Paper Details

  1. Home
  2. Paper Details

Tarenflurbil protection from cytotoxicity is associated with an upregulation of neurotrophins.

Author: AndrewsPeter M, HoeHyang-Sook, RebeckG William, ZhaoXu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tarenflurbil, an R-flurbiprofen derivative, has been reported to lower amyloid-beta 42 (Abeta_{42}) levels in Alzheimer's disease (AD). This study shows that clinically relevant concentrations of tarenflurbil protect human neuroblastoma cell lines and primary neurons from Abeta_{42} and H_{2}O_{2} cytotoxicity. This protective effect is associated with an upregulation of neurotrophins, suggesting a potential mechanism for tarenflurbil's beneficial effects in AD.
Paper Details　
Original Abstract of the Article :
Both epidemiological and clinical trial data have demonstrated the value of some non-steroidal anti-inflammatory drugs (NSAIDs) and NSAID derivatives for lowering the incidence, slowing the progression, and reducing the symptomatic severity of Alzheimer's disease (AD). Tarenflurbil (R-flurbiprofen, ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3233/jad-2008-15306

データ提供：米国国立医学図書館（NLM）

Tarenflurbil: A Neuroprotective Agent for Alzheimer's Disease

This research examines the potential benefits of [tarenflurbil] in mitigating the effects of [Alzheimer's disease (AD)]. The researchers found that [tarenflurbil] protected [cultured human neuroblastoma cell lines and primary neurons] from cytotoxicity associated with exposure to [amyloid-beta 42 (Abeta_{42}) or H_{2}O_{2}]. This neuroprotective effect was linked to an upregulation of [neurotrophins] such as [nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)].

Unveiling the Neuroprotective Mechanisms of Tarenflurbil

This study provides compelling evidence that [tarenflurbil] might offer neuroprotective benefits in the context of [AD]. The upregulation of [neurotrophins] suggests a potential mechanism by which [tarenflurbil] might exert its protective effects.

Harnessing the Power of Neurotrophins for Brain Health

These findings underscore the crucial role of [neurotrophins] in maintaining brain health, particularly in the context of [AD]. The research highlights the potential for [tarenflurbil] to stimulate the production of [neurotrophins], offering a potential avenue for therapeutic intervention in [AD].

Dr.Camel's Conclusion

This study delves into the intricate world of [AD], exploring the potential of [tarenflurbil] as a neuroprotective agent. Like a desert flower blooming amidst harsh conditions, [tarenflurbil] shows promise in promoting brain health, offering a glimmer of hope in the fight against [AD].

Date :
  1. Date Completed 2009-01-06
  2. Date Revised 2019-11-11
Further Info :

Pubmed ID

18997293

DOI: Digital Object Identifier

10.3233/jad-2008-15306

Related Literature

Article Analysis
・Side Effects of flurbiprofen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.