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Efficacy and tolerability of salmeterol/fluticasone propionate versus montelukast in childhood asthma: A prospective, randomized, double-blind, double-dummy, parallel-group study.

Author: AndertonSally, ChanRobert, CuevasFrancisco, GuerraFrances, GutierrezJose Pablo, MasperoJorge, MechaliDaniel, PedersenSøren, Soto-RamosMario

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

In children with uncontrolled asthma previously on short-acting beta(2)-agonist monotherapy, inhaled salmeterol/fluticasone propionate (SFC) was significantly more effective in improving asthma control and decreasing exacerbation rates than oral montelukast (MON). Both drugs were well tolerated.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Asthma control remains suboptimal in adults and children worldwide. Inhaled salmeterol/fluticasone propionate combination (SFC) and oral montelukast (MON) are 2 treatments available for childhood asthma. OBJECTIVE: This study, the PEdiatric Asthma Control Evaluation (PEACE), investigate...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinthera.2008.07.018

データ提供：米国国立医学図書館（NLM）

A Battle of Two Therapies: Salmeterol/Fluticasone Propionate vs. Montelukast for Asthma

This study delves into the [world of childhood asthma], comparing the [effectiveness of two common treatments]: [salmeterol/fluticasone propionate (SFC)] and [montelukast (MON)]. The researchers [conducted a prospective, randomized, double-blind, double-dummy, parallel-group study] to evaluate the [efficacy and tolerability] of these medications in [managing persistent asthma] in children.

SFC emerges as a Superior Treatment for Childhood Asthma

The study found that [SFC] [significantly improved lung function] and [reduced asthma symptoms] compared to MON. The findings [demonstrate the superiority of SFC] in [controlling persistent asthma] in children. This research is like a [desert oasis], offering a [more effective treatment option] for children struggling with asthma.

Navigating the Path to Better Asthma Management

This study [provides valuable insights] for [clinicians managing childhood asthma]. The findings [highlight the importance of selecting] [appropriate treatment] based on [individual patient needs]. This research is like a [desert guide], [leading the way] towards [more effective and personalized asthma management].

Dr.Camel's Conclusion

This study [underscores the importance of considering treatment options] that [optimize asthma control] in children. The findings [demonstrate the efficacy of SFC] in [improving lung function and reducing asthma symptoms] compared to MON. This research is like a [desert expedition], [revealing new insights] into [the management of childhood asthma] and [leading us towards better treatment strategies].

Date :
  1. Date Completed 2008-10-20
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

18803991

DOI: Digital Object Identifier

10.1016/j.clinthera.2008.07.018

Related Literature

Article Analysis
・Effective treatment of asthma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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