Effective treatment of irritable bowel syndrome: A Synthesis of Findings from 104 Studies

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Original Abstract of the Article

Major Research Findings

Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder characterized by abdominal pain, bloating, and changes in bowel habits. 95 , 3 , 71 . It significantly affects the quality of life, impacts work productivity, and increases healthcare costs. 95 , 3 , 71 . There is no established cure for IBS, and treatment often involves empirical approaches to manage symptoms. 95 .

Research has investigated various treatments for IBS. Psychological treatment combining psychotherapy, relaxation, and standard medical care has shown greater improvement in diarrhea and abdominal pain compared to standard medical care alone. 3 . Novel medications like tegaserod have also been reported to be effective in improving IBS symptoms. 28 , 29 .

In recent years, the role of gut microbiota abnormalities in IBS has gained attention, leading to research on treatments like probiotics, prebiotics, and fecal microbiota transplantation. 72 , 84 , 55 , 104 .

Dietary interventions have also emerged as promising approaches for IBS symptom management, with the low FODMAP diet gaining prominence. 71 , 73 . This diet restricts certain carbohydrates that are poorly absorbed in the small intestine and subsequently fermented in the colon, potentially reducing abdominal pain and bloating. 71 .

Other treatments under investigation include traditional Chinese medicine, acupuncture, and hypnotherapy. 19 , 58 , 44 .

Treatment Summary

Various treatment approaches are being explored, including psychological treatment combining psychotherapy, relaxation, and standard medical care, medications like tegaserod, probiotics, prebiotics, fecal microbiota transplantation, low FODMAP diets, traditional Chinese medicine, acupuncture, and hypnotherapy.

Benefits and Risks

Benefit Summary

Various IBS treatments have the potential to offer benefits such as symptom improvement, enhanced quality of life, reduced work impact, and lower healthcare costs. 3 , 28 , 29 , 72 , 84 , 55 , 104 , 71 , 73 , 19 , 58 , 44 .

Risk Summary

IBS treatments may carry the risk of side effects. For instance, medications can cause nausea, constipation, diarrhea, headaches, and other adverse reactions. 28 , 29 . Low FODMAP diets may pose a risk of nutritional deficiencies. 71 . Fecal microbiota transplantation carries a risk of infections. 104 .

Comparison of Studies

Commonalities

Many studies suggest the potential benefits of IBS treatments, including symptom improvement, enhanced quality of life, reduced work impact, and lower healthcare costs. 3 , 28 , 29 , 72 , 84 , 55 , 104 , 71 , 73 , 19 , 58 , 44 .

Differences

Variations in treatment methods and evaluation approaches across studies result in varying outcomes. For instance, psychological treatment efficacy may vary based on patient personality and symptom type. 3 . Drug effectiveness can differ depending on the type and dosage of medication. 28 , 29 .

Consistency and Contradictions in Results

Research on IBS treatments exhibits both consistent and contradictory findings. This can be attributed to the complex nature of IBS and significant variations in symptoms among patients. 3 , 71 .

Considerations for Real-World Application

IBS treatment should be personalized based on each patient's unique symptoms and lifestyle. 95 . Therefore, consulting with a physician and selecting an appropriate treatment plan are crucial before starting any therapy. 95 .

Limitations of Current Research

Research on IBS treatments still faces numerous challenges. For example, there is no established standard metric for evaluating treatment efficacy. Furthermore, data on long-term treatment effects and safety are limited. 3 , 71 .

Future Research Directions

Further research on IBS treatments is necessary in the following areas:

  • Establishing standard metrics for evaluating treatment efficacy
  • Assessing long-term treatment effects and safety
  • Investigating the relationship between gut microbiota abnormalities and IBS
  • Developing novel treatment approaches

Conclusion

IBS is a prevalent chronic gastrointestinal disorder that significantly impacts quality of life. 95 , 3 , 71 . While various treatments are being explored, no definitive cure has been established. 95 . If you are experiencing IBS symptoms, it is vital to consult a physician to discuss and select an appropriate treatment plan. 95 .

Treatment List

Psychological treatment, relaxation, standard medical care, medications like tegaserod, probiotics, prebiotics, fecal microbiota transplantation, low FODMAP diets, traditional Chinese medicine, acupuncture, hypnotherapy

Keywords
Benefit Keywords
Improved symptoms
1
Improved bowel symptoms
Improved psychological symptoms
2
Improved abdominal pain
Improved diarrhea
3
Initial improvement in symptoms
4
Improved irritable bowel syndrome symptoms
5
Improved irritable bowel syndrome symptoms
6
Accelerated gastric emptying
Delayed bowel transit
Improved IBS symptoms
Improved diarrhea symptoms
Less urgency
Reduced diarrhea
Reduced urgency
7
Improved irritable bowel syndrome symptoms
8
Improved irritable bowel syndrome symptoms
Reduced anxiety
Reduced depression
9
Improved irritable bowel syndrome symptoms
11
Psychological treatment for IBS
13
Bowel spasm relaxation
IBS symptom relief
Improved irritable bowel syndrome treatment
14
Therapeutic benefit for IBS
15
Improved stool passage
16
Improved irritable bowel syndrome treatment
17
Improved IBS motility
Improved irritable bowel syndrome treatment
Symptom relief
18
Global improvement
IBS symptom improvement
19
Effective for irritable bowel syndrome
Improved bowel function
20
Improved bowel function
Reduced pain
21
Diarrhea relief
Pain relief
22
Effective for IBS
IBS symptom relief
Potential for motility control
23
IBS symptom management
24
IBS symptom relief
25
IBS treatment
26
IBS symptom management
27
Reduced IBS symptoms
28
Improved IBS symptoms
29
IBS treatment
30
Alleviate IBS symptoms
31
Reduced symptom recurrence
32
IBS treatment
33
Reduced IBS symptoms
34
Improved quality of life
Relief of IBS symptoms
35
Improved therapeutic effect on IBS
38
Improvement in IBS symptoms
Well tolerated
39
Improved IBS treatment
40
Improved IBS treatment
41
IBS symptom improvement
42
Improved IBS treatment
43
Effective for IBS symptoms
44
Improved quality of life
Reduced IBS symptoms
45
Improved IBS pain
Improved IBS symptoms
Increased pain free days
Reduced pain scores
46
Improved IBS treatment
47
Improved IBS symptoms
48
Improved IBS-C symptoms
49
Improved IBS treatment
50
Improved quality of life
Symptom improvement
51
IBS symptom relief
Safe treatment
52
Improved IBS symptoms
53
IBS treatment
54
Abdominal pain relief
Bloating relief
IBS symptom relief
Stool consistency improvement
55
IBS treatment
56
Treatment of irritable bowel syndrome
57
Treatment of IBS
58
Reduced IBS
Reduced stress
59
Improved IBS symptoms
60
Treatment of PI-IBS
61
Improved GI function
Potential for IBS treatment
Treatment of IBS
62
Linaclotide improves IBS-C symptoms
63
IBS treatment
64
IBS treatment
65
Improved IBS symptoms
66
IBS treatment
67
Effective IBS treatment
68
IBS treatment
69
Probiotics efficacy
Symptom relief
70
IBS treatment
71
Clinical improvement
72
IBS and IBD treatment
73
Improved IBS symptoms
74
IBS treatment
75
IBS treatment
76
Effective IBS treatment
Improved quality of life
77
IBS treatment
78
IBS treatment
79
IBS-D treatment
80
Combined treatment approach
D-IBS treatment
Potential for IBS relief
81
Dietary intervention
IBS treatment
82
Exercise
IBS treatment
83
Gut microbiota
IBS treatment
84
CBT
IBS treatment
85
Improved IBS-D symptoms
86
IBS-D symptom improvement
Safe and effective
87
Enhanced quality of life
IBS treatment
Improved IBS symptoms
MegaSporeBiotic
Potential for gut microbiota modulation
88
Improved quality of life
Reduced IBS symptoms
89
Aloe vera efficacy
Asafoetida efficacy
IBS symptom relief
Peppermint oil efficacy
90
Improved visceral hypersensitivity
Reduced IBS symptoms
91
IBS-type symptoms
92
IBS treatment
93
IBS symptom improvement
94
Improved bloating
Superior to placebo
95
FMT for IBS
96
IBS management
eHealth interventions
97
Dietary treatment
IBS treatment
98
IBS treatment
99
IBS treatment
100
Improved microbiota
Reduced inflammation
101
Improved IBS-D symptoms
102
IBS treatment
103
IBS treatment
104
Risk Keywords
Large placebo effect
Limited benefit from medical treatment alone
2
Limited benefit for constipation
3
Chronic disease
Poor prognosis
4
Accelerated gastric emptying
Delayed bowel transit
7
Bran ineffective for IBS
10
None reported
21
Inconclusive evidence
22
Mechanism unknown
Unclear efficacy in short-term
Unclear efficacy on colonic transit time
Unclear short-term efficacy
23
No evidence for effectiveness
24
Management can be difficult
Need for further trials
Treatment unrewarding
27
Safe and well tolerated
28
Diarrhea
29
Uncertain benefits
30
Mild to moderate adverse events
32
Weak evidence for bulking agents
33
Ineffectiveness
34
Placebo effect
36
Ineffective treatment
37
Ischemic colitis
Severe constipation
39
Irritable bowel syndrome
40
Irritable bowel syndrome
41
Irritable bowel syndrome
43
Irritable bowel syndrome
47
Irritable bowel syndrome
50
Short-term effect
51
Dropout rate
59
No significant adverse effects
60
Limited evidence for IBS
Needs further research
Potential for side effects
62
None reported
72
Needs further research
Potential for interactions
Unclear synergistic effects
81
FODMAPs controversy
82
Limited comparison
Needs further research
Potential side effects
88
Lack of replication
Limited efficacy evidence
90
Drowsiness
Fatigue
91
FMT adverse effects
96
None
101
Literature analysis of 104 papers
Positive Content
96
Neutral Content
3
Negative Content
5
Article Type
66
21
34
28
104
1.

The value of prescribed 'high-fibre' diets for the treatment of the irritable bowel syndrome.

Author: LambertJ P, BruntP W, MowatN A, KhinC C, LaiC K, MorrisonV, DickersonJ W, EastwoodM A

Improved symptoms

A study of 72 patients with irritable bowel syndrome found that higher dietary fiber intake was associated with improved symptoms like constipation, urgency, and hard stools.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Behavioural psychotherapy in the treatment of irritable bowel syndrome.

Author: CorneyR H, StantonR, NewellR, ClareA, FaircloughP

Improved bowel symptoms
Improved psychological symptoms
Large placebo effect
Limited benefit from medical treatment alone

A study of 42 irritable bowel syndrome (IBS) patients compared medical treatment with behavioral psychotherapy. Both treatments led to general improvement in symptoms, but behavioral psychotherapy was more effective in reducing avoidance behaviors. Improvement in bowel symptoms was associated with improvement in psychological symptoms, highlighting the strong connection between these factors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

A controlled trial of psychological treatment for the irritable bowel syndrome.

Author: GuthrieE, CreedF, DawsonD, TomensonB

Improved abdominal pain
Improved diarrhea
Limited benefit for constipation

A study of 102 patients with irritable bowel syndrome who did not respond to standard treatment found that psychological treatment was effective in improving diarrhea and abdominal pain in two-thirds of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

[Prognosis of patients with irritable intestine syndrome. A prospective study with 1 year follow-up].

Author: Linares RodríguezA, Rodrigo SáezL, Pérez AlvarezR, Sánchez LombrañaJ L, Rodríguez PérezA, Arribas CastrilloJ M

Initial improvement in symptoms
Chronic disease
Poor prognosis

A study of 86 patients with irritable bowel syndrome found that although most patients initially improved with treatment, a significant proportion (61.6%) had the same or worse symptoms after one year. Patients with a good prognosis had more consistent medical adherence and prior periods without symptoms. Patients with a poor prognosis had higher anxiety and depression scores.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

5.

Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled crossover study.

Author: LuceyM R, ClarkM L, LowndesJ, DawsonA M

Improved irritable bowel syndrome symptoms

A study of 28 patients with irritable bowel syndrome found that bran biscuits did not provide any significant benefit compared to placebo biscuits, despite a placebo effect being observed in both groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Comparison of various treatments for irritable bowel syndrome.

Author: RitchieJ A, TrueloveS C

Improved irritable bowel syndrome symptoms

A study of 96 patients with irritable bowel syndrome found that a combination of ispaghula, Motival, and mebeverine was most effective in relieving symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Role of loperamide and placebo in management of irritable bowel syndrome (IBS).

Author: CannP A, ReadN W, HoldsworthC D, BarendsD

Accelerated gastric emptying
Delayed bowel transit
Improved IBS symptoms
Improved diarrhea symptoms
Less urgency
Reduced diarrhea
Reduced urgency
Accelerated gastric emptying
Delayed bowel transit

A study of 28 patients with irritable bowel syndrome found that loperamide was more effective than placebo in relieving symptoms, accelerating gastric emptying, and delaying intestinal transit.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Influence of drug treatment on the irritable bowel syndrome and its interaction with psychoneurotic morbidity.

Author: Lancaster-SmithM J, ProutB J, PintoT, AndersonJ A, SchiffA A

Improved irritable bowel syndrome symptoms

In a study of 60 people with irritable bowel syndrome (IBS), a combined anxiolytic/antidepressant medication (Motipress) was more effective than placebo in treating diarrhea and abdominal pain. While there was no direct relationship between mental health issues and IBS, the study suggests that mental health issues negatively impacted the short-term outcomes of the bowel disorder.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

A controlled comparison of cognitive therapy and self-help support groups in the treatment of irritable bowel syndrome.

Author: PayneA, BlanchardE B

Improved irritable bowel syndrome symptoms
Reduced anxiety
Reduced depression

A study of 34 patients with irritable bowel syndrome (IBS) compared individualized cognitive therapy (CT), self-help support group (SG), and a symptom-monitoring waiting list control (WL) group. After 8 weeks, the CT group showed significantly greater reductions in both gastrointestinal (GI) symptoms and overall GI symptom change compared to the SG and WL groups. The CT group also showed significant improvement in measures of depression and anxiety. At 3-month follow-up, the positive results for the CT group were maintained and showed further improvements. This suggests that individualized cognitive therapy may be more effective than self-help or no treatment for managing IBS symptoms and related psychological distress.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Bran supplementation in the treatment of irritable bowel syndrome.

Author: SnookJ, ShepherdH A

Bran ineffective for IBS

Dietary supplementation with bran fibre was not more effective than placebo in improving symptoms of irritable bowel syndrome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Cognitive therapy for irritable bowel syndrome.

Author: GreeneB, BlanchardE B

Improved irritable bowel syndrome symptoms

In a study of 20 people with irritable bowel syndrome (IBS), those who received cognitive therapy showed significantly greater improvement in their symptoms than those who just monitored their symptoms. At the end of treatment, 80% of the cognitive therapy group had significant improvement, compared to only 10% of the monitoring group. These improvements were maintained at a 3-month follow-up. The study also found that reductions in IBS symptoms correlated with positive changes in thoughts and a decrease in negative thoughts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial.

Author: AwadR, DibildoxM, OrtizF

Irritable bowel syndrome is a major cause of missed work. As there is currently no effective treatment, sufferers often seek help from multiple doctors and try various medications over long periods. This has significant economic and social implications for families and workplaces.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Psychological treatments for irritable bowel syndrome: a critique of controlled treatment trials.

Author: TalleyN J, OwenB K, BoyceP, PatersonK

Psychological treatment for IBS

The efficacy of psychological treatments for irritable bowel syndrome (IBS) remains uncertain due to methodological limitations in research.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome.

Author: EfskindP S, BernklevT, VatnM H

Bowel spasm relaxation
IBS symptom relief
Improved irritable bowel syndrome treatment

This study investigated the effects of loperamide on irritable bowel syndrome (IBS) symptoms. Previous studies showed that loperamide can relax spasms in the large intestine and improve symptoms of diarrhea. This study aimed to examine the effects of loperamide in a diverse group of people with IBS, acknowledging that IBS symptoms can be caused by different factors affecting bowel movement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Treatment of irritable bowel syndrome with Lacteol Fort: a randomized, double-blind, cross-over trial.

Author: HalpernG M, PrindivilleT, BlankenburgM, HsiaT, GershwinM E

Therapeutic benefit for IBS

Lacteol Fort, an antidiarrheal drug, demonstrated a statistically significant therapeutic benefit in 50% of patients with irritable bowel syndrome (IBS), improving symptoms such as abdominal pain, bloating, and stool frequency.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Double-blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome.

Author: SchützeK, BrandstätterG, DragosicsB, JudmaierG, HentschelE

Improved stool passage

Cisapride was not superior to placebo in treating constipation and abdominal discomfort in irritable bowel syndrome. However, it may improve the difficulty of stool passage.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Adequate relief as an endpoint in clinical trials in irritable bowel syndrome.

Author: MangelA W, HahnB A, HeathA T, NorthcuttA R, KongS, DukesG E, McSorleyD

Improved irritable bowel syndrome treatment

This study found that patients’ perception of adequate pain relief in irritable bowel syndrome (IBS) is a good indicator of overall improvement. In a study of 370 people with IBS, adequate pain relief was associated with a reduction in pain severity, fewer pain-free days, fewer days with urgency, improved bowel frequency and consistency, and better quality of life. This suggests that adequate pain relief can be used as a key measure of treatment effectiveness in IBS.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of cisapride on symptoms and postcibal small-bowel motor function in patients with irritable bowel syndrome.

Author: NoorN, SmallP K, LoudonM A, HauC, CampbellF C

Improved IBS motility
Improved irritable bowel syndrome treatment
Symptom relief

This study investigated the effects of long-term treatment with cisapride, a medication that speeds up digestion, on bowel movement and symptoms in patients with irritable bowel syndrome (IBS). The study focused on how cisapride affected the movement of the jejunum (a part of the small intestine) after eating.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Treatment of irritable bowel syndrome with Chinese herbal medicine: a randomized controlled trial.

Author: BensoussanA, TalleyN J, HingM, MenziesR, GuoA, NguM

Global improvement
IBS symptom improvement

Both individualized and standard Chinese herbal formulations demonstrated significant improvement in symptoms for patients with irritable bowel syndrome (IBS) compared to placebo. However, individualized formulations only maintained improvement at 14 weeks follow-up.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist.

Author: CamilleriM, MayerE A, DrossmanD A, HeathA, DukesG E, McSorleyD, KongS, MangelA W, NorthcuttA R

Effective for irritable bowel syndrome
Improved bowel function

Alosetron is effective in treating abdominal pain, discomfort, and bowel-related symptoms in female irritable bowel syndrome patients with predominant diarrhea or alternating constipation and diarrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome.

Author: BardhanK D, BodemarG, GeldofH, SchützE, HeathA, MillsJ G, JacquesL A

Improved bowel function
Reduced pain
None reported

Alosetron, a 5-HT3 receptor antagonist, was found to be effective in treating female patients with irritable bowel syndrome. The 2 mg b.d. dosage significantly increased the proportion of pain-free days and decreased the visual analogue scale score for diarrhea compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials.

Author: JailwalaJ, ImperialeT F, KroenkeK

Diarrhea relief
Pain relief
Inconclusive evidence

Smooth-muscle relaxants are beneficial for irritable bowel syndrome patients with abdominal pain as the predominant symptom. Loperamide is effective for diarrhea but does not relieve abdominal pain. More high-quality trials are needed to determine the efficacy of psychotropic agents, 5-HT-receptor antagonists, peppermint oil, and Chinese herbal medicine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Effect of a calcium channel blocker and antispasmodic in diarrhoea-predominant irritable bowel syndrome.

Author: LuC L, ChenC Y, ChangF Y, ChangS S, KangL J, LuR H, LeeS D

Effective for IBS
IBS symptom relief
Potential for motility control
Mechanism unknown
Unclear efficacy in short-term
Unclear efficacy on colonic transit time
Unclear short-term efficacy

Irritable bowel syndrome (IBS) is a disorder affecting the colon. Pinaverlum bromide and mebeverine are medications that have been shown to be effective in treating IBS for a longer period of time (12-16 weeks). This study investigates the effectiveness of these medications for short-term treatment of IBS and their impact on bowel movement speed. The study will also explore if these medications work by influencing specific chemicals in the gut (substance P and neuropeptide Y) that affect bowel movement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

A single-blind trial of reflexology for irritable bowel syndrome.

Author: ToveyPhilip

IBS symptom management
No evidence for effectiveness

Irritable bowel syndrome (IBS) is a common issue for primary care providers, as treatment options are limited and the condition often becomes chronic. People are increasingly seeking out complementary and alternative medicine, including reflexology, to manage symptoms. However, there is currently no research on the effectiveness of reflexology for IBS, despite its widespread use and advocacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

A systematic review of tegaserod for the treatment of irritable bowel syndrome.

Author: JonesB W, MooreD J, RobinsonS M, SongF

IBS symptom relief

Tegaserod may be an appropriate treatment for occasional use for relief of GI symptoms associated with constipation-predominant IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Systematic review: serotonergic modulators in the treatment of irritable bowel syndrome--influence on psychiatric and gastrointestinal symptoms.

Author: KilkensT O C, HonigA, RozendaalN, Van NieuwenhovenM A, BrummerR-J M

IBS treatment

Medications that affect serotonin, a brain chemical, are used to treat irritable bowel syndrome (IBS). Many people with IBS also experience mood problems. Serotonin may play a role in both digestive function and mood regulation in people with IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Safety and tolerability of tegaserod in irritable bowel syndrome management.

Author: BerardiRosemary R

Reduced IBS symptoms
Safe and well tolerated

Tegaserod is effective and safe for the treatment of irritable bowel syndrome (IBS) in women whose primary bowel symptom is constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Tegaserod for the treatment of irritable bowel syndrome.

Author: EvansB W, ClarkW K, MooreD J, WhorwellP J

Improved IBS symptoms
Diarrhea

Tegaserod, a 5HT(4) partial agonist, was shown to be more effective than placebo in improving global gastrointestinal (GI) symptoms in patients with constipation-predominant irritable bowel syndrome (IBS). The number needed to treat (NNT) was 17. Tegaserod did not significantly improve abdominal pain or discomfort, but it did improve bowel habit. Diarrhea was a common side effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome.

Author: BijkerkC J, MurisJ W M, KnottnerusJ A, HoesA W, de WitN J

IBS treatment
Uncertain benefits

High-fiber diets and fiber supplements are commonly recommended for irritable bowel syndrome (IBS). People with constipation-predominant IBS may have slower bowel movements, so fiber that speeds up digestion may be helpful. However, the benefits of fiber for IBS are uncertain, leading to a review of its use in managing this condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial.

Author: MadischA, HoltmannG, PleinK, HotzJ

Alleviate IBS symptoms

The commercially available herbal preparation STW 5 and its research preparation STW 5-II were effective in alleviating irritable bowel syndrome (IBS) symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

The effects of withdrawing tegaserod treatment in comparison with continuous treatment in irritable bowel syndrome patients with abdominal pain/discomfort, bloating and constipation: a clinical study.

Author: BardhanK D, ForbesA, MarsdenC L, MasonT, ShortG

Reduced symptom recurrence
Mild to moderate adverse events

Continuous or intermittent tegaserod treatment is less likely to result in symptom recurrence in patients with irritable bowel syndrome with constipation compared to withdrawal from treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome.

Author: QuarteroA O, Meineche-SchmidtV, MurisJ, RubinG, de WitN

Reduced IBS symptoms
Ineffectiveness

There is weak evidence for the efficacy of drug therapies for irritable bowel syndrome (IBS). Antispasmodic drugs may improve abdominal pain and global assessment of symptoms, but it is unclear whether anti-spasmodic subgroups are individually effective. There is no clear evidence of benefit for antidepressants or bulking agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation.

Author: TackJ, Müller-LissnerS, BytzerP, CorinaldesiR, ChangL, ViegasA, SchnekenbuehlS, Dunger-BaldaufC, RueeggP

Improved quality of life
Relief of IBS symptoms

Tegaserod provided rapid and sustained relief of irritable bowel syndrome with constipation symptoms both during first and repeated treatment. It also improved quality of life and was associated with greater satisfaction and work productivity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome--a double blind, placebo-controlled, randomized study.

Author: NivEva, NaftaliTimna, HallakRon, VaismanNachum

Placebo effect

IBS symptoms did not improve with probiotic treatment with L. reuteri.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

Herbal medicine with curcuma and fumitory in the treatment of irritable bowel syndrome: a randomized, placebo-controlled, double-blind clinical trial.

Author: BrinkhausBenno, HentschelChristian, Von KeudellChristoph, SchindlerGernot, LindnerMartin, StützerHartmut, KohnenRalf, WillichStefan N, LehmacherWalter, HahnEckhart G G

Ineffective treatment

This study found that neither fumitory nor curcuma showed any therapeutic benefit over placebo in patients with IBS.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

[Clinical observation on acupuncture combined with microorganism pharmaceutical preparations for treatment of irritable bowel syndrome of constipation type].

Author: LongZe-rong, YuCun-hai, YangYu, WangHuai-ning, ChiXiao-xia

Improved therapeutic effect on IBS

Acupuncture combined with microorganism pharmaceutical preparations showed better therapeutic effects for irritable bowel syndrome of constipation type than other treatment methods.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

39.

Systematic review: the efficacy of treatments for irritable bowel syndrome--a European perspective.

Author: TackJ, FriedM, HoughtonL A, SpicakJ, FisherG

Improvement in IBS symptoms
Well tolerated
Ischemic colitis
Severe constipation

There is limited evidence for the efficacy of currently available treatments for Irritable Bowel Syndrome (IBS) in Europe. New agents are needed to focus on and improve global IBS symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Where does hypnotherapy stand in the management of irritable bowel syndrome? A systematic review.

Author: GholamrezaeiAli, ArdestaniSamaneh Khanpour, EmamiMohammad Hasan

Improved IBS treatment
Irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common condition with no reliable medical treatment. While previous research suggests that hypnosis may be effective for IBS, more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Acupuncture for treatment of irritable bowel syndrome.

Author: LimB, ManheimerE, LaoL, ZieaE, WisniewskiJ, LiuJ, BermanB

Improved IBS treatment
Irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common condition characterized by abdominal pain, discomfort, and changes in bowel habits. IBS often leads to doctor visits and missed work, causing economic burdens. A recent study found mixed results for acupuncture as a treatment for IBS, with no clear evidence of its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Tegaserod for the treatment of irritable bowel syndrome and chronic constipation.

Author: EvansB W, ClarkW K, MooreD J, WhorwellP J

Improved IBS treatment
Irritable bowel syndrome

Irritable bowel syndrome (IBS) is a complex condition with a wide range of symptoms. Chronic constipation can often mimic IBS with constipation. Current medications for IBS are limited in their effectiveness, often only addressing specific symptoms. Tegaserod is a new medication that works differently, targeting IBS and chronic constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Hypnotherapy for treatment of irritable bowel syndrome.

Author: WebbA N, KukuruzovicR H, Catto-SmithA G, SawyerS M

Effective for IBS symptoms

This review found that the quality of the included trials was inadequate to allow any conclusion about the efficacy of hypnotherapy for irritable bowel syndrome. More research with high quality trials is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents.

Author: BaharRon J, CollinsBrynie S, SteinmetzBarry, AmentMarvin E

Improved quality of life
Reduced IBS symptoms

Amitriptyline (AMI) significantly improved overall quality of life in adolescents with irritable bowel syndrome (IBS). Patients taking AMI were more likely to experience improvement in their quality of life at 6, 10, and 13 weeks. They were also more likely to experience a reduction in IBS-associated diarrhea, periumbilical pain, and right lower quadrant pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome.

Author: MangelA W, BornsteinJ D, HammL R, BudaJ, WangJ, IrishW, UrsoD

Improved IBS pain
Improved IBS symptoms
Increased pain free days
Reduced pain scores

Asimaoline showed potential benefit for the treatment of irritable bowel syndrome (IBS).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Self-administered cognitive behavior therapy for moderate to severe irritable bowel syndrome: clinical efficacy, tolerability, feasibility.

Author: LacknerJeffrey M, JaccardJames, KrasnerSusan S, KatzLeonard A, GudleskiGregory D, HolroydKenneth

Improved IBS treatment
Irritable bowel syndrome

There is a need for new treatments for irritable bowel syndrome (IBS) that teach patients how to manage their symptoms and related problems, as existing medications have limitations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

48.

Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis.

Author: FordA C, TalleyN J, SchoenfeldP S, QuigleyE M M, MoayyediP

Improved IBS symptoms

Antidepressants are effective in treating irritable bowel syndrome (IBS), with a number needed to treat (NNT) of 4. While less high-quality evidence exists for psychological therapies, available data suggest comparable efficacy with an NNT of 4.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studies.

Author: DrossmanD A, CheyW D, JohansonJ F, FassR, ScottC, PanasR, UenoR

Improved IBS-C symptoms

Lubiprostone 8 mcg twice daily significantly improved the percentage of overall responders with irritable bowel syndrome with constipation (IBS-C) compared to placebo. Lubiprostone was well tolerated and had a favorable safety profile.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

[The use of bismuth tripotassium dicitrate (De-Nol), a promising line of pathogenetic therapy for irritated bowel syndrome with diarrhea].

Author: IakovenkoE P, AgafonovaN A, Pokhal'skaiaO Iu, KolganovaA V, NazarbekovaR S, IvanovA N, DavletshinaI V, PopovaE V, PrianishnikovaA S, OvchinnikovaN I, IakovenkoA V, AldiiarovaM A, D'iachkoavaA V, GioevaI Z

Improved IBS treatment
Irritable bowel syndrome

This study found that bismuth tripotassium dicitrate (De-nol) was effective for treating diarrhea-dominant irritable bowel syndrome (IBS) when used with a spasmolytic medication. After 3 weeks of treatment, 90% of the De-nol group and 60% of the control group had no abdominal pain. The De-nol group also saw improvements in bloating, diarrhea, and intestinal bacterial overgrowth. De-nol was found to be effective in resolving inflammation and restoring normal gut bacteria.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

51.

Psychological treatments for the management of irritable bowel syndrome.

Author: ZijdenbosIngeborg L, de WitNiek J, van der HeijdenGeert J, RubinGregory, QuarteroA Otto

Improved quality of life
Symptom improvement
Short-term effect

Psychological interventions may be slightly superior to usual care for irritable bowel syndrome (IBS), but their effects are not consistently superior to placebo, and long-term efficacy is questionable. More rigorous research is needed to clarify the effectiveness of these interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.

Author: HunLarysa

IBS symptom relief
Safe treatment

Preliminary data suggest that the patented B coagulans GBI-30, 6086 probiotic may be a safe and effective option for the relief of abdominal pain and bloating for patients with IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

[Tiaohe Ganpi Hexin Decoction in treatment of irritable bowel syndrome with diarrhea: a randomized controlled trial].

Author: LiangZhan-fan, ChenRi-hui, XuYun-sheng, ChenQing-xiang, DongMei-ling

Improved IBS symptoms

Tiaohe Ganpi Hexin Decoction (TGHD), a compound traditional Chinese herbal medicine for regulating the liver and spleen, significantly improved clinical symptoms in irritable bowel syndrome (IBS) patients with diarrhea. The total obviously effective rate was 85% in the TGHD group compared to 45% in the control group.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

54.

[Diagnosis of irritable bowel syndrome: a systematic review].

Author: ParkJung Ho, ByeonJeong-Sik, ShinWoon-Geon, YoonYoung Hun, CheonJae Hee, LeeKwang Jae, ParkJyojin,

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive disorder causing abdominal discomfort, bloating, and bowel problems. People with IBS see doctors more often, leading to significant costs. Guidelines for diagnosing and treating IBS aim to improve outcomes. Several sets of criteria are used to diagnose IBS, with Manning and Rome criteria being common. While specific tests for IBS are lacking, tests are often done to rule out other conditions. However, these tests are often not very accurate. This review aims to establish a strategy for treating IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Korean

55.

Rifaximin therapy for patients with irritable bowel syndrome without constipation.

Author: PimentelMark, LemboAnthony, CheyWilliam D, ZakkoSalam, RingelYehuda, YuJing, MareyaShadreck M, ShawAudrey L, BorteyEnoch, ForbesWilliam P,

Abdominal pain relief
Bloating relief
IBS symptom relief
Stool consistency improvement

Rifaximin was effective in treating irritable bowel syndrome (IBS) without constipation. In two phase 3 trials involving 166 patients, rifaximin treatment was associated with significant relief of IBS symptoms, bloating, abdominal pain, and loose stools compared to placebo.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome.

Author: RuepertLisa, QuarteroA Otto, de WitNiek J, van der HeijdenGeert J, RubinGregory, MurisJean Wm

IBS treatment

Bulking agents were not effective for treating irritable bowel syndrome (IBS). Antispasmodics, particularly cimetropium/dicyclomine, peppermint oil, pinaverium, and trimebutine, were effective. Antidepressants, particularly SSRIs and TCAs, were also effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Evaluation of harm in the pharmacotherapy of irritable bowel syndrome.

Author: ShahEric, KimSharon, ChongKelly, LemboAnthony, PimentelMark

Treatment of irritable bowel syndrome

This study examines the side effects of medications used to treat irritable bowel syndrome (IBS) with diarrhea and constipation. It looks at treatments recommended by the American College of Gastroenterology and uses a systematic review to assess the number of patients who experience harm from each medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Acupuncture for treatment of irritable bowel syndrome.

Author: ManheimerEric, ChengKe, WielandL Susan, MinLi Shih, ShenXueyong, BermanBrian M, LaoLixing

Treatment of IBS

Irritable bowel syndrome (IBS) is a common, costly, and difficult-to-treat condition that affects quality of life and productivity. While there are treatment guidelines, there is limited evidence on the effectiveness of acupuncture for IBS, as previous reviews included small, inconsistent, and poorly designed studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Mindfulness-based stress reduction for the treatment of irritable bowel syndrome symptoms: a randomized wait-list controlled trial.

Author: ZernickeKristin A, CampbellTavis S, BlusteinPhilip K, FungTak S, JohnsonJillian A, BaconSimon L, CarlsonLinda E

Reduced IBS
Reduced stress
Dropout rate

Mindfulness-based stress reduction (MBSR) was effective in reducing irritable bowel syndrome (IBS) symptom severity and stress in participants, maintaining these improvements at 6 months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis.

Author: Martínez-VázquezM A, Vázquez-ElizondoG, González-GonzálezJ A, Gutiérrez-UdaveR, Maldonado-GarzaH J, Bosques-PadillaF J

Improved IBS symptoms
No significant adverse effects

Antispasmodics were more effective than placebo in treating irritable bowel syndrome (IBS), with no significant adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study.

Author: TutejaAshok K, FangJohn C, Al-SuqiManal, StoddardGregory J, HaleDevon C

Treatment of PI-IBS

This study examines the effectiveness of mesalamine, an anti-inflammatory medication, in treating post-infective irritable bowel syndrome (PI-IBS). PI-IBS is a condition where IBS symptoms, usually diarrhea-predominant, persist after a stomach bug. The study compares mesalamine to a placebo in terms of improving symptoms and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

62.

Clinical trial: transcutaneous interferential electrical stimulation in individuals with irritable bowel syndrome - a prospective double-blind randomized study.

Author: CobanŞahin, AkbalErdem, KöklüSeyfettin, KöklüGülşah, UlaşlıMurat Alper, ErkeçSerap, AktaşBora, YükselOsman, KoçakErdem, ErdemHatice Rana

Improved GI function
Potential for IBS treatment
Treatment of IBS
Limited evidence for IBS
Needs further research
Potential for side effects

The cause of irritable bowel syndrome (IBS) is not fully understood, and there's no cure. Treatment focuses on managing symptoms. Some studies suggest that applying electrical stimulation to the skin (transcutaneous electrical stimulation) may be helpful for constipation, delayed stomach emptying, and indigestion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

63.

Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints.

Author: QuigleyE M M, TackJ, CheyW D, RaoS S, ForteaJ, FalquesM, DiazC, ShiffS J, CurrieM G, JohnstonJ M

Linaclotide improves IBS-C symptoms

Linaclotide significantly improved abdominal pain and discomfort and the degree-of-relief of irritable bowel syndrome with constipation symptoms compared with placebo over 12 and 26 weeks.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

64.

Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): study protocol for a randomised controlled trial.

Author: LeightonMatthew P, LamChing, MehtaSamir, SpillerRobin C

IBS treatment

This study aims to test the effectiveness of mesalazine, a medication used for inflammatory bowel disease, in treating diarrhea-predominant irritable bowel syndrome (IBS). The study will also investigate how mesalazine works, particularly its potential impact on mast cells, which are involved in inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

65.

[Probiotic supplement (Lactobacillus acidophilus and bulgaricus) utility in the treatment of irritable bowel syndrome].

Author: Diaz FerrerJavier, ParraVictor, BendañoTeofilo, MontesPedro, SolorzanoPaola

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive condition characterized by abdominal pain, bloating, and changes in bowel habits. Treatments focus on managing symptoms with medications like loperamide, antispasmodics, and antidepressants. Probiotics, live bacteria that may be beneficial for gut health, have recently been explored as a potential treatment.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

66.

Treatment of refractory irritable bowel syndrome with visceral osteopathy: short-term and long-term results of a randomized trial.

Author: AttaliThu-Van, BouchouchaMichel, BenamouzigRobert

Improved IBS symptoms

This randomized crossover placebo-controlled study evaluated the effectiveness of visceral osteopathy for irritable bowel syndrome (IBS). Visceral osteopathy significantly improved self-reported diarrhea, abdominal distension, and abdominal pain in IBS patients and also decreased rectal sensitivity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

67.

Randomised clinical trial: A liquid multi-strain probiotic vs. placebo in the irritable bowel syndrome--a 12 week double-blind study.

Author: SissonG, AyisS, SherwoodR A, BjarnasonI

IBS treatment

The relationship between the gut bacteria and the body is increasingly recognized as important in irritable bowel syndrome (IBS). Probiotics, which are live bacteria that may be beneficial for gut health, are a potential new treatment for IBS. However, research results are inconsistent, likely due to poorly designed studies and a lack of standardized ways to measure outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis.

Author: FordAlexander C, QuigleyEamonn M M, LacyBrian E, LemboAnthony J, SaitoYuri A, SchillerLawrence R, SofferEdy E, SpiegelBrennan M R, MoayyediPaul

Effective IBS treatment

Antidepressants and some psychological therapies are effective treatments for irritable bowel syndrome (IBS). The overall summary estimates of treatment effect have remained remarkably stable in the intervening 5 years since the last meta-analysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

A mixed methods feasibility study to evaluate the use of a low-intensity, nurse-delivered cognitive behavioural therapy for the treatment of irritable bowel syndrome.

Author: DaintyAndrew David, FoxMark, LewisNina, HuntMelissa, HolthamElizabeth, TimmonsStephen, KinsellaPhilip, WraggAndrew, CallaghanPatrick

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive condition that can cause pain, constipation, diarrhea, and bloating. IBS affects quality of life, increases healthcare costs, and puts a strain on healthcare systems. While cognitive behavioral therapy (CBT) is a proven treatment for IBS, access to CBT in the UK healthcare system remains challenging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

70.

Therapeutic effects, tolerability and safety of a multi-strain probiotic in Iranian adults with irritable bowel syndrome and bloating.

Author: JafariElham, VahediHomayoon, MeratShahin, MomtahenShabnam, RiahiAina

Probiotics efficacy
Symptom relief

A 4-week period of treatment with a combination of probiotics twice daily was safe, well tolerated, and effective in Iranian adults with irritable bowel syndrome (IBS) with abdominal bloating. The probiotic group reported satisfactory relief of general symptoms in 85% of patients compared with 47% in the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

71.

Low-FODMAP Diet for Irritable Bowel Syndrome: Is It Ready for Prime Time?

Author: KhanMuhammad Ali, NusratSalman, KhanMuhammad Imran, NawrasAli, BielefeldtKlaus

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive disorder that significantly affects quality of life. While the exact cause of IBS isn't fully understood, treatments often don't effectively manage symptoms. One promising approach is a diet that restricts certain carbohydrates called FODMAPs, which are not fully absorbed and can cause digestive problems. Studies show this diet can reduce IBS symptoms. However, it can also alter the beneficial bacteria in the gut, which needs further study.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

72.

Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis.

Author: TiequnBian, GuanqunChao, ShuoZhang

Clinical improvement
None reported

This meta-analysis systematically evaluated the effect of Lactobacillus in treating irritable bowel syndrome (IBS). Six randomized, placebo-controlled trials showed a significantly higher rate of treatment responders with Lactobacillus compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

73.

Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis.

Author: MarshAbigail, EslickEnid M, EslickGuy D

IBS and IBD treatment

Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are characterized by digestive symptoms like pain, bloating, constipation, and diarrhea. Finding an effective treatment has been difficult, as most treatments only address a single symptom. A new dietary approach called the low FODMAP diet has shown promise. This study examines the evidence for the effectiveness of this diet in treating IBS and IBD symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

[A meta-analysis of probiotics for the treatment of irritable bowel syndrome].

Author: HuYue, TaoLiyuan, LyuBin

Improved IBS symptoms

Probiotics have beneficial effects on irritable bowel syndrome (IBS), improving symptoms with less adverse reaction. However, further large-scale, multicenter, and high-quality randomized controlled trials are needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Chinese

75.

Assessing Cognitive behavioural Therapy in Irritable Bowel (ACTIB): protocol for a randomised controlled trial of clinical-effectiveness and cost-effectiveness of therapist delivered cognitive behavioural therapy and web-based self-management in irritable bowel syndrome in adults.

Author: EverittHazel, LandauSabine, LittlePaul, BishopFelicity L, McCronePaul, O'ReillyGilly, ColemanNicholas, LoganRobert, ChalderTrudie, Moss-MorrisRona,

IBS treatment

Irritable bowel syndrome (IBS) affects a significant portion of the UK population and is costly to manage. IBS causes abdominal pain, bloating, and changes in bowel habits, impacting quality of life and work. While treatments focus on diagnosis, reassurance, lifestyle advice, and medication, many people continue to experience symptoms. Cognitive behavioral therapy (CBT) and self-management techniques can be helpful, but access to these options is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

76.

Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial.

Author: ShulmanRobert J, HollisterEmily B, CainKevin, CzyzewskiDanita I, SelfMariella M, WeidlerErica M, DevarajSridevi, LunaRuth Ann, VersalovicJames, HeitkemperMargaret

IBS treatment

Psyllium fiber treatment was effective in reducing abdominal pain and improving stool patterns in children with IBS. The treatment led to a significant decrease in breath hydrogen and methane production, suggesting improved gut function. While psyllium fiber did not significantly alter gut permeability, it did lead to changes in the gut microbiome composition. Interestingly, the response to treatment was not influenced by the psychological characteristics of the children or their parents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

77.

Home-Based Hypnotherapy Self-exercises vs Individual Hypnotherapy With a Therapist for Treatment of Pediatric Irritable Bowel Syndrome, Functional Abdominal Pain, or Functional Abdominal Pain Syndrome: A Randomized Clinical Trial.

Author: RuttenJuliette M T M, VliegerArine M, FrankenhuisCarla, GeorgeElvira K, GroenewegMichael, NorbruisObbe F, Tjon A TenWalther, van WeringHerbert M, DijkgraafMarcel G W, MerkusMaruschka P, BenningaMarc A

Effective IBS treatment
Improved quality of life

This study compared the effectiveness of home-based hypnotherapy (HT) with a CD to individual HT performed by therapists in children with irritable bowel syndrome (IBS) or functional abdominal pain. The study found that home-based HT with a CD was noninferior to individual HT in terms of long-term effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

78.

The journey between brain and gut: A systematic review of psychological mechanisms of treatment effect in irritable bowel syndrome.

Author: WindgassenSula, Moss-MorrisRona, ChilcotJoseph, SibelliAlice, GoldsmithKimberley, ChalderTrudie

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive condition that affects 10-22% of people in the UK. While psychological interventions are increasingly used to treat IBS, there is limited understanding of how these treatments work. This review aims to investigate the mechanisms of psychological interventions for IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Assessment of the effectiveness and safety of ethosuximide in the treatment of abdominal pain related to irritable bowel syndrome - IBSET: protocol of a randomised, parallel, controlled, double-blind and multicentre trial.

Author: KerckhoveNicolas, ScanziJulien, PereiraBruno, ArdidDenis, DapoignyMichel

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive disorder causing chronic abdominal pain and bowel problems. While IBS isn't life-threatening, it significantly affects quality of life and is costly to manage. Current treatments are not very effective, and the exact causes of IBS are unknown. Recent research suggests that a type of channel in the nervous system, called a T-type channel, may play a role in IBS pain. This study aims to investigate whether ethosuximide, a medication that blocks T-type channels, can help relieve abdominal pain in people with IBS.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

80.

Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial.

Author: ZahediMohammad Javad, BehrouzVahideh, AzimiMaryam

IBS-D treatment

A new diet called a low FODMAP diet has shown promise in treating irritable bowel syndrome (IBS). This study compared the low FODMAP diet to general dietary advice for people with IBS-D (IBS with diarrhea) to see which approach worked better.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

82.

The Role of Diet in the Treatment of Irritable Bowel Syndrome: A Systematic Review.

Author: SinghRajdeep, SalemAhmed, NanavatiJulie, MullinGerard E

Dietary intervention
IBS treatment
FODMAPs controversy

Irritable bowel syndrome (IBS) is a complex condition affecting the digestive system and is influenced by a variety of factors, including diet. While many diets have shown promise in easing IBS symptoms, the low-FODMAP diet, which restricts certain types of sugars, is particularly controversial. This review examines the role of diet in IBS and specifically analyzes the evidence for the low-FODMAP diet.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Exercise therapy of patients with irritable bowel syndrome: A systematic review of randomized controlled trials.

Author: ZhouChangli, ZhaoEnfa, LiYuewei, JiaYong, LiFeng

Exercise
IBS treatment

While medications have limitations in treating irritable bowel syndrome (IBS), non-drug therapies and exercise are becoming more important. It's known that exercise can affect bowel function, but its impact on IBS symptoms is not fully understood. This study aims to investigate the effects of exercise on IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review.

Author: PittayanonRapat, LauJennifer T, YuanYuhong, LeontiadisGrigorios I, TseFrances, SuretteMichael, MoayyediPaul

Gut microbiota
IBS treatment

Irritable bowel syndrome (IBS) is a common and challenging condition to treat. Altering the bacteria in the gut (microbiota) has been proposed as a potential treatment, but the link between the gut microbiome and IBS symptoms needs further research. This review examines the evidence for this connection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT.

Author: EverittHazel, LandauSabine, LittlePaul, BishopFelicity L, O'ReillyGillian, SibelliAlice, HollandRachel, HughesStephanie, WindgassenSula, McCronePaul, GoldsmithKim, ColemanNicholas, LoganRobert, ChalderTrudie, Moss-MorrisRona

CBT
IBS treatment

Irritable bowel syndrome (IBS) is common and can affect people's lives. While treatment focuses on diagnosis, reassurance, lifestyle changes, and medications, many people continue to experience symptoms. Cognitive-behavioral therapy (CBT) is recommended for ongoing IBS, but access to CBT is limited.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

86.

Abnormalities of mucosal serotonin metabolism and 5-HT<sub>3</sub> receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron.

Author: GunnDavid, GarsedKlara, LamChing, SinghGulzar, LingayaMelanie, WahlVerena, NieslerBeate, HenryAmanda, HallIan P, WhorwellPeter, SpillerRobin

Improved IBS-D symptoms

Patients with irritable bowel syndrome with diarrhoea (IBS-D) have significant abnormalities in mucosal 5-HT metabolism. Ondansetron, a 5-HT receptor 3 antagonist, was effective in treating IBS-D, with those having the lowest concentration of 5-HT in rectal biopsies showing the greatest responsiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

87.

Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study.

Author: BrennerDarren M, SayukGregory S, GutmanCatherine R, JoEsther, ElmesSteven J R, LiuLouis W C, CashBrooks D

IBS-D symptom improvement
Safe and effective

Eluxadoline was effective and safe in treating irritable bowel syndrome with diarrhea (IBS-D) symptoms in patients with an intact gallbladder reporting inadequate relief with prior loperamide use.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

89.

Vortioxetine effects on quality of life of irritable bowel syndrome patients: A randomized, double-blind, placebo-controlled trial.

Author: SeddighniaAzadeh, Tadayon NajafabadiBorna, GhamariKiandokht, NoorbalaAhmad Ali, Ebrahimi DaryaniNaser, KashaniLadan, AkhondzadehShahin

Improved quality of life
Reduced IBS symptoms

Vortioxetine was superior to placebo in increasing quality of life in patients with irritable bowel syndrome (IBS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

90.

Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.

Author: HawrelakJason A, WohlmuthHans, PattinsonMartina, MyersStephen P, GoldenbergJoshua Z, HarnettJoanna, CooleyKieran, Van De VenterClaudine, ReidRebecca, WhittenDawn L

Aloe vera efficacy
Asafoetida efficacy
IBS symptom relief
Peppermint oil efficacy
Lack of replication
Limited efficacy evidence

The review of 33 trials evaluating Western herbal medicines for irritable bowel syndrome (IBS) suggests that several may provide relief from symptoms. Peppermint essential oil was found to be both effective and well-tolerated in the short-term management of IBS. Aloe vera and asafoetida also demonstrated efficacy in reducing global IBS symptoms. However, replication of the positive findings for most other herbal medicines is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Clinical efficacy and safety of ketotifen in treating irritable bowel syndrome with diarrhea.

Author: WangJing, WangYucheng, ZhouHaibin, GuWeigang, WangXia, YangJianfeng

Improved visceral hypersensitivity
Reduced IBS symptoms
Drowsiness
Fatigue

Ketotifen effectively alleviated gastrointestinal symptoms and improved visceral hypersensitivity in patients with irritable bowel syndrome with diarrhea (IBS-D), likely through reducing mast cell number and activity in the intestinal mucosa.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

92.

Hypnotherapy for Irritable Bowel Syndrome-Type Symptoms in Patients with Quiescent Inflammatory Bowel Disease: A Randomized, Controlled Trial.

Author: HoekmanDaniël R, VliegerArine M, StokkersPieter C, MahhmodNofel, RietdijkSvend, de BoerNanne K, de MeijTim G, FrankenhuisCarla, D'HaensGeert R, BenningaMarc A

IBS-type symptoms

This study compared the effectiveness of gut-directed hypnotherapy and standard medical treatment (SMT) for irritable bowel syndrome (IBS)-type symptoms in inflammatory bowel disease (IBD) patients in remission. The study found that hypnotherapy was not superior to SMT in the treatment of IBS-type symptoms in IBD patients. Both treatment strategies are reasonable options from a clinical perspective.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

93.

A Novel Mobile App (Heali) for Disease Treatment in Participants With Irritable Bowel Syndrome: Randomized Controlled Pilot Trial.

Author: RaffertyAaron J, HallRick, JohnstonCarol S

IBS treatment

A low FODMAP diet has been shown to help people with irritable bowel syndrome (IBS). However, sticking to this diet can be difficult because information provided by doctors is often general, making people search for more specific advice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

94.

INTERVENTIONS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME: A REVIEW OF COCHRANE SYSTEMATIC REVIEWS.

Author: ScaciotaAna Carolina Lemes, MatosDelcio, RosaManuelle Mastrorocco Brand, ColovatiMileny Esbravatti Stephano, BellottoElisa Fatima Benavent Caldas, MartimbiancoAna Luiza Cabrera

IBS symptom improvement

Pharmacological treatment with antispasmodics and antidepressants seems to be beneficial for patients with irritable bowel syndrome. Psychological interventions also seem to be beneficial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

Systematic review and network meta-analysis: efficacy of licensed drugs for abdominal bloating in irritable bowel syndrome with constipation.

Author: NelsonAlfred D, BlackChristopher J, HoughtonLesley A, Lugo-FagundoNahyr Sofía, LacyBrian E, FordAlexander C

Improved bloating
Superior to placebo

Linaclotide, lubiprostone, tenapanor, and tegaserod were all found to be superior to placebo in relieving abdominal bloating in patients with IBS-C. Linaclotide was the most effective, with a relative risk of failure to improve bloating of 0.78 (95% CI 0.74-0.83) and a number needed to treat of 7.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Current status of fecal microbiota transplantation for irritable bowel syndrome.

Author: El-SalhyMagdy, HauskenTrygve, HatlebakkJan Gunnar

FMT for IBS
FMT adverse effects

Fecal microbiota transplantation (FMT) shows promise for treating irritable bowel syndrome (IBS), but its efficacy is donor-dependent. A review of 7 RCTs found that FMT was effective in some studies but not others. The selection of donors with favorable microbiota signatures and further research on optimal dosing and routes of administration are crucial for improving FMT outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Long-Term Effects of a Web-Based Low-FODMAP Diet Versus Probiotic Treatment for Irritable Bowel Syndrome, Including Shotgun Analyses of Microbiota: Randomized, Double-Crossover Clinical Trial.

Author: AnkersenDorit Vedel, WeimersPetra, BennedsenMette, HaaberAnne Birgitte, FjordsideEva Lund, BeberMoritz Emanuel, LievenChristian, SabooriSanaz, VadNicolai, RannemTerje, MarkerDorte, ParidaensKristine, FrahmSuzanne, JensenLisbeth, Rosager HansenMalte, BurischJohan, MunkholmPia

IBS management
eHealth interventions

This study explores the use of online tools (eHealth interventions) to help manage irritable bowel syndrome (IBS) in the long term. While previous research shows that these tools can be helpful in monitoring the effects of probiotics and low-FODMAP diets, the study highlights the need for further research to understand the long-term impact of these interventions. The study also emphasizes the role of gut bacteria (microbiota) in IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

99.

A systematic review and meta-analysis on the prevalence of non-malignant, organic gastrointestinal disorders misdiagnosed as irritable bowel syndrome.

Author: PoonDennis, LawGraham R, MajorGiles, AndreyevH Jervoise N

IBS treatment

This study found that a significant number of people diagnosed with irritable bowel syndrome (IBS) in a hospital setting actually have other treatable digestive conditions. The study found high rates of conditions like bile acid diarrhea (41%), microscopic colitis (3%), and small intestinal bacterial overgrowth (SIBO) in people with IBS. This highlights the importance of ruling out these conditions to provide effective treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Efficacy and safety of a food supplement with standardized menthol, limonene, and gingerol content in patients with irritable bowel syndrome: A double-blind, randomized, placebo-controlled trial.

Author: IvashkinVladimir T, KudryavtsevaAnna V, KrasnovGeorge S, PoluektovYuri M, MorozovaMargarita A, ShifrinOleg S, BeniashviliAllan G, MamievaZarina A, KovalevaAlexandra L, UlyaninAnatoly I, TrushElizaveta A, ErlykinAlexander G, PoluektovaElena A

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive disorder that places a burden on healthcare systems. While many medications are used for IBS, including antispasmodics, laxatives, and anti-diarrheal medications, they often don't work well. We need new and effective treatments for IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

101.

[The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel syndrome. Prospective randomized comparative study].

Author: YakovenkoE P, StrokovaT V, IvanovA N, IakovenkoA V, GioevaI Z, AldiyarovaM A

Improved microbiota
Reduced inflammation
None

Bifiform, a probiotic supplement, significantly increased the effectiveness of treatment for post-infectious irritable bowel syndrome (PI-IBS). Bifiform helped arrest clinical manifestations of the disease, restore the normal composition of the intestinal microbiome, and reduce the inflammatory process in the intestinal mucosa.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

102.

Rifaximin Treatment for Individual and Multiple Symptoms of Irritable Bowel Syndrome With Diarrhea: An Analysis Using New End Points.

Author: LacyBrian E, ChangLin, RaoSatish S C, HeimansonZeev, SayukGregory S

Improved IBS-D symptoms

This post hoc analysis of three clinical trials evaluated the efficacy of rifaximin on individual and composite irritable bowel syndrome with diarrhea (IBS-D) symptoms. Rifaximin significantly improved multiple concurrent IBS-D symptoms, including abdominal pain, bloating, and urgency. Using a novel tri-symptom composite end point, rifaximin demonstrated significantly greater response rates compared to placebo. These findings highlight the potential for rifaximin to provide robust clinical improvements in IBS-D patients.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

103.

Efficacy and safety of probiotics in the treatment of irritable bowel syndrome: A systematic review and meta-analysis of randomised clinical trials using ROME IV criteria.

Author: KonstantisGeorgios, EfstathiouStylianos, PourzitakiChryssa, KitsikidouElisavet, GermanidisGeorgios, ChourdakisMichail

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive disorder. While studies suggest that probiotics may help manage IBS, the results are mixed. This study aims to investigate the effectiveness of probiotics in treating IBS, specifically focusing on which types of probiotic strains are most beneficial.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

104.

Fecal microbiota transplantation for the treatment of irritable bowel syndrome: A systematic review and meta-analysis.

Author: HalkjærSofie Ingdam, LoBobby, ColdFrederik, Højer ChristensenAlice, HolsterSavanne, KönigJulia, BrummerRobert Jan, AroniadisOlga C, LahtinenPerttu, HolvoetTom, GluudLise Lotte, PetersenAndreas Munk

IBS treatment

Irritable bowel syndrome (IBS) is a common digestive disorder that affects people's lives, work, and healthcare costs. Research shows that people with IBS have different bacteria in their gut (gut dysbiosis). Transferring healthy gut bacteria from one person to another (fecal microbiota transplantation or FMT) is being explored as a potential treatment for IBS.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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