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Influence of UDP-glucuronosyltransferase polymorphisms on mycophenolate mofetil-induced side effects in kidney transplant patients.

Author: Abbud-FilhoM, AlvarengaM P S, Benoit-BiancamanoM-O, BetônicoG N, Goloni-BertolloE M, GuillemetteC, Pavarino-BertelliE C, VilleneuveL

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mycophenolate mofetil (MMF) is a drug used to prevent organ rejection after transplantation. Its effectiveness can be influenced by genetic variations in UDP-glucuronosyltransferase (UGT) enzymes, which are involved in its metabolism.
Paper Details　
Original Abstract of the Article :
Mycophenolate mofetil (MMF) is an immunosuppressive prodrug approved for use in transplantation. Its active metabolite, mycophenolic acid, is mainly metabolized by UDP-glucuronosyltransferase (UGT) enzymes. In this study, we retrospectively analyzed 74 kidney transplant patients who had been prescri...See full text at original site
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引用元：
https://doi.org/10.1016/j.transproceed.2008.03.007

データ提供：米国国立医学図書館（NLM）

The Influence of Genetics: Mycophenolate Mofetil and Kidney Transplant

Mycophenolate mofetil (MMF) is an immunosuppressive drug commonly used after kidney transplantation. This study, like a desert explorer mapping the intricate pathways of the body, investigates the influence of UDP-glucuronosyltransferase (UGT) polymorphisms on MMF-induced side effects in kidney transplant patients. The researchers analyzed data from 74 patients who received MMF as part of their immunosuppression regimen.

The researchers found that specific UGT1A8 polymorphisms, like variations in a desert landscape, were associated with an increased risk of certain side effects, such as infections, in patients receiving MMF. Their findings suggest that these genetic variations could play a role in individual responses to MMF therapy.

A Personalized Approach to Immunosuppression

This study, like a desert oasis providing tailored resources, highlights the importance of considering individual genetic differences when prescribing immunosuppressants. The findings underscore the need for personalized approaches to optimize patient outcomes.

Navigating the Complexities of Transplant Care

This research, like a desert expedition navigating challenging terrain, delves into the complexities of immunosuppression therapy after kidney transplantation. The study's findings underscore the need for continued research and personalized treatment approaches in this field.

Dr.Camel's Conclusion

This study emphasizes the importance of considering genetic variations in UGT1A8 when prescribing MMF to kidney transplant patients. The researchers' findings highlight the need for personalized approaches to minimize side effects and optimize outcomes in this vulnerable population.

Date :
  1. Date Completed 2008-08-11
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

18454993

DOI: Digital Object Identifier

10.1016/j.transproceed.2008.03.007

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in preparation
Languages

English

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