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Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis.

Author: HashizumeMisato, MiharaMasahiko, MoriyaYoichiro, UchiyamaYasushi, YorozuKeigo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tocilizumab is a drug that blocks the interleukin-6 receptor, which is involved in inflammation. This study found that tocilizumab reduced joint swelling in monkeys with arthritis. The study suggests that tocilizumab could be used to treat arthritis in humans.
Paper Details　
Original Abstract of the Article :
We examined if tocilizumab, humanized anti-interleukin-6 receptor (IL-6R) antibody, can ameliorate joint swelling after the onset of arthritis in collagen-induced arthritis (CIA). CIA was induced by the immunization of bovine type II collagen in female cynomolgus monkeys. Tocilizumab (30 mg/kg) was ...See full text at original site
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引用元：
https://doi.org/10.1248/bpb.31.1159

データ提供：米国国立医学図書館（NLM）

Tocilizumab: A Potential Oasis in the Desert of Arthritis

[Collagen-induced arthritis (CIA)] is a debilitating condition that affects millions of people worldwide. This study explores the potential of [tocilizumab], a [humanized anti-interleukin-6 receptor (IL-6R) antibody], to offer relief from the harsh conditions of [CIA]. It is like discovering a new oasis in the desert of [arthritis], offering hope for a more comfortable life for patients. The study found that [tocilizumab] effectively reduced [joint swelling] in monkeys with [CIA], suggesting that it may be a valuable treatment option for humans as well.

Tocilizumab's Potential for Arthritis Treatment

The results of this study demonstrate the potential of [tocilizumab] as a treatment for [CIA]. The [reduction in joint swelling] observed in monkeys is a significant finding, suggesting that this medication could provide relief for patients struggling with this debilitating condition.

Hope for a More Comfortable Life

This study provides a glimmer of hope for patients with [CIA]. The discovery of [tocilizumab] as a potential treatment option offers the promise of a more comfortable life, free from the pain and limitations associated with this condition.

Dr.Camel's Conclusion

This study is a testament to the ongoing search for effective treatments for [arthritis]. Like a camel seeking out a hidden oasis in the vast desert, the authors have discovered a potential solution in the form of [tocilizumab]. This is a significant step towards improving the lives of patients suffering from this chronic condition.

Date :
  1. Date Completed 2008-06-30
  2. Date Revised 2019-07-20
Further Info :

Pubmed ID

18520048

DOI: Digital Object Identifier

10.1248/bpb.31.1159

Related Literature

Article Analysis
・Effects of tocilizumab injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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