Paper Details 
Original Abstract of the Article :
Acitretin is one of the first line drugs to treat psoriasis, though the mechanisms are not fully clear. It has been reported that psoriatic keratinocytes secreted high level of RANTES, which can induce chemotaxis and activation of T cells, thus may play an important role in the pathogenesis of psori...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1007/s00403-008-0872-z

データ提供:米国国立医学図書館(NLM)

Acitretin: A Multifaceted Approach to Managing Psoriasis

The field of [dermatology] is constantly seeking effective treatments for [psoriasis], a chronic skin condition that affects millions worldwide. This research investigates the multifaceted effects of [acitretin], a commonly used medication for psoriasis, on human keratinocytes. The study focused on the effects of acitretin on [keratinocyte proliferation] and [RANTES production], key factors involved in the pathogenesis of psoriasis. The researchers found that acitretin significantly inhibited the proliferation of HaCaT cells, a human keratinocyte cell line, and reduced RANTES production, suggesting its potential for managing psoriasis by targeting these critical pathways.

Acitretin: A Potential Multi-Target Therapy for Psoriasis

The study highlights the [multifaceted effects] of [acitretin] in [managing psoriasis]. The researchers meticulously investigated the effects of acitretin on keratinocyte proliferation and RANTES production, demonstrating its potential to inhibit key pathways involved in the development of psoriasis. These findings suggest that acitretin could be a valuable treatment option for psoriasis, offering a multi-target approach to managing this complex skin condition.

Psoriasis: A Journey for Skin Health

Psoriasis is a chronic skin condition that can significantly impact quality of life. This study provides insights into the potential of [acitretin] as a [multi-target therapy] for managing psoriasis. The researchers meticulously investigated the effects of acitretin on keratinocyte proliferation and RANTES production, demonstrating its ability to target key pathways involved in the development of this complex skin condition. While further research is needed to fully understand its therapeutic potential, the findings offer a promising avenue for developing effective treatments for psoriasis.

Dr.Camel's Conclusion

Just like a camel navigating a vast and unforgiving desert, managing psoriasis can be a challenging journey. This study offers a refreshing oasis in the form of acitretin, a medication that demonstrates potential for managing psoriasis by targeting key pathways involved in its development. While further research is needed, the findings suggest that acitretin could be a valuable tool for managing this chronic skin condition, offering a multi-target approach to improving skin health and quality of life for patients.

Date :
  1. Date Completed 2008-12-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18629525

DOI: Digital Object Identifier

10.1007/s00403-008-0872-z

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Languages

English

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