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Pharmacological interventions for the prevention of relapse in bipolar disorder: a systematic review of controlled trials.

Author: BeynonS, DuffyS, GeddesJ R, Soares-WeiserK, WoolacottN

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review of 34 studies on preventing bipolar disorder relapses found that lithium, valproate, and lamotrigine were effective in preventing relapses. Lithium, olanzapine, and aripiprazole were effective in preventing manic episodes, while valproate, lamotrigine, and imipramine were effective in preventing depressive symptoms. Imipramine is not commonly used due to side effects. Although widely used, combination therapy lacks strong evidence for effectiveness.
Paper Details　
Original Abstract of the Article :
We conducted a systematic review and meta-analysis of randomised and quasi-randomised controlled trials evaluating all clinically relevant pharmacological interventions for the prevention of relapse in people with bipolar disorder. Thirty-four trials were included in the review. Direct comparisons w...See full text at original site
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引用元：
https://doi.org/10.1177/0269881108093885

データ提供：米国国立医学図書館（NLM）

A Comprehensive Look at Bipolar Disorder Relapse Prevention

This research dives into the vast desert of bipolar disorder, a condition that throws individuals on a rollercoaster of moods. The researchers focused on pharmacological interventions, which are like oases in the desert, providing relief and stability. They conducted a systematic review and meta-analysis of controlled trials, meticulously examining the effectiveness of various drugs in preventing relapse. They discovered that lithium, valproate, and lamotrigine emerged as reliable and effective treatments, acting like sturdy camels carrying us through the challenging terrain of this disorder. They also found that lithium, olanzapine, and aripiprazole were particularly effective in preventing manic episodes, while valproate, lamotrigine, and imipramine helped with depressive symptoms. However, they cautioned about the limited evidence supporting combination therapy, reminding us that sometimes, less is more.

The Importance of Individualized Treatment

The study highlighted the significance of personalized treatment strategies. The effectiveness of olanzapine and aripiprazole was observed in specific populations, emphasizing the need to tailor medication choices to each individual's unique needs and characteristics.

Navigating the Desert of Bipolar Disorder

This study sheds light on the importance of understanding and managing bipolar disorder. It stresses the necessity of working closely with a healthcare professional to find the most effective treatment approach. It's like navigating a desert – a compass, a reliable guide, and a well-stocked camel are essential for a successful journey.

Dr.Camel's Conclusion

This research provides a valuable roadmap for clinicians navigating the desert of bipolar disorder. The findings emphasize the importance of individualized treatment and the effectiveness of specific medications in preventing relapse. It's a reminder that we must approach bipolar disorder with both compassion and a scientific approach, providing effective treatment that allows individuals to thrive in their own unique ways.

Date :
  1. Date Completed 2009-09-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18635701

DOI: Digital Object Identifier

10.1177/0269881108093885

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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