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Alpha-Tocopherol counteracts ritonavir-induced proinflammatory cytokines expression in differentiated THP-1 cells.

Author: AzziAngelo, GuoWeimin, MeydaniMohsen, ZinggJean Marc

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study investigates the effect of ritonavir, an HIV protease inhibitor, on proinflammatory cytokine synthesis in THP-1/macrophages. The results show that ritonavir significantly increases the expression of proinflammatory cytokines, IL-6, MCP-1, and IL-8, at both mRNA and protein levels. This effect is suppressed by alpha-tocopherol supplementation. The findings suggest that ritonavir-induced proinflammatory cytokine synthesis may contribute to premature atherosclerosis in ritonavir-treated patients and that alpha-T may prevent this effect.
Paper Details　
Original Abstract of the Article :
Treatment of HIV-infected individuals with HIV protease inhibitor (HPI) drugs has significantly increased their life span. However, one of the side effects of HPI drugs is the development of premature atherosclerosis, whose molecular pathogenesis remains unclear. Previously we have reported that alp...See full text at original site
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引用元：
https://doi.org/10.1002/biof.5520310304

データ提供：米国国立医学図書館（NLM）

Alpha-Tocopherol: A Potential Shield Against Ritonavir-Induced Inflammation

This research explores the potential protective effects of alpha-tocopherol, a form of vitamin E, against the proinflammatory effects of ritonavir, a widely used HIV protease inhibitor. Ritonavir, while highly effective in treating HIV infection, is associated with premature atherosclerosis, a condition characterized by hardening and narrowing of arteries. The study investigates the hypothesis that ritonavir increases the production of proinflammatory cytokines, contributing to atherosclerosis, and that alpha-tocopherol supplementation can counteract this effect. The researchers found that ritonavir treatment significantly increased the expression of proinflammatory cytokines (IL-6, MCP-1, and IL-8) in differentiated THP-1 cells, a model of human macrophages. However, treatment with alpha-tocopherol effectively suppressed the ritonavir-induced increase in proinflammatory cytokines.

Alpha-Tocopherol: A Potential Ally in HIV Treatment

This study suggests that alpha-tocopherol supplementation may offer a protective effect against the proinflammatory effects of ritonavir, potentially mitigating the risk of premature atherosclerosis in HIV-infected individuals. The study's findings highlight the importance of exploring dietary and nutritional interventions to address the long-term health consequences of HIV treatment.

Understanding the Complexity of HIV Treatment

This study reminds us that the treatment of chronic diseases is a complex process that requires careful consideration of both the benefits and potential risks of medications. The study suggests that understanding the interactions between drugs and the body, including the role of dietary factors, is crucial for optimizing treatment outcomes and minimizing long-term health complications.

Dr.Camel's Conclusion

This research offers valuable insights into the potential benefits of alpha-tocopherol supplementation in mitigating the inflammatory effects of ritonavir. The study highlights the importance of exploring nutritional interventions to enhance the safety and efficacy of HIV treatment. As a researcher, I believe that continued exploration of these complex interactions between drugs, dietary factors, and the human body is essential for improving the lives of individuals living with chronic diseases.

Date :
  1. Date Completed 2009-01-12
  2. Date Revised 2019-10-27
Further Info :

Pubmed ID

18997280

DOI: Digital Object Identifier

10.1002/biof.5520310304

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in preparation
Languages

English

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