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Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report.

Author: ShieldsJohn A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Neostigmine, a muscle relaxant reversal agent, can cause heart block and prolong the Q-Tc interval, especially in patients with predisposing factors like morbid obesity. This was observed in a patient who received a combination of anesthetic agents, including desflurane, droperidol, dolasetron, and dexmedetomidine. The heart block resolved after atropine administration, but the prolonged P-R and Q-Tc intervals persisted for a few hours. This case highlights the importance of considering multiple factors that may influence Q-T interval prolongation during anesthesia.
Paper Details　
Original Abstract of the Article :
Heart block and Q-Tc interval prolongation have been reported with several agents used in anesthesia, and the US Food and Drug Administration mandates evaluation of the Q-T interval with new drugs. Drug-induced Q-T interval prolongation may precipitate life-threatening arrhythmias, is considered a p...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18323319

データ提供：米国国立医学図書館（NLM）

Heart Block and Prolonged QT Interval: A Complex Interaction

This case report explores a serious complication involving heart block and prolonged QT interval, both potentially life-threatening arrhythmias. The authors present a case where these complications arose after muscle relaxant reversal with neostigmine, highlighting the complex interaction between anesthetic agents. The research raises concerns about the potential for drug-induced QT prolongation, underscoring the importance of careful drug selection and monitoring during anesthesia.

A Cautionary Reminder: The Importance of Patient Monitoring

The study emphasizes the need for meticulous patient monitoring during anesthesia to identify and manage potential drug-induced cardiac complications. This research highlights the importance of being aware of potential drug interactions and carefully monitoring patient vital signs during procedures, especially when using multiple medications.

Heart Health: A Journey Through the Complexities of Medicine

The heart is a remarkable organ, and its delicate electrical system can be influenced by various factors. This research reminds us that understanding drug interactions and monitoring patient health is crucial for ensuring patient safety. As a researcher, I find it fascinating how the human body, much like a vast desert landscape, holds many hidden complexities and challenges.
Date :
  1. Date Completed 2008-04-11
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18323319

DOI: Digital Object Identifier

18323319

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Article Analysis
・Effects of dolasetron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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