Side Effects of st. john's wort and depression: A Synthesis of Findings from 7 Studies

  1. Home
  2. Side Effects of st. john's wort and depression
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of st. john's wort and depression: A Synthesis of Findings from 7 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of st. john's wort and depression: A Synthesis of Findings from 7 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

St. John's Wort is a herbal antidepressant that has been used for centuries. Many studies have shown that St. John's Wort is more effective than placebo and is as effective as synthetic antidepressants for treating mild to moderate depression. 4 、、、 St. John's Wort also has a favorable side effect profile, leading to lower rates of dropouts. 4 However, there are some concerns about the safety of St. John's Wort, particularly its potential to interact with other medications. 3 、、

Reasons for Side Effects

St. John's Wort can induce cytochrome P450, an enzyme in the liver, which can alter the metabolism of other drugs and cause side effects. 3 、

Common Side Effects

Gastrointestinal

Taking St. John's Wort can cause gastrointestinal problems. 、

Skin

Taking St. John's Wort can cause photosensitivity. Use sunscreen and avoid sun exposure when outdoors.

Psychoneurological

Taking St. John's Wort can cause psychoneurological problems such as anxiety, excitement, and insomnia. 、

Other

Taking St. John's Wort can cause side effects such as fatigue, dizziness, nausea, and headache. 、 St. John's Wort can also interact with other medications. 3 、、 It is important to talk to your doctor before taking St. John's Wort.

Managing Side Effects

Gastrointestinal

If you experience gastrointestinal problems, talk to your doctor. Your doctor may recommend that you stop taking St. John's Wort or prescribe a different medication.

Skin

If you experience photosensitivity, talk to your doctor. Your doctor may recommend that you use sunscreen or prescribe a different medication.

Psychoneurological

If you experience psychoneurological problems, talk to your doctor. Your doctor may recommend that you stop taking St. John's Wort or prescribe a different medication.

Other

If you experience any other side effects, talk to your doctor. Your doctor may recommend that you stop taking St. John's Wort or prescribe a different medication.

Comparison Across Studies

Similarities Across Studies

Many studies have shown that St. John's Wort is more effective than placebo and is as effective as synthetic antidepressants for treating mild to moderate depression. 4 、、、

Differences Across Studies

Some studies have shown that St. John's Wort is more effective than synthetic antidepressants. 4 Other studies have shown that St. John's Wort is as effective as synthetic antidepressants. Some studies have shown that St. John's Wort has fewer side effects than synthetic antidepressants. 、

Points to Note for Real-World Application

St. John's Wort may be effective for treating mild to moderate depression. 4 、、 7 However, St. John's Wort can interact with other medications. 3 、、 It is important to talk to your doctor before taking St. John's Wort.

Limitations of Current Research

More research is needed on the side effects of St. John's Wort. 3 、、 Furthermore, more research is needed to understand how St. John's Wort interacts with other medications. 3 In addition, data on the long-term safety of St. John's Wort is insufficient. 3

Future Research Directions

More research is needed on the side effects of St. John's Wort. 3 、、 Furthermore, more research is needed to understand how St. John's Wort interacts with other medications. 3 In addition, data on the long-term safety of St. John's Wort is needed. 3

Conclusion

St. John's Wort may be a helpful option for treating mild to moderate depression. 4 、、 7 However, it is important to talk to your doctor before taking St. John's Wort, as it can interact with other medications. 3 、、 It is also important to be aware of the potential side effects, such as gastrointestinal problems, photosensitivity, and psychoneurological issues. 、

Literature analysis of 7 papers
Positive Content
6
Neutral Content
0
Negative Content
1
Article Type
0
2
3
4
7
1.

Post marketing new adverse effects of oral therapies in multiple sclerosis: A systematic review.

Author: SahraianMohammad Ali, SalehiAmir Mohammad, JenabiEnsiyeh, EsfahaniMaryam Etminani, AtaeiSara

Post-marketing side effects of DMDs for MS

While medications called disease-modifying drugs (DMDs) are used to manage multiple sclerosis (MS), there isn't enough information about the side effects that may occur after they are released to the market. This review aimed to identify the DMDs used for MS and to highlight the need for more research on their safety profile.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Systematic overview of drug interactions with antidepressant medications.

Author: NieuwstratenCarmine, LabirisN Renee, HolbrookAnne

Drug interactions

Drug interactions with antidepressants are a cause for concern, but the evidence is largely poor. Caution is recommended when combining antidepressants with other central nervous system (CNS) drugs, particularly when coadministering MAOIs with other substances.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Hypericum perforatum L. preparations for menopause: a meta-analysis of efficacy and safety.

Author: LiuY-R, JiangY-L, HuangR-Q, YangJ-Y, XiaoB-K, DongJ-X

Effective for menopause
Few side effects
Adverse events

A meta-analysis of 14 studies found that extracts of Hypericum perforatum L. (St. John’s Wort) were significantly more effective than placebo in treating menopausal symptoms. Hypericum perforatum L. was also associated with fewer side effects than placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

St John's wort for major depression.

Author: LindeKlaus, BernerMichael M, KristonLevente

Effective treatment
Fewer side effects

Hypericum extracts are superior to placebo and similarly effective as standard antidepressants in treating major depression, with fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.