Paper Details

  1. Home
  2. Paper Details

Regional chemotherapy for liver-limited metastatic colorectal cancer.

Author: Healey-BirdBrian R, KemenyNancy E, PowerDerek G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines the development and use of hepatic arterial infusion (HAI) of chemotherapy for liver metastases. HAI delivers high drug levels directly to the tumor, offering potential for resection and cure in select patients. Common HAI agents include floxuridine, oxaliplatin, and mitomycin-C. HAI can be used in palliative, neoadjuvant, and adjuvant settings. The review discusses HAI combinations, newer agents, and the potential for minimizing systemic side effects. Catheter-related complications and ulcers are the main toxicities.
Paper Details　
Original Abstract of the Article :
This review examines the development of hepatic arterial infusion (HAI) of chemotherapy over the past 40 years. Liver metastases are mainly supplied by the hepatic artery, and high levels of intratumoral drug delivery are achievable with the use of HAI. Floxuridine, 5-fluorodeoxyuridine is commonly ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3816/CCC.2008.n.032

データ提供：米国国立医学図書館（NLM）

Regional Chemotherapy for Liver-Limited Metastatic Colorectal Cancer: A Targeted Approach

This study explores the use of hepatic arterial infusion (HAI) chemotherapy, a targeted approach to delivering cancer treatment directly to the liver, for treating patients with liver-limited metastatic colorectal cancer. The researchers highlight the advantages of HAI, which allows for high levels of drug delivery to the tumor while minimizing systemic side effects. The study reviews the effectiveness of HAI in various settings, including palliative, neoadjuvant, and adjuvant therapy.

A Precision Approach to Cancer Treatment

HAI chemotherapy is like using a precise irrigation system to deliver water directly to the roots of a plant, maximizing the benefits and minimizing waste. This targeted approach allows for higher drug concentrations in the tumor, potentially leading to improved treatment outcomes and reduced side effects. This research highlights the potential of HAI for treating liver-limited metastatic colorectal cancer, offering a more focused and effective approach to combatting the disease.

Optimizing Treatment Strategies

This study underscores the importance of utilizing tailored treatment strategies for cancer, taking into account the specific location and characteristics of the disease. It highlights the potential of regional chemotherapy, such as HAI, to deliver drugs directly to the tumor, potentially improving treatment outcomes and reducing side effects. This is like using a caravan route specifically designed for a particular destination, minimizing the risks and maximizing the efficiency of the journey. This research emphasizes the need for ongoing research and development of innovative treatment strategies to improve the lives of cancer patients.

Dr.Camel's Conclusion

This research, like a well-equipped caravan traversing a vast desert, explores the potential of regional chemotherapy for treating liver-limited metastatic colorectal cancer. The researchers highlight the advantages of HAI, which allows for targeted drug delivery, minimizing systemic side effects and potentially improving treatment outcomes. This study emphasizes the importance of tailored treatment strategies, ensuring that we are using the most effective approach to combat this challenging disease.

Date :
  1. Date Completed 2008-10-09
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18650193

DOI: Digital Object Identifier

10.3816/CCC.2008.n.032

Related Literature

Article Analysis
・Side Effects of floxuridine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.