[Schizophrenia as a brain disorder and its development].

Author: FalkaiP, GruberO, Schneider-AxmannT, WobrockT

Paper Details 
Original Abstract of the Article :
Schizophrenia is a psychiatric disease associated with functional und structural brain abnormalities. Beside global deficits, like a reduction of the whole brain volume and an enlargement of the ventricular system, there are circumscribed changes especially in the gray matter of the frontal lobe. Re...See full text at original site
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引用元:
https://doi.org/10.1055/s-2008-1038142

データ提供:米国国立医学図書館(NLM)

Schizophrenia as a Brain Disorder

Schizophrenia is a complex and often misunderstood psychiatric disorder. This article delves into the neurobiological basis of schizophrenia, exploring the structural and functional brain abnormalities associated with the disease. The authors discuss the potential causes of these abnormalities, including genetic vulnerability, environmental factors, and the effects of treatment.

Neurobiological Changes in Schizophrenia

The study highlights the intricate relationship between brain structure and function in schizophrenia. The authors suggest that the neurobiological changes associated with schizophrenia are complex and likely vary depending on the stage of the illness. They propose that a hypofunction of the GABAergic system may contribute to vulnerability to the disorder, while a destabilization of the glutamatergic system may be involved in the first manifestation of symptoms. It's like observing a desert landscape undergoing a series of transformations, with each stage presenting unique challenges and opportunities. By understanding these dynamic changes, we can gain a deeper insight into the mechanisms of schizophrenia and develop more effective treatments.

Implications for Treatment Strategies

This research underscores the importance of developing targeted therapies that address the specific neurobiological changes associated with schizophrenia. The authors propose that pharmacological interventions that target the GABAergic and glutamatergic systems could be particularly effective. By understanding the neurobiological underpinnings of this complex disorder, we can develop more personalized and effective treatment strategies for patients with schizophrenia. Think of it like finding the right path through a complex desert ecosystem, where each route requires a unique understanding of the terrain and its challenges.

Dr.Camel's Conclusion

This article provides a comprehensive overview of the neurobiological changes associated with schizophrenia, highlighting the complex interplay between brain structure and function in this debilitating disorder. The research emphasizes the need for further research to develop more targeted and effective treatments for schizophrenia, offering hope for a brighter future for those affected by this condition.

Date :
  1. Date Completed 2008-07-18
  2. Date Revised 2008-05-07
Further Info :

Pubmed ID

18461547

DOI: Digital Object Identifier

10.1055/s-2008-1038142

Related Literature

SNS
PICO Info
in preparation
Languages

German

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