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A trend analysis of changes during treatment of panic disorder with alprazolam and imipramine.

Author: BechP, LorentzenK, MellergårdM, OttossonJ O, RosenbergR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study of 123 patients with panic disorder compared the effects of alprazolam and imipramine on various symptoms. Alprazolam demonstrated a quicker improvement in panic attack frequency and avoidance behaviors, while imipramine showed a more gradual improvement in overall symptoms. The study also found that the duration of illness, gender, and history of depression impacted the rate of improvement. This suggests that different treatment approaches and timelines may be needed for patients with panic disorder, depending on their individual characteristics.
Paper Details　
Original Abstract of the Article :
A total of 123 Scandinavian patients participated in a cross-national study of panic disorder. Twelve outcome measures, including number of panic attacks and phobias, have been used to describe changes in symptoms during treatment. This article gives a trend analysis of remission for each variable, ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0447.1991.tb03098.x

データ提供：米国国立医学図書館（NLM）

Alprazolam and Imipramine for Panic Disorder: A Tale of Two Therapies

Panic disorder, a condition characterized by sudden episodes of intense fear and anxiety, can be a challenging journey through the desert of mental health. This research explores the efficacy of two different treatments for panic disorder, alprazolam (a benzodiazepine) and imipramine (a tricyclic antidepressant).

The study utilized a cross-national approach, gathering data from 123 Scandinavian patients with panic disorder. The researchers analyzed the changes in symptoms, such as the number of panic attacks and phobias, during treatment with either alprazolam or imipramine. The findings revealed distinct patterns of symptom improvement based on the treatment received.

Alprazolam: A Quick Oasis, Imipramine: A Slower Journey

Alprazolam was found to have a rapid effect on reducing the frequency and severity of panic attacks, acting like a quick oasis in the desert. However, imipramine demonstrated a more gradual improvement in overall symptoms, suggesting a slower but potentially more sustainable path towards recovery. The researchers also identified factors such as the duration of illness, sex, and history of depression that influenced the sequence of improvement, highlighting the complexity of mental health conditions.

Navigating the Path to Recovery

This research offers valuable insights into the different ways that these two medications can help individuals with panic disorder. Understanding the unique characteristics of these treatments is crucial for tailoring treatment plans and maximizing the chances of recovery. Like a skilled camel navigating the desert, clinicians must carefully assess each patient's needs and guide them towards the most appropriate path to wellness.

Dr. Camel's Conclusion

This study sheds light on the nuances of treating panic disorder. It's important to acknowledge the distinct pathways to recovery offered by alprazolam and imipramine, each with its own set of benefits and challenges. This underscores the importance of individualized treatment plans and the ongoing need for research to better understand the complexities of mental health.

Date :
  1. Date Completed 1991-09-05
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

1862731

DOI: Digital Object Identifier

10.1111/j.1600-0447.1991.tb03098.x

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・Effective treatment of panic disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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