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Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial.

Author: AcklNibal, HatzingerMartin, HeldKatja, HolsboerFlorian, Holsboer-TrachslerEdith, IsingMarcus, KaschkaWolfgang, KasperSiegfried, KonstantinidisAnastasios, KünzelHeike E, SonntagAnnette, SteigerAxel, UhrManfred, YassouridisAlexander

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Delusional depression is a challenging condition to treat. Trimipramine, an atypical antidepressant, has demonstrated effectiveness in previous studies. The key mechanism of trimipramine is inhibition of the HPA system, which is thought to be overactive in delusional depression.
Paper Details　
Original Abstract of the Article :
Patients with delusional depression are difficult to treat. The atypical antidepressant trimipramine was effective in a previous 4-week open label pilot study in patients with this disorder. The major neurobiological effect of trimipramine is the inhibition of the hypothalamic-pituitary-adrenocortic...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpsychires.2008.10.004

データ提供：米国国立医学図書館（NLM）

Delusional Depression: Seeking a Stable Oasis in the Desert of Mental Illness

The treatment of [delusional depression], a severe and challenging subtype of depression, presents significant challenges in the field of [psychiatry]. This study explores the efficacy of two different treatment approaches for this disorder: [trimipramine monotherapy] and a [combination therapy] of [amitriptyline] and [haloperidol]. The researchers conducted a double-blind, multicenter trial to compare the effectiveness of these treatments.

Unveiling the Therapeutic Landscape: A Tale of Two Treatments

The study found that trimipramine monotherapy was more effective in reducing [delusional symptoms] and improving overall clinical outcomes compared to the combination therapy. This finding suggests that trimipramine, which is known to [inhibit the hypothalamic-pituitary-adrenocortical (HPA) system], might be a more effective treatment for delusional depression. This is like finding a well-established desert oasis, offering a stable and effective refuge from the harsh realities of mental illness.

Exploring the HPA Axis: A Key to Understanding Delusional Depression

The study's findings highlight the potential role of [HPA overactivity] in the development of delusional depression. The researchers suggest that trimipramine's effectiveness in treating this disorder might be related to its ability to [suppress HPA activity]. This insight underscores the importance of understanding the neurobiological mechanisms underlying mental illness and developing treatments that target specific pathways. This is like understanding the intricate dynamics of a desert ecosystem – recognizing the key factors that contribute to its stability and resilience.

Dr.Camel's Conclusion

This study provides valuable insights into the treatment of delusional depression, highlighting the potential benefits of trimipramine monotherapy. The findings underscore the importance of understanding the neurobiological mechanisms underlying mental illness and developing targeted treatments that address specific pathways.

Date :
  1. Date Completed 2009-07-15
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

19038406

DOI: Digital Object Identifier

10.1016/j.jpsychires.2008.10.004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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