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Efficacy of biologicals in the treatment of rheumatoid arthritis. a meta-analysis.

Author: MalhotraS, PandhiP, SidhuS, VenkateshanS P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Rheumatoid arthritis (RA) is a chronic disease affecting joints. Women are three times more likely to have RA than men. Early treatment with disease-modifying drugs is crucial to prevent joint damage. Newer medications include methotrexate, sulfasalazine, hydroxychloroquine, leflunomide, and cyclosporine. Recent advances include biological agents that target specific molecules involved in RA. This review of 26 studies found that these biological agents were significantly more effective than placebo at all time points and for all levels of improvement. These medications were effective for both people who had never received treatment and those who hadn't responded to methotrexate. Overall, these biological agents are very effective in treating RA.
Paper Details　
Original Abstract of the Article :
Rheumatoid arthritis (RA) is a chronic multisystem disease. A characteristic feature of RA is persistent inflammatory synovitis, usually involving the peripheral joints in a symmetric distribution. The prevalence of RA is approximately 0.8% of the population (range: 0.3-2.1%); women are affected app...See full text at original site
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引用元：
https://doi.org/10.1159/000165777

データ提供：米国国立医学図書館（NLM）

Biologicals: A Powerful Weapon Against Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints, causing pain, stiffness, and swelling. Finding effective treatments for RA is like searching for a cool spring in a scorching desert. This study delves into the efficacy of biological agents, a newer class of medications, in treating refractory RA.

The researchers conducted a meta-analysis of 26 studies, pooling data on the effectiveness of various biological agents compared to placebo. They measured the effectiveness based on the American College of Rheumatology (ACR) response criteria, which assess improvements in symptoms and function.

Biologicals: A Winning Formula?

The results of this meta-analysis were quite encouraging. The pooled odds ratios for ACR response criteria were significantly higher for patients receiving biologicals compared to placebo, indicating a clear benefit in treating RA. This suggests that biologicals can be an effective treatment option, particularly for patients who have not responded to traditional medications.

Finding Relief in the Desert of Pain

This study provides hope for individuals suffering from RA, suggesting that biologicals can offer substantial relief from symptoms and potentially improve quality of life. However, it’s important to remember that biologicals are not a cure for RA and may have potential side effects. Consulting with a healthcare professional to discuss the risks and benefits of these medications is crucial.

Dr.Camel's Conclusion

This study highlights the potential of biological agents as effective treatment options for RA, offering a glimmer of hope in the desert of pain. However, as with any treatment, careful consideration of individual needs and potential side effects is essential.

Date :
  1. Date Completed 2009-02-06
  2. Date Revised 2008-12-18
Further Info :

Pubmed ID

18957873

DOI: Digital Object Identifier

10.1159/000165777

Related Literature

Article Analysis
・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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