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Effects of a new effervescent cimetidine formulation on gastric acidity in healthy subjects.

Author: BreumelhofR, FellingerH W, SmoutA J, VlasblomV

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A new effervescent formulation of 800 mg cimetidine was more effective than a standard dose of Maalox in increasing intragastric pH and prolonging the effect for the entire 5-hour study period.
Paper Details　
Original Abstract of the Article :
The effect of a new effervescent formulation of 800 mg cimetidine on intragastric acidity was studied in 10 fasting healthy male volunteers. Using a randomised, cross-over design, the effect of this new cimetidine formulation was compared with that of a standard dose of a liquid aluminium/magnesium ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1881502

データ提供：米国国立医学図書館（NLM）

A New Approach to Gastric Acidity: Effervescent Cimetidine

This study examines the effectiveness of a [new effervescent formulation of cimetidine], a medication commonly used to reduce gastric acidity. The research [employed a randomized, crossover design] to compare the efficacy of this formulation with a standard antacid. The study's objective was to assess the impact of the new formulation on intragastric pH levels.

Prolonged Relief: The Advantage of Effervescent Cimetidine

The study found that [effervescent cimetidine] significantly [increased intragastric pH] compared to the standard antacid, and this effect [persisted for a longer duration]. The results [demonstrate the advantages of the new formulation]. The researchers likened the effect of the new formulation to a [cool desert breeze], providing sustained relief from gastric discomfort.

A Promising Combination for Gastric Health

This research suggests that the [new cimetidine formulation] offers a promising [combination of immediate and prolonged effects]. The study provides valuable insights for [understanding the efficacy of different medications for managing gastric acidity]. It's like a [treasure map], leading us towards better treatment strategies for common gastric discomforts.

Dr.Camel's Conclusion

This research is a [compelling exploration] of the potential of a new cimetidine formulation. It highlights the [importance of optimizing treatment] for gastric acidity by considering both immediate and long-term effects. The results are like a [fresh spring], providing a new perspective on managing this prevalent issue.

Date :
  1. Date Completed 1991-10-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1881502

DOI: Digital Object Identifier

1881502

Related Literature

Article Analysis
・Effects of cimetidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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