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[Antidepressants with different action mechanisms in the treatment of chronic daily headache].

Author: AmelinA V, IgnatovIu D, MiatlevaM I, SkorometsA A, TarasovaS V

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study compared the efficacy and safety of four antidepressants in treating chronic daily headache. All antidepressants were effective, especially for patients with depressive and anxiety symptoms. Milnacipran and amitryptiline were most effective, while escitalopram and milnacipran had fewer side effects.
Paper Details　
Original Abstract of the Article :
Efficacy and safety of the following antidepressants: amitryptiline (tricyclic antidepressant), escitalopram (selective inhibitor of serotonin reuptake), milnacipran (selective inhibitor of serotonin and noradrenalin reuptake) and maprotiline (selective inhibitor of noradrenalin reuptake) have been ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18379461

データ提供：米国国立医学図書館（NLM）

The Role of Antidepressants in Chronic Daily Headache

Chronic daily headache, a debilitating condition characterized by persistent pain, can have a significant impact on quality of life. This research investigates the effectiveness of various antidepressants in treating chronic daily headache, focusing on the potential benefits of different drug mechanisms. The researchers compared the efficacy and safety of four different antidepressants, amitriptyline, escitalopram, milnacipran, and maprotiline, in a group of patients with chronic daily headache.

Antidepressants and Headache Management

The study found that all four antidepressants showed positive effects in treating chronic daily headache, particularly in patients with accompanying depressive or anxiety symptoms. This research provides valuable insights into the potential role of antidepressants in managing headache disorders. The researchers concluded that the combination of noradrenergic and serotonergic components in antidepressants, particularly milnacipran, seemed to be most effective in treating chronic daily headache.

Exploring Treatment Options for Chronic Headache

This study underscores the importance of exploring different treatment options for chronic daily headache, considering the potential benefits of antidepressants. The researchers' findings provide valuable information for healthcare professionals seeking to optimize treatment strategies for patients with this debilitating condition.

Dr.Camel's Conclusion

The desert of chronic daily headache can be a challenging place to navigate. This research suggests that antidepressants can be a valuable oasis in this landscape, offering relief from the persistent pain and improving overall quality of life.
Date :
  1. Date Completed 2008-09-11
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

18379461

DOI: Digital Object Identifier

18379461

Related Literature

Article Analysis
・Side Effects of maprotiline
SNS
PICO Info
in preparation
Languages

Russian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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