Side Effects of delavirdine: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Key Research Findings

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV infection. 、 10 、 6 It is used in combination with other antiretroviral drugs to suppress the growth of HIV. 10 Delavirdine was approved by the US Food and Drug Administration (FDA) in 1997. 、 Studies show that delavirdine, in combination with other antiretroviral drugs, can be effective in suppressing viral load and increasing CD4 cell counts. 8 、 7 However, it is important to note that delavirdine can also cause side effects. 7 Understanding the side effects of delavirdine and taking appropriate precautions in the treatment of HIV infection is crucial. 4

Reasons for Side Effects

The side effects of delavirdine can occur when the drug is metabolized in the body. 4 Delavirdine is metabolized by the liver enzyme cytochrome P450 3A4 (CYP3A4). 4 CYP3A4 is involved in the metabolism of many drugs, and delavirdine acts as an inhibitor of CYP3A4. 4 Inhibition of CYP3A4 can increase the blood concentration of delavirdine, increasing the risk of side effects. 4

Common Side Effects

Rash

Delavirdine can cause a rash. 8 、 7 A rash occurs in about 30% of patients taking delavirdine. 8 Rashes usually occur within a few weeks of starting delavirdine. 8 Rashes can range from mild to severe. 8 Severe rashes can cause Stevens-Johnson syndrome or toxic epidermal necrolysis. 8 These symptoms can be life-threatening, so you need to see a doctor. 8

Liver Side Effects

Delavirdine can cause liver side effects. 7 Liver side effects can cause inflammation of the liver and impaired liver function. 7 These symptoms can be life-threatening, so you need to see a doctor. 7

Central Nervous System Side Effects

Delavirdine can cause central nervous system side effects. 7 Central nervous system side effects include dizziness, headache, drowsiness, decreased concentration, and confusion. 7

Gastrointestinal Side Effects

Delavirdine can cause gastrointestinal side effects. 8 Gastrointestinal side effects include nausea, vomiting, diarrhea, and abdominal pain. 8

Measures to Prevent Side Effects

Rash

If you develop a rash, you should see a doctor. 8 Your doctor will identify the cause of the rash and determine the appropriate treatment. 8 If the rash is severe, you may need to stop taking delavirdine. 8

Liver Side Effects

If you develop liver side effects, you should see a doctor. 7 Your doctor will test your liver function and determine the appropriate treatment. 7 If liver side effects are severe, you may need to stop taking delavirdine. 7

Central Nervous System Side Effects

If you develop central nervous system side effects, you should see a doctor. 7 Your doctor will identify the cause of the side effects and determine the appropriate treatment. 7 If central nervous system side effects are severe, you may need to stop taking delavirdine. 7

Gastrointestinal Side Effects

If you develop gastrointestinal side effects, you should see a doctor. 8 Your doctor will identify the cause of the side effects and determine the appropriate treatment. 8 If gastrointestinal side effects are severe, you may need to stop taking delavirdine. 8

Comparison of Research

Similarities in Research

The main side effects of delavirdine are rash, liver side effects, central nervous system side effects, and gastrointestinal side effects. 8 、 7 These side effects may occur within a few weeks of starting delavirdine. 8 Side effects can range from mild to severe. 8 Severe side effects can be life-threatening. 8 These symptoms need to be seen by a doctor. 8

Differences in Research

Each study shows differences in the incidence and severity of delavirdine side effects. 8 、 7 This may be influenced by various factors such as the patient's age, sex, health status, and other medications taken. 8 、 7

Precautions for Real-Life Applications

Delavirdine is an important drug in the treatment of HIV infection. 7 However, since delavirdine can cause side effects, it is important to take it as directed by your doctor. 7 If you experience any side effects, consult your doctor immediately. 7

Limitations of Current Research

There is still not enough research on the side effects of delavirdine. 8 、 7 More research is needed. 8 、 7

Future Research Directions

We need to elucidate the mechanism of delavirdine's side effects and develop new treatments to prevent or reduce side effects. 4 In addition, large-scale clinical trials are needed to more accurately assess the incidence and severity of delavirdine side effects. 8 、 7

Conclusion

Delavirdine is an important drug in the treatment of HIV infection, but it can cause side effects. 7 It is important to understand the side effects of delavirdine and take appropriate precautions in the treatment of HIV infection. 4 Take delavirdine as directed by your doctor, and if you experience any side effects, consult your doctor immediately. 7

Literature analysis of 10 papers
Positive Content
9
Neutral Content
0
Negative Content
1
Article Type
1
0
0
7
10
2.

Developments of indoles as anti-HIV-1 inhibitors.

Author: XuHui, LvMin

Anti-HIV-1 activity

This review examines the synthesis and anti-HIV-1 activity of indole derivatives, a promising class of HIV-1 inhibitors. The review also discusses the structure-activity relationship (SAR) for some derivatives, paving the way for the design of new indole derivatives as anti-HIV-1 drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

Author: ZhouShu-Feng

Drug metabolism
Drug-drug interactions
Toxicity

Human cytochrome P450 (CYP) 3A4 is a crucial enzyme that metabolizes approximately 50% of marketed drugs. This article discusses the substrates, inducers, and inhibitors of CYP3A4, and the importance of understanding drug-drug interactions related to this enzyme.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.

Author: ZhouShu-Feng, XueCharlie Changli, YuXue-Qing, LiChunguang, WangGuangji

Drug interactions
Toxicity

Cytochrome P450 (CYP) 3A4 is a key enzyme involved in the metabolism of many drugs. Mechanism-based inhibition of CYP3A4 can lead to drug-drug interactions and potentially fatal toxicity. This article provides information on clinically important mechanism-based CYP3A4 inhibitors and strategies to minimize drug interactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors).

Author: ZaporMichael J, CozzaKelly L, WynnGary H, WortmannGlenn W, ArmstrongScott C

Antiretroviral therapy
Drug interactions
Side effects
Toxicities

This review summarizes non-protease inhibitor antiretroviral drugs, including nucleoside and nucleotide analogue reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), and cell membrane fusion inhibitors. It explains how these drugs work, their side effects, toxicities, and drug interactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Efficacy and safety of delavirdine mesylate with zidovudine and didanosine compared with two-drug combinations of these agents in persons with HIV disease with CD4 counts of 100 to 500 cells/mm3 (ACTG 261). ACTG 261 Team.

Author: FriedlandG H, PollardR, GriffithB, HughesM, MorseG, BassettR, FreimuthW, DemeterL, ConnickE, NevinT, HirschM, FischlM

HIV-1 treatment
Gastrointestinal side effects
Rash

Delavirdine + zidovudine + didanosine was safe and showed modest antiviral activity and CD4 cell count benefit compared with two-drug regimens in patients with HIV-1 infection. Gastrointestinal side effects and rash were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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