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Combined effects of terazosin and genistein on a metastatic, hormone-independent human prostate cancer cell line.

Author: ChangKee-Lung, ChengHsiao-Ling, ChihTsai-Tung, HsiehBau-Shan, HuYu-Chen, HuangLi-Wen, ShyuHuey-Wen, SuShu-Jem

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the therapeutic potential of combining terazosin and genistein, two drugs with anticancer properties, for treating metastatic, androgen-independent prostate cancer. The combination was more effective in inhibiting cell growth and VEGF expression and inducing apoptosis than either drug alone.
Paper Details　
Original Abstract of the Article :
Metastatic prostate cancer progresses from androgen-dependent to androgen-independent. Terazosin, a long-acting selective alpha1-adrenoreceptor antagonist, induces apoptosis of prostate cancer cells in an alpha1-adrenoreceptor-independent manner, while genistein, a major soy isoflavone, inhibits the...See full text at original site
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引用元：
https://doi.org/10.1016/j.canlet.2008.10.033

データ提供：米国国立医学図書館（NLM）

Combating Prostate Cancer: A Synergistic Approach

Prostate cancer, a common and often aggressive disease, requires a multi-pronged approach to effectively manage and treat. This study explores the potential of combining two promising agents, terazosin and genistein, to combat metastatic, hormone-independent prostate cancer.

A Powerful Combination for Prostate Cancer Treatment

The research demonstrates the synergistic effect of combining terazosin and genistein in inhibiting the growth of prostate cancer cells, particularly the aggressive DU-145 cell line. This combination was more effective in inducing apoptosis (programmed cell death) and reducing the expression of VEGF, a protein that promotes tumor growth, than either agent alone.

Hope for a More Effective Prostate Cancer Treatment

This study suggests that combining terazosin and genistein may offer a more potent and effective strategy for treating metastatic, hormone-independent prostate cancer. This approach could potentially improve treatment outcomes and enhance the quality of life for patients battling this challenging disease.

Dr. Camel's Conclusion

Just like a camel navigating a treacherous desert, finding effective treatments for prostate cancer requires a strategic approach. This research showcases the potential of combining terazosin and genistein, offering a promising avenue for overcoming the challenges associated with this disease.
Date :
  1. Date Completed 2009-03-18
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19091461

DOI: Digital Object Identifier

10.1016/j.canlet.2008.10.033

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in preparation
Languages

English

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