Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

Author: ZhouShu-Feng

Paper Details 
Original Abstract of the Article :
Human cytochrome P450 (CYP) 3A4 is the most abundant hepatic and intestinal phase I enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound and unbound CYP3A4 has been recently constructed, and a small active site and a peripheral binding site are identified. A recen...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.2174/138920008784220664

データ提供:米国国立医学図書館(NLM)

The Complex Dance of Drugs and CYP3A4: A Molecular Symphony

The field of drug metabolism is a fascinating journey into the molecular mechanisms that govern how our bodies process medications. This study focuses on a key enzyme, CYP3A4, and its multifaceted role in the metabolism of various drugs.

The researchers delve into the complex interactions between drugs and CYP3A4, a vital enzyme that plays a significant role in the metabolism of a wide range of medications. They explore how drugs can act as substrates, inhibitors, and inducers of CYP3A4, influencing their own metabolism and the metabolism of other drugs.

The Importance of Understanding Drug Interactions

This study highlights the critical importance of understanding drug interactions mediated by CYP3A4. It emphasizes that the concurrent use of certain drugs can significantly alter the metabolism and effectiveness of other medications, potentially leading to adverse effects.

Navigating the Labyrinth of Drug Interactions: A Guide for Patients and Clinicians

This research provides valuable information for both patients and clinicians alike. Patients should be aware of the potential for drug interactions and discuss any concerns with their healthcare provider. Clinicians need to be vigilant in considering potential interactions, especially when prescribing drugs that are known to be substrates, inhibitors, or inducers of CYP3A4.

Dr.Camel's Conclusion

Imagine the desert as a vast network of interconnected dunes, where each drug is like a grain of sand, flowing through the system. This study explores how drugs interact with a vital enzyme, CYP3A4, affecting their own journey and the journeys of other drugs. It reminds us that understanding these interactions is crucial to ensure safe and effective treatment.

Date :
  1. Date Completed 2008-06-30
  2. Date Revised 2019-10-27
Further Info :

Pubmed ID

18473749

DOI: Digital Object Identifier

10.2174/138920008784220664

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.