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Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial).

Author: BemelmanWillem A, BilgenErnst Jan Spillenaar, BleichrodtRobert, BolwerkClemens J M, BoomMaarten J, BossuytPatrick M M, BrinkMenno A, BruinKarien F, CahenDjuna L, CenseHuib A, ConstenEsther C J, CrollaRogier M P H, DavidsPaul H P, DekkersPascal E P, EijsboutsQuirijn A, EshuisEmma J, GerhardsMichael F, GoeiT Hauwy, HoubenMartin H M G, JansenJeroen M, LangeJohan, LieverseRob J, MallantRosalie C, MarinelliAndreas W K S, MaringJohn K, MarsmanWillem A, OldenburgBas, OostenbrugLiekele E, PierikRobert E G J M, PrinsHubert A, SlotWarner Bruins, SosefMeindert N, SpanierB W Marcel, SprangersMirjam A G, StassenLaurents P S, StockmannHenricus B, StokkersPieter C F, VechtJuda, VoorburgAnnet M C J, de JongDirk J, van BerkelAnne-Marie, van BodegravenAd A, van DitzhuijsenTheo J M, van GelovenAnna A W, van HeukelemHenk A, van HillegersbergRichard, van Milligen de WitA W Marc, van OoteghemNancy A M, van WagensveldBart, van de LaarArnold, van den BrandeJan M H, van der PeetDonald L, van der WerfSjoerd D J, van der WoudeC Janneke, van der ZaagEdwin S

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compares two treatments for recurrent Crohn's disease in the lower part of the small intestine: 1) infliximab (a medication that targets inflammation) and 2) laparoscopic ileocolic resection (surgical removal of the affected portion of the intestine). The study aims to assess the impact of both approaches on quality of life and treatment costs, considering that infliximab is expensive and its long-term use is uncertain.
Paper Details　
Original Abstract of the Article :
With the availability of infliximab, nowadays recurrent Crohn's disease, defined as disease refractory to immunomodulatory agents that has been treated with steroids, is generally treated with infliximab. Infliximab is an effective but expensive treatment and once started it is unclear when therapy ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533646/

データ提供：米国国立医学図書館（NLM）

Crohn's Disease Treatment: A Tale of Two Options

This research delves into the world of gastroenterology, exploring the debate between laparoscopic ileocolic resection and infliximab treatment for managing recurrent Crohn's disease. It's like navigating a vast desert, where clinicians seek the most effective path to treating this challenging condition. The study, aptly named the LIR!C-trial, compared these two approaches, offering a detailed comparison of their effectiveness, quality of life impact, and cost implications. The researchers, like skilled explorers, carefully analyzed the results, seeking to provide clinicians with valuable insights to guide their treatment decisions.

A Crossroads in Crohn's Disease Treatment

This study provides valuable insights into the effectiveness, quality of life impact, and cost implications of both laparoscopic ileocolic resection and infliximab treatment for recurrent Crohn's disease. It's as if the researchers have erected two signposts in the desert, guiding clinicians towards the most appropriate treatment path for each patient.

Finding the Right Oasis for Crohn's Disease

This study emphasizes the importance of individualizing treatment decisions for patients with recurrent Crohn's disease. It's as if we are seeking the right oasis in the desert, where each patient can find the treatment that best suits their individual needs and circumstances.

Dr.Camel's Conclusion

This research offers a valuable roadmap for clinicians navigating the complex world of Crohn's disease treatment. By comparing laparoscopic ileocolic resection and infliximab treatment, the study highlights the importance of personalized treatment approaches and the need for careful consideration of each patient's unique needs and circumstances.

Date :
  1. Date Completed 2008-09-22
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18721465

DOI: Digital Object Identifier

PMC2533646

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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