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Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors.

Author: AbreyLauren, ArmandJean-Pierre, HarrousseauJean-Luc, RibragVincent

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study reviewed the use of procarbazine, an alkylating anticancer agent, in treating Hodgkin's lymphoma and brain tumors. Procarbazine is effective in combination with other drugs but has side effects including gastrointestinal disturbances, myelosuppression, and central nervous system effects.
Paper Details　
Original Abstract of the Article :
Procarbazine HCl is a 'nonclassical' oral alkylating anticancer agent that was first synthesized in the late 1950s. It has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's lymphoma and brain tumors and, to a lesser extent, Non-Hodgkin's lymphoma and prima...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936303/

データ提供：米国国立医学図書館（NLM）

Procarbazine: A Versatile Weapon in the Fight Against Cancer

Cancer, a formidable foe like a sandstorm that can engulf everything in its path, requires a multifaceted approach for treatment. This research examines the use of procarbazine, an anticancer agent, in the treatment of lymphomas and brain tumors. It's like exploring a vast desert, seeking the right tools and strategies to overcome the challenges that lie ahead.

The History and Evolution of Procarbazine

The study delves into the history of procarbazine, highlighting its early use in combination with other drugs for advanced Hodgkin's lymphoma. It's like discovering an ancient artifact that reveals a hidden chapter in the fight against cancer. While procarbazine's use declined due to potential side effects, its recent reintroduction in new regimens has yielded promising results.

A Versatile Tool for Cancer Treatment

Procarbazine's versatility is its strength, like a camel that can carry different types of cargo. The study highlights its effectiveness in treating gliomas, a type of brain tumor, and its potential as a part of a multi-drug approach for various cancers. However, it's important to be mindful of its side effects, like navigating a desert with potential pitfalls along the way.

Dr. Camel's Conclusion

Procarbazine remains a significant weapon in the fight against cancer, particularly for certain lymphomas and brain tumors. It's like a seasoned desert traveler, equipped with the knowledge and tools to navigate the challenges and find success.
Date :
  1. Date Completed 2011-07-14
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

18360630

DOI: Digital Object Identifier

PMC1936303

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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