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Antiobesity effects of the beta-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats.

Author: AthanacioJ, CoffeyT, KestyN C, LeiC, MackC, ParkesD G, RothJ D, TrevaskisJ L, WeyerC, WilsonJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In a study of rats with diet-induced obesity, combining amylin with phentermine or sibutramine resulted in greater reductions in food intake and body weight than either drug alone.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To characterize the interactive effects of amylin with phentermine or sibutramine on food intake, body weight/composition and gene expression in diet-induced obese (DIO) rats. DESIGN: DIO rats were intraperitoneally injected with a single dose of amylin (10 microg kg(-1)) and/or phenterm...See full text at original site
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引用元：
https://doi.org/10.1038/ijo.2008.91

データ提供：米国国立医学図書館（NLM）

Amylin: A Potential Ally in the Fight Against Obesity

Obesity is a global health concern, affecting millions of people. This study explores the potential of amylin, a hormone produced by the pancreas, as a weapon against obesity. Researchers investigated the effects of amylin, either alone or in combination with other anti-obesity drugs, on diet-induced obese rats.

Amylin's Synergistic Effects: A Powerful Partnership

The results revealed that amylin, when combined with phentermine or sibutramine, significantly reduced food intake, body weight, and fat mass in obese rats. Imagine amylin as a desert oasis, offering relief from the hunger pangs of obesity. These findings suggest that amylin could play a vital role in future anti-obesity therapies, potentially offering a new avenue for effective weight management.

Hope for the Future: A Glimpse into a Healthier Tomorrow

This research opens up exciting possibilities for tackling obesity, a growing health problem. While more research is needed, this study offers a promising glimpse into the future of obesity management.

Dr.Camel's Conclusion

This study suggests that amylin, a hormone produced by the pancreas, could be a powerful weapon in the fight against obesity. It's like finding a hidden spring in the desert—a source of hope for a healthier future!

Date :
  1. Date Completed 2009-01-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18560368

DOI: Digital Object Identifier

10.1038/ijo.2008.91

Related Literature

Article Analysis
・Effects of phentermine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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