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Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results.

Author: ContuPaolo, DeianaLaura, DessìMariele, FlorisCarlo, GramignanoGiulia, MacciòAntonio, MadedduClelia, MantovaniGiovanni, MassaElena, PanzoneFilomena, SannaEleonora, SerpeRoberto, TancaFrancesca Maria

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study describes a phase III randomized study aimed at establishing the most effective and safest treatment for cancer-related anorexia/cachexia syndrome and oxidative stress. It identifies primary endpoints for evaluating treatment effectiveness.
Paper Details　
Original Abstract of the Article :
In April 2005 a phase III randomized study was started to establish which was the most effective and safest treatment of cancer-related anorexia/cachexia syndrome and oxidative stress in improving identified primary endpoints: increase of lean body mass, decrease of resting energy expenditure (REE),...See full text at original site
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引用元：
https://doi.org/10.1016/j.nut.2007.12.010

データ提供：米国国立医学図書館（NLM）

Combatting Cancer Cachexia: A Randomized Trial of Five Treatments

Cancer cachexia, a debilitating syndrome characterized by weight loss and muscle wasting, poses a formidable challenge in the fight against cancer. This randomized phase III clinical trial investigates the efficacy of five different treatment approaches for cancer cachexia. It's like a group of explorers venturing into a harsh desert, seeking to find the most effective way to combat the devastating effects of this condition.

Finding a Oasis in the Desert of Cachexia

The trial aims to identify the most effective and safe treatment for cancer-related anorexia/cachexia syndrome, focusing on improving key endpoints such as lean body mass, resting energy expenditure, physical activity, and inflammatory markers. It's like searching for a hidden oasis amidst the desolate sands, offering hope for those battling this debilitating condition.

A Multi-pronged Approach to Combat Cachexia

This research highlights the complexity of managing cancer cachexia and the need for a multidisciplinary approach. It underscores the importance of addressing not only the physical symptoms but also the psychological and social aspects of this condition. Just as a camel needs a well-stocked caravan to survive a long desert journey, patients with cancer cachexia require a comprehensive care plan.

Dr.Camel's Conclusion

This clinical trial represents a significant step forward in our understanding of cancer cachexia. It underscores the importance of a multidisciplinary approach, combining pharmacological and non-pharmacological interventions to improve the quality of life for patients battling this debilitating condition. Just as a camel adapts to the harsh desert environment, we must continue to seek innovative solutions to combat this challenging disease.

Date :
  1. Date Completed 2008-06-30
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

18262758

DOI: Digital Object Identifier

10.1016/j.nut.2007.12.010

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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