Paper Details 
Original Abstract of the Article :
St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal antidepressants for the treatment of minor to moderate depression. A major safety concern about SJW is its ability to alter the pharmacokinetics and/or clinical response of a variety of clinically important drugs tha...See full text at original site
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引用元:
https://doi.org/10.2174/138161208784746798

データ提供:米国国立医学図書館(NLM)

St. John's Wort: A Double-Edged Sword in the Desert of Drug Interactions

St. John's wort, a popular herbal remedy for mild to moderate depression, has gained widespread use. However, its potential for drug interactions raises a critical question: Can this natural remedy safely coexist with other medications? This research explores the complex interplay between St. John's wort and a wide range of conventional drugs, including anticancer, anti-HIV, anti-inflammatory, antimicrobial, cardiovascular, central nervous system, hypoglycemic, immuno-modulating, oral contraceptive, proton pump inhibitor, respiratory, and statin medications.

Imagine a bustling marketplace in a desert oasis, where traders from different regions converge. This research, like a cautious traveler navigating this marketplace, aims to understand how the introduction of St. John's wort might impact the interactions between various medications.

A Complex Web of Interactions

This research identifies numerous interactions between St. John's wort and conventional drugs, highlighting the potential for both pharmacokinetic and pharmacodynamic changes. St. John's wort can induce the production of certain enzymes involved in drug metabolism, leading to alterations in drug levels and effectiveness. This emphasizes the importance of consulting a healthcare professional before using St. John's wort, particularly when already taking other medications.

Navigating the Desert of Medication Interactions

This study, like a signpost in the desert of drug interactions, provides crucial information for both healthcare providers and patients. It encourages a proactive approach to medication management, particularly when considering the use of herbal remedies like St. John's wort. Always consult your healthcare provider before introducing new medications, including herbal supplements, to your routine.

Dr.Camel's Conclusion

This research, like a vigilant camel crossing a vast desert landscape, emphasizes the importance of careful consideration when combining St. John's wort with other medications. It serves as a reminder that even seemingly natural remedies can have significant interactions with other drugs, potentially affecting their effectiveness and safety.

Date :
  1. Date Completed 2008-10-06
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

18673195

DOI: Digital Object Identifier

10.2174/138161208784746798

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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