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[Prevention of ossification after total hip endoprosthesis with indomethacin and its effect on gastric mucosa].

Author: CardaC, KnahrK, KuchnerG, MetzenrothH, PubligW, ZandlC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Ranitidine and sucralfate were both found to effectively prevent ulcers in patients receiving indomethacin as a prophylactic against heterotopic ossification after total hip joint replacement. The study included 3 groups: ranitidine, sucralfate, and placebo. Both ranitidine and sucralfate were effective in preventing ulcers, and indomethacin was effective in preventing heterotopic ossification.
Paper Details　
Original Abstract of the Article :
The administration of indomethacin as a prophylactic against heterotopic ossification following the implantation of total hip-joint endoprosteses entails the risk of gastrointestinal side-effects. A prospective randomized study set out to determine the effectiveness of ranitidine and sucralfate as a...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1055/s-2008-1040179

データ提供：米国国立医学図書館（NLM）

Indomethacin: A Double-Edged Sword in Hip Replacement

The world of orthopedic surgery is a realm of precision and innovation, with procedures like total hip replacement offering relief from debilitating pain and restoring mobility. This study explores the use of indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), as a prophylactic measure to prevent ossification after total hip replacement, while also addressing the potential gastrointestinal side effects of this medication.

A Balancing Act: Managing Benefits and Risks

The study highlights the effectiveness of indomethacin in preventing ossification, a condition that can occur after hip replacement and limit joint mobility. However, the study also acknowledges the potential for gastrointestinal side effects, like ulcers, associated with indomethacin use. It's like navigating a delicate balance between the benefits and risks of a desert journey, where the oasis of relief may be accompanied by challenges along the way.

A Protective Strategy: Minimizing Gastrointestinal Side Effects

The study investigated the use of ranitidine and sucralfate as secondary treatments to protect the stomach from the potential side effects of indomethacin. These protective measures, like carrying extra supplies and taking precautions during a desert expedition, can help minimize the risks associated with using indomethacin. The results show that both ranitidine and sucralfate effectively prevented the development of ulcers, demonstrating the importance of comprehensive strategies for managing the potential side effects of medications.

Dr. Camel's Conclusion

This study, like a camel guide leading a caravan through a complex desert landscape, explores the benefits and challenges of using indomethacin after total hip replacement. The study emphasizes the importance of balancing the potential benefits of this medication with the need to mitigate its gastrointestinal side effects, reminding us that even the most promising solutions can have unforeseen consequences.

Date :
  1. Date Completed 1991-08-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1829300

DOI: Digital Object Identifier

10.1055/s-2008-1040179

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SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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