Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studies.

Author: CheyW D, DrossmanD A, FassR, JohansonJ F, PanasR, ScottC, UenoR

Paper Details 
Original Abstract of the Article :
BACKGROUND: Effective treatments for irritable bowel syndrome with constipation (IBS-C) are lacking. AIM: To assess the efficacy and safety of lubiprostone in IBS-C. METHODS: A combined analysis was performed among 1171 patients with a Rome II diagnosis of IBS-C in two phase-3 randomized trials of...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2036.2008.03881.x

データ提供:米国国立医学図書館(NLM)

Lubiprostone: A Promising Treatment for Irritable Bowel Syndrome with Constipation

Irritable bowel syndrome with constipation (IBS-C) is a common digestive disorder that can significantly affect quality of life. This research explores the effectiveness of lubiprostone, a medication that stimulates intestinal fluid secretion, in treating IBS-C. Researchers combined data from two phase-3 randomized clinical trials to evaluate the efficacy and safety of lubiprostone compared to a placebo.

Easing IBS-C Symptoms: Lubiprostone's Potential Benefits

The study found that lubiprostone significantly improved the percentage of overall responders, meaning a higher proportion of patients reported significant relief from their IBS-C symptoms compared to those taking a placebo. Lubiprostone was also well-tolerated, with a favorable safety profile. These findings suggest that lubiprostone could be a valuable treatment option for individuals struggling with IBS-C.

Navigating IBS-C: Finding the Right Treatment Approach

This research offers hope for individuals seeking relief from IBS-C. While lubiprostone appears to be a promising treatment option, it's crucial to consult with a healthcare professional to determine the best course of action. Just as a desert traveler relies on a reliable guide, seeking professional guidance can help you find the right path to managing IBS-C symptoms and improving your digestive health.

Dr.Camel's Conclusion

This research provides valuable insights into the potential of lubiprostone for treating IBS-C. The findings suggest that lubiprostone could be a valuable addition to the therapeutic arsenal for individuals experiencing this debilitating disorder. This research, like a refreshing oasis in the challenging desert of IBS-C, offers hope for a more comfortable and manageable future for affected individuals.

Date :
  1. Date Completed 2009-04-02
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

19006537

DOI: Digital Object Identifier

10.1111/j.1365-2036.2008.03881.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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