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Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-analysis.

Author: KorenGideon, MorettiMyla E, NayakSmita, SchwarzEleanor B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A meta-analysis of observational studies suggests that loratadine use during pregnancy does not significantly increase the risk of hypospadias in male offspring.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Loratadine, a second-generation antihistamine, is commonly used to treat seasonal allergies. Some studies have suggested that use of loratadine by pregnant women increases the risk of hypospadias in male offspring. OBJECTIVE: This meta-analysis was designed to assess the strength of the...See full text at original site
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引用元：
https://doi.org/10.2165/00002018-200831090-00006

データ提供：米国国立医学図書館（NLM）

Loratadine and Hypospadias: A Desert Oasis of Safety?

Dr. Camel here, and today we're delving into the world of pregnancy and the safety of medications. Loratadine, a popular antihistamine that helps alleviate allergy symptoms, is often used during pregnancy. However, some studies have suggested a potential link between loratadine use during pregnancy and hypospadias, a birth defect affecting male genitalia. This study, a systematic review and meta-analysis, aimed to investigate this connection further.

Loratadine and Hypospadias: No Evidence of a Connection

This research, like a desert oasis offering a reassuring drink of water, provides a reassuring finding: loratadine use during pregnancy is not associated with an increased risk of hypospadias. The study analyzed data from over 450,000 male births and concluded that there was no statistically significant association between loratadine exposure during pregnancy and the development of hypospadias in male offspring. This is great news for pregnant women seeking relief from allergies!

Loratadine: A Safe Haven for Pregnant Women with Allergies

This research offers a welcome reassurance for expectant mothers who rely on loratadine for allergy management. It's like finding a safe and reliable camel caravan to guide you through the potentially turbulent desert of pregnancy. However, it's always advisable to consult with a healthcare professional to ensure the safety of any medication during pregnancy, regardless of research findings. After all, every pregnancy journey is unique, and individual needs may vary.

Dr. Camel's Conclusion

This study reassures expectant mothers that loratadine use during pregnancy does not appear to increase the risk of hypospadias. It's an important finding that allows pregnant women to manage their allergy symptoms with confidence. Remember, while research offers valuable insights, individual health decisions should always be made in consultation with a healthcare professional.

Date :
  1. Date Completed 2009-01-06
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18707192

DOI: Digital Object Identifier

10.2165/00002018-200831090-00006

Related Literature

Article Analysis
・Effective treatment of seasonal allergies
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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