pain relief and many experiencing persistent pain. The study also mentions the limitation of increasing medication doses due to potential side effects.
Paper Details　
Original Abstract of the Article :
Neuropathic pain remains one of the most challenging pain syndromes; under-diagnosed, poorly managed and associated with significant co-morbidity. With standard therapeutic treatments, responders rarely exceed 50% pain relief and the majority suffer from residual pain. Titration to optimum dose is o...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpain.2007.12.010

データ提供：米国国立医学図書館（NLM）

Prolonged-Release Oxycodone for Painful Diabetic Neuropathy

The experience of [neuropathic pain], especially in the context of [diabetic neuropathy], can be a truly debilitating one, like navigating a desert filled with scorching heat and sharp rocks. This study, like a compassionate guide offering a refreshing oasis, investigates the potential of [prolonged-release oxycodone] to enhance the effectiveness of existing [gabapentin therapy] for patients suffering from [painful diabetic neuropathy].

A Potential Solution for Unremitting Pain

The study found that [prolonged-release oxycodone] significantly enhanced the pain-relieving effects of [gabapentin therapy] in patients with [painful diabetic neuropathy]. This discovery is like finding a hidden spring in the desert, providing much-needed relief for those who have struggled to find adequate pain management. The researchers also noted that [titration to optimal dose] was possible with fewer [dose-related adverse events], making this approach even more promising.

Improving Pain Management for Diabetic Neuropathy

The study suggests that [combination therapy] with [prolonged-release oxycodone] and [gabapentin] may provide a more effective and tolerable solution for patients with [painful diabetic neuropathy]. It's like building a sturdy shelter in the desert, providing protection and respite from the harsh elements.

Dr.Camel's Conclusion

This study offers hope for patients with painful diabetic neuropathy, demonstrating that combination therapy with prolonged-release oxycodone and gabapentin can significantly improve pain management. It's like finding a hidden oasis in the desert of pain, providing much-needed relief and improving the quality of life for those suffering from this debilitating condition.

Date :
  1. Date Completed 2008-08-20
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

18262450

DOI: Digital Object Identifier

10.1016/j.ejpain.2007.12.010

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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